네이처 컨텐츠

Editorials

The serendipity test p.5

Scientists often herald the role of chance in research. A project in Britain aims to test the popular idea with evidence.

doi: 10.1038/d41586-018-01405-7

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News

News Features

News & Views

Regeneration writ large p.34

The assembly of genome sequences for the flatworm Schmidtea mediterranea and the salamander Ambystoma mexicanum will provide insights into the remarkable regenerative characteristics of these two organisms.

doi: 10.1038/d41586-017-09008-4

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A rude awakening from tumour cells p.35

In women who have had breast cancer, drug treatments are often stopped five years after removal of the primary tumour. A meta-analysis shows that these individuals are still at risk of relapse.

doi: 10.1038/d41586-018-01140-z

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Reactive carbon species tamed for synthesis p.36

A highly reactive form of carbon, known as a carbyne, holds great promise for organic synthesis, but has been difficult to prepare. Reactions that produce carbyne equivalents now unleash this synthetic potential.

doi: 10.1038/d41586-018-01308-7

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A non-tailed twist in the viral tale p.38

Microscopy studies indicate that the most common viruses in the sea lack a tail structure. However, most cultured marine viruses have tails. A family of these elusive non-tailed marine viruses has now been identified.

doi: 10.1038/d41586-018-00923-8

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Pollen weighs in on a climate conundrum p.39

Simulations by climate models show that Earth warmed during the Holocene epoch, whereas ocean sedimentary cores suggest that global cooling occurred. An analysis of fossil pollen samples now sides with the models.

doi: 10.1038/d41586-018-00943-4

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Review

Articles

The axolotl genome and the evolution of key tissue formation regulators OPEN p.50

Sequencing and assembly of the 32-Gb genome of the Mexican axolotl reveals that it lacks the developmental gene Pax3, which is essential in other vertebrates; the genome sequence could improve our understanding of the evolution of the axolotl’s remarkable regenerative capabilities.

Sergej Nowoshilow, Siegfried Schloissnig, Ji-Feng Fei, Andreas Dahl, Andy W. C. Pang, Martin Pippel, Sylke Winkler, Alex R. Hastie, George Young, Juliana G. Roscito + et al.

doi: 10.1038/nature25458

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The genome of Schmidtea mediterranea and the evolution of core cellular mechanisms OPEN p.56

An improved genome assembly for Schmidtea mediterranea shows that the genome is highly polymorphic and repetitive, and lacks multiple genes encoding core components of cell biological mechanisms.

Markus Alexander Grohme, Siegfried Schloissnig, Andrei Rozanski, Martin Pippel, George Robert Young, Sylke Winkler, Holger Brandl, Ian Henry, Andreas Dahl, Sean Powell + et al.

doi: 10.1038/nature25473

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Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes p.62

Oncogenic dosage variation along distinct evolutionary routes defines fundamental aspects of pancreatic cancer biology and phenotypic diversification.

Sebastian Mueller, Thomas Engleitner, Roman Maresch, Magdalena Zukowska, Sebastian Lange, Thorsten Kaltenbacher, Björn Konukiewitz, Rupert Öllinger, Maximilian Zwiebel, Alex Strong + et al.

doi: 10.1038/nature25459

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Letters

Generating carbyne equivalents with photoredox catalysis p.86

A photocatalytic strategy is described that generates diazomethyl radicals as direct equivalents of carbynes, which are often too reactive to use, enabling the functionalization of a range of medically useful compounds.

Zhaofeng Wang, Ana G. Herraiz, Ana M. del Hoyo & Marcos G. Suero

doi: 10.1038/nature25185

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Hierarchically related lineage-restricted fates of multipotent haematopoietic stem cells p.106

Analysis of transplantation of single haematopoietic stem cells in mice defines stable lineage-restricted fates in long-term self-renewing multipotent stem cells, including a class of multipotent stem cells that exclusively replenishes the megakaryocyte/platelet lineage.

Joana Carrelha, Yiran Meng, Laura M. Kettyle, Tiago C. Luis, Ruggiero Norfo, Verónica Alcolea, Hanane Boukarabila, Francesca Grasso, Adriana Gambardella, Amit Grover + et al.

doi: 10.1038/nature25455

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Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders p.112

Mutations associated with Treacher Collins syndrome perturb the subnuclear localization of an RNA helicase involved in ribosome biogenesis through activation of p53 protein, illustrating how disruption in general regulators that compromise nucleolar homeostasis can result in tissue-selective malformations.

Eliezer Calo, Bo Gu, Margot E. Bowen, Fardin Aryan, Antoine Zalc, Jialiang Liang, Ryan A. Flynn, Tomek Swigut, Howard Y. Chang, Laura D. Attardi + et al.

doi: 10.1038/nature25449

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A major lineage of non-tailed dsDNA viruses as unrecognized killers of marine bacteria p.118

Members of a family of marine dsDNA non-tailed bacterial viruses have short, 10-kb genomes, infect a broader range of hosts than tailed viruses and belong to the double jelly roll capsid lineage of viruses, which are associated with diverse bacterial and archaeal hosts.

Kathryn M. Kauffman, Fatima A. Hussain, Joy Yang, Philip Arevalo, Julia M. Brown, William K. Chang, David VanInsberghe, Joseph Elsherbini, Radhey S. Sharma, Michael B. Cutler + et al.

doi: 10.1038/nature25474

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Tet2 promotes pathogen infection-induced myelopoiesis through mRNA oxidation p.123

A report of RNA 5-methylcytosine oxidation by mammalian Tet2, showing that Tet2 promotes infection-induced myelopoiesis in mice via a mechanism involving the repression of Socs3 mRNA, a previously unknown regulatory role of Tet2 at the epitranscriptomic level.

Qicong Shen, Qian Zhang, Yang Shi, Qingzhu Shi, Yanyan Jiang, Yan Gu, Zhiqing Li, Xia Li, Kai Zhao, Chunmei Wang + et al.

doi: 10.1038/nature25434

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Mitochondrial translation requires folate-dependent tRNA methylation p.128

Mammalian mitochondria use folate-bound one-carbon units generated by the enzyme SHMT2 to methylate tRNA, and this modification is required for mitochondrial translation and thus oxidative phosphorylation.

Raphael J. Morscher, Gregory S. Ducker, Sophia Hsin-Jung Li, Johannes A. Mayer, Zemer Gitai, Wolfgang Sperl & Joshua D. Rabinowitz

doi: 10.1038/nature25460

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