Volume 555 Number 7696

Editorials

AI diagnostics need attention p.285

Computer algorithms to detect disease show great promise, but they must be developed and applied with care.

doi: 10.1038/d41586-018-03067-x

News

News Features

News & Views

Oxidation softens mantle rocks p.314

Seismic waves that propagate through a layer of Earth’s upper mantle are highly attenuated. Contrary to general thinking, this attenuation seems to be strongly affected by oxidation conditions, rather than by water content.

doi: 10.1038/d41586-018-02828-y

Questioning human neurogenesis p.315

Neurons are born in the brain’s hippocampus throughout adulthood in mammals, contributing to the region’s functions in memory and mood. But a study now questions whether this phenomenon really extends to humans.

doi: 10.1038/d41586-018-02629-3

Landscapes of childhood tumours p.316

Two analyses of the genetic alterations that characterize paediatric cancers reveal key differences from adult cancers, and point to ways of optimizing therapeutic approaches to combating cancer in children.

doi: 10.1038/d41586-018-01648-4

Waves cornered p.318

The experimental discovery of materials known as higher-order topological insulators corroborates theoretical predictions and expands the toolbox for integrated optics and mechanical devices.

doi: 10.1038/d41586-018-02868-4

Melanin triggers antifungal defences p.319

Melanins are enigmatic pigments that have many roles, and the melanin in pathogenic fungi can aid host infection. Identification of a mammalian protein that recognizes melanin now reveals an antifungal defence pathway.

doi: 10.1038/d41586-018-02370-x

Articles

Letters

Altruism in a volatile world p.359

A derivation of Hamilton’s rule that considers explicit environmental stochasticity can predict when organisms should pay a cost to influence the variance in the reproductive success of their relatives, formalizing the link between bet-hedging and altruism.

doi: 10.1038/nature25965