네이처 컨텐츠

Editorials

News

News Features

How to see a memory p.146

Every memory leaves its own imprint in the brain, and researchers are starting to work out what one looks like.

doi: 10.1038/d41586-018-00107-4

전문

News & Views

Cometary spin-down p.158

The rotation rate of a comet more than halved in two months — a much greater change than has previously been observed. This suggests that the comet is in a distinct evolutionary state and might soon reorient itself.

doi: 10.1038/d41586-018-00008-6

전문

Neuronal plasticity in nematode worms p.159

Neuronal activity induces changes in the connectivity of a neuron called DVB in adult male nematode worms. This discovery provides an opportunity to study a fundamental process in this powerful model organism.

doi: 10.1038/d41586-017-09031-5

전문

Dogma-breaking catalysis p.160

The catalysts conventionally used for industrially important hydrogenation reactions are expensive and generate toxic residues. Catalysts have now been reported that might lead to cheaper, less toxic alternatives.

doi: 10.1038/d41586-017-09006-6

전문

An ode to gene edits that prevent deafness p.162

Gene editing can prevent inherited deafness in mice by disabling a mutant version of a gene that causes hearing loss. Is this a turning point on the path towards treating some types of human deafness?

doi: 10.1038/d41586-017-08645-z

전문

Rule-breaking perovskites p.163

A material from the perovskite family of semiconductors emits light much more efficiently than expected. The explanation for this anomalous behaviour could lead to improvements in light-emitting technology.

doi: 10.1038/d41586-018-00012-w

전문

Articles

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells p.171

Endogenous and alcohol-derived acetaldehyde causes a specific pattern of DNA damage in haemopoietic stem cells; the effects are mitigated by detoxification, specific DNA repair mechanisms and a p53 response.

Juan I. Garaycoechea, Gerry P. Crossan, Frédéric Langevin, Lee Mulderrig, Sandra Louzada, Fentang Yang, Guillaume Guilbaud, Naomi Park, Sophie Roerink, Serena Nik-Zainal + et al.

doi: 10.1038/nature25154

전문 |PDF

Letters

Rotation in [C ii]-emitting gas in two galaxies at a redshift of 6.8 p.178

The earliest galaxies are thought to have emerged during the first billion years of cosmic history, initiating the ionization of the neutral hydrogen that pervaded the Universe at this time. Studying this ‘epoch of reionization’ involves looking for the spectral signatures of ancient galaxies that are, owing to the expansion of the Universe, now very distant from Earth and therefore exhibit large redshifts. However, finding these spectral fingerprints is challenging. One spectral characteristic of ancient and distant galaxies is strong hydrogen-emission lines (known as Lyman-α lines), but the neutral intergalactic medium that was present early in the epoch of reionization scatters such Lyman-α photons. Another potential spectral identifier is the line at wavelength 157.4 micrometres of the singly ionized state of carbon (the [C ii] λ = 157.74 μm line), which signifies cooling gas and is expected to have been bright in the early Universe. However, so far Lyman-α-emitting galaxies from the epoch of reionization have demonstrated much fainter [C ii] luminosities than would be expected from local scaling relations, and searches for the [C ii] line in sources without Lyman-α emission but with photometric redshifts greater than 6 (corresponding to the first billion years of the Universe) have been unsuccessful. Here we identify [C ii] λ = 157.74 μm emission from two sources that we selected as high-redshift candidates on the basis of near-infrared photometry; we confirm that these sources are two galaxies at redshifts of z = 6.8540 ± 0.0003 and z = 6.8076 ± 0.0002. Notably, the luminosity of the [C ii] line from these galaxies is higher than that found previously in star-forming galaxies with redshifts greater than 6.5. The luminous and extended [C ii] lines reveal clear velocity gradients that, if interpreted as rotation, would indicate that these galaxies have similar dynamic properties to the turbulent yet rotation-dominated disks that have been observed in Hα-emitting galaxies two billion years later, at ‘cosmic noon’.

Renske Smit, Rychard J. Bouwens, Stefano Carniani, Pascal A. Oesch, Ivo Labbé, Garth D. Illingworth, Paul van der Werf, Larry D. Bradley, Valentino Gonzalez, Jacqueline A. Hodge + et al.

doi: 10.1038/nature24631

전문 |PDF

An extreme magneto-ionic environment associated with the fast radio burst source FRB 121102 p.182

Polarimetric observations of the repeating fast radio burst source FRB 121102 suggest that the bursts may originate from a neutron star in the extreme magneto-ionic environment of an accreting massive black hole or supernova remnant.

D. Michilli, A. Seymour, J. W. T. Hessels, L. G. Spitler, V. Gajjar, A. M. Archibald, G. C. Bower, S. Chatterjee, J. M. Cordes, K. Gourdji + et al.

doi: 10.1038/nature25149

전문 |PDF

Bright triplet excitons in caesium lead halide perovskites p.189

The lowest-energy exciton state in caesium lead halide perovskite nanocrystals is shown to be a bright triplet state, contrary to expectations that lowest-energy excitons should always be dark.

Michael A. Becker, Roman Vaxenburg, Georgian Nedelcu, Peter C. Sercel, Andrew Shabaev, Michael J. Mehl, John G. Michopoulos, Samuel G. Lambrakos, Noam Bernstein, John L. Lyons + et al.

doi: 10.1038/nature25147

전문 |PDF

Fire frequency drives decadal changes in soil carbon and nitrogen and ecosystem productivity p.194

A meta-analysis and field data show that frequent fires in savannas and broadleaf forests decrease soil carbon and nitrogen over many decades; modelling shows that nitrogen loss drives carbon loss by reducing net primary productivity.

Adam F. A. Pellegrini, Anders Ahlström, Sarah E. Hobbie, Peter B. Reich, Lars P. Nieradzik, A. Carla Staver, Bryant C. Scharenbroch, Ari Jumpponen, William R. L. Anderegg, James T. Randerson + et al.

doi: 10.1038/nature24668

전문 |PDF

Terminal Pleistocene Alaskan genome reveals first founding population of Native Americans p.203

An Ancient Beringian population from Late Pleistocene Alaska and the ancestors of other Native American groups descended from a single founding population that diversified around twenty thousand years ago.

J. Víctor Moreno-Mayar, Ben A. Potter, Lasse Vinner, Matthias Steinrücken, Simon Rasmussen, Jonathan Terhorst, John A. Kamm, Anders Albrechtsen, Anna-Sapfo Malaspinas, Martin Sikora + et al.

doi: 10.1038/nature25173

전문 |PDF

Precision editing of the gut microbiota ameliorates colitis p.208

Tungstate inhibits molybdenum-cofactor-dependent microbial respiratory pathways and shows potential as a selective treatment for microbial imbalances that occur during inflammation of the gastrointestinal tract.

Wenhan Zhu, Maria G. Winter, Mariana X. Byndloss, Luisella Spiga, Breck A. Duerkop, Elizabeth R. Hughes, Lisa Büttner, Everton de Lima Romão, Cassie L. Behrendt, Christopher A. Lopez + et al.

doi: 10.1038/nature25172

전문 |PDF

Clonal analysis of lineage fate in native haematopoiesis p.212

Transposon tagging to clonally trace progenitors and stem cells provides evidence for a substantially revised roadmap for unperturbed haematopoiesis, and highlights unique properties of multipotent progenitors and haematopoietic stem cells in situ.

Alejo E. Rodriguez-Fraticelli, Samuel L. Wolock, Caleb S. Weinreb, Riccardo Panero, Sachin H. Patel, Maja Jankovic, Jianlong Sun, Raffaele A. Calogero, Allon M. Klein & Fernando D. Camargo

doi: 10.1038/nature25168

전문 |PDF

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents p.217

CRISPR–Cas9 genome editing is used to correct a dominant-negative mutation in a mouse model of inherited deafness, resulting in improvements in cochlear function and hearing.

Xue Gao, Yong Tao, Veronica Lamas, Mingqian Huang, Wei-Hsi Yeh, Bifeng Pan, Yu-Juan Hu, Johnny H. Hu, David B. Thompson, Yilai Shu + et al.

doi: 10.1038/nature25164

전문 |PDF

A metabolic function of FGFR3-TACC3 gene fusions in cancer p.222

Chromosomal translocations that generate in-frame oncogenic gene fusions are notable examples of the success of targeted cancer therapies1–3. We have previously described gene fusions of FGFR3- TACC3 (F3–T3) in 3% of human glioblastoma cases4. Subsequent studies have reported similar frequencies of F3–T3 in many other cancers, indicating that F3–T3 is a commonly occuring fusion across all tumour types5,6. F3–T3 fusions are potent oncogenes that confer sensitivity to FGFR inhibitors, but the downstream oncogenicsignalling pathways remain unknown2,4–6. Here we show that human tumours with F3–T3 fusions cluster within transcriptional subgroups that are characterized by the activation of mitochondrial functions. F3–T3 activates oxidative phosphorylation and mitochondrial biogenesis and induces sensitivity to inhibitors of oxidative metabolism. Phosphorylation of the phosphopeptide PIN4 is an intermediate step in the signalling pathway of the activation of mitochondrial metabolism. The F3–T3–PIN4 axis triggers the biogenesis of peroxisomes and the synthesis of new proteins. The anabolic response converges on the PGC1α coactivator through the production of intracellular reactive oxygen species, which enables mitochondrial respiration and tumour growth. These data illustrate the oncogenic circuit engaged by F3–T3 and show that F3–T3- positivetumours rely on mitochondrial respiration, highlighting this pathway as a therapeutic opportunity for the treatment of tumours with F3–T3 fusions. We also provide insights into the genetic alterations that initiate the chain of metabolic responses that drive mitochondrial metabolism in cancer.

Véronique Frattini & Stefano M. Pagnotta

doi: 10.1038/nature25171

전문 |PDF

Opening of the human epithelial calcium channel TRPV6 p.233

The cryo-electron microscopy structure of the calcium channel TRPV6 in its open and closed states demonstrates a novel gating mechanism involving an alanine hinge.

Luke L. McGoldrick, Appu K. Singh, Kei Saotome, Maria V. Yelshanskaya, Edward C. Twomey, Robert A. Grassucci & Alexander I. Sobolevsky

doi: 10.1038/nature25182

전문 |PDF