Great mentoring is key for the next generation of scientists p.5
The Nature Awards for Mentoring in Science show that it is crucial to support researchers in leading their groups well.doi: 10.1038/d41586-017-07840-2
Volume 552 Issue 7683
리서치 하이라이트
표지 기사： 자가 조립 DNA 오리가미 어레이를 이용한 모나리자 그림
지구의 현재 에너지 수지에 의해서 추정할 수 있는 미래의 글로벌 온난화
유비쿼틴 기질과 복합체를 형성한 PINK 1에 대한 구조 분석
tRNA에서 유래한 작은 RNA 단편을 통한 리보솜 생합성 조절
수증기 또는 초임계 유체 환경에서 만들어졌을 것으로 추정되는 화성의 진흙 성분
아프리카에 서식하는 말라리아 매개 모기 Anopheles gambiae의 유전적 다양성 분석
RIFIN을 통한 말라리아 기생충의 면역 회피 작용
모체의 연령에 의해서 조절되는 자손 세대에서의 표현형 다양성
T세포성 비호지킨성 림프종을 억제하는 PD-1
컨텐츠
Editorials
Grows well in sun and warmth — and shade and cold p.5
Trees and shrubs could be less fussy about the climate than scientists thought. That might be good news as the planet warms.doi: 10.1038/d41586-017-07841-1
Gene-drive technology needs thorough scrutiny p.6
Scientists must continue to play their part in pointing out the potential environmental dangers.doi: 10.1038/d41586-017-08214-4
News
Archaeologists uneasy as Trump shrinks Bears Ears monument lands p.13
Thousands of ancient Native American sites to lose protections.doi: 10.1038/d41586-017-07794-5
Huge haul of rare pterosaur eggs excites palaeontologists p.14
Embryos found in some fossil eggs suggest that hatchlings struggled to fly.doi: 10.1038/nature.2017.23049
Bat cave solves mystery of deadly SARS virus — and suggests new outbreak could occur p.15
Chinese scientists find all the genetic building blocks of SARS in a single population of horseshoe bats.doi: 10.1038/d41586-017-07766-9
Scientists want in on humanity's next big space station p.16
Space agencies are planning a Deep Space Gateway to orbit the Moon.doi: 10.1038/d41586-017-07869-3
Hundreds of German universities set to lose access to Elsevier journals p.17
Negotiations to reduce journal prices and promote open access are progressing slowly.doi: 10.1038/d41586-017-07817-1
News Features
The labs that forge distant planets here on Earth p.20
High-pressure experiments explore what it might take to make exoplanets habitabledoi: 10.1038/d41586-017-07844-y
News & Views
DNA self-assembly scaled up p.34
DNA can be designed to self-assemble into target shapes, but the size and quantity of objects that can be prepared have been limited. Methods to overcome these problems have now been found.doi: 10.1038/d41586-017-07690-y
A tip of the hat to evolutionary change p.35
The relative roles of biological and environmental factors in driving evolutionary change have been unclear. Now fossil analysis shows that their action depends on where an animal group is in its evolutionary trajectory.doi: 10.1038/d41586-017-07440-0
A steamy proposal for Martian clays p.37
Martian clays present a conundrum: the models proposed to explain their formation require conditions that are not predicted by computational climate simulations. Experiments now suggest an alternative scenario.doi: 10.1038/d41586-017-07661-3
Vivid views of the PINK1 protein p.38
Structures of an unusual enzymatic domain in PINK1 provide insights into how this protein regulates the function of organelles called mitochondria, and how mutations in PINK1 contribute to Parkinson’s disease.doi: 10.1038/d41586-017-07691-x
Two-dimensional tellurium p.40
Materials that consist of just one or a few layers of atoms could have a range of useful applications. Computer simulations now show that the element tellurium might form three such phases, and that they have potentially useful properties.doi: 10.1038/d41586-017-07159-y
The dark side of PD-1 receptor inhibition p.41
Inhibiting the protein PD-1 can activate T cells that trigger immune responses against tumour cells. But it emerges that, in mice, this immunotherapy exacerbates a cancer that involves the T cells themselves. See Letter p.121doi: 10.1038/nature24759
Quantum-teleportation experiments turn 20 p.42
In 1997, it was demonstrated that quantum states can be teleported from one location to a distant one. The discovery had huge consequences for the development of quantum communication and computing.doi: 10.1038/d41586-017-07689-5
Articles
Greater future global warming inferred from Earth’s recent energy budget p.45
Models show that several aspects of Earth’s top-of-atmosphere energy budget and the magnitude of projected global warming are correlated, enabling us to infer that future warming has been underestimated.doi: 10.1038/nature24672
Structure of PINK1 in complex with its substrate ubiquitin p.51
Stabilization of a transient protein kinase–substrate complex using a nanobody provides molecular details about how the Parkinson’s disease-linked protein kinase PINK1 phosphorylates ubiquitin, and suggests new pharmacological strategies.doi: 10.1038/nature24645
A transfer-RNA-derived small RNA regulates ribosome biogenesis p.57
A 22-nucleotide fragment of a transfer RNA regulates translation by binding to the mRNA of a ribosomal protein and increasing its expression, and downregulation of the fragment in patient-derived liver tumour cells reduces tumour growth in mice.doi: 10.1038/nature25005
Letters
Direct detection of a break in the teraelectronvolt cosmic-ray spectrum of electrons and positrons p.63
A direct measurement of cosmic-ray electrons and positrons with unprecedentedly high energy resolution reveals a spectral break at about 0.9 teraelectronvolts, confirming the evidence found by previous indirect measurements.doi: 10.1038/nature24475
Fractal assembly of micrometre-scale DNA origami arrays with arbitrary patterns p.67
Simple assembly rules applied recursively in a multistage assembly process enable the creation of DNA origami arrays with sizes of up to 0.5 square micrometres and with arbitrary patterns.doi: 10.1038/nature24655
Programmable self-assembly of three-dimensional nanostructures from 10,000 unique components p.72
DNA bricks with binding domains of 13 nucleotides instead of the typical 8 make it possible to self-assemble gigadalton-scale, three-dimensional nanostructures consisting of tens of thousands of unique components.doi: 10.1038/nature24648
Gigadalton-scale shape-programmable DNA assemblies p.78
By using DNA sequence information to encode the shapes of DNA origami building blocks, shape-programmable assemblies can be created, with sizes and complexities similar to those of viruses.doi: 10.1038/nature24651
Biotechnological mass production of DNA origami p.84
All necessary strands for DNA origami can be created in a single scalable process by using bacteriophages to generate single-stranded precursor DNA containing the target sequences interleaved with self-excising DNA enzymes.doi: 10.1038/nature24650
Primordial clays on Mars formed beneath a steam or supercritical atmosphere p.88
Many Martian clays formed when Mars’ primary crust reacted with a water/carbon dioxide steam or supercritical atmosphere and subsequent impacts and volcanism caused the distribution of clay exposures seen today.doi: 10.1038/nature24657
Reconciling taxon senescence with the Red Queen’s hypothesis p.92
Focusing attention on the expansion of taxa, rather than their survival, resolves the apparent contradiction between seemingly deterministic patterns of waxing and waning of taxa over time and the randomness of extinction implied by the Red Queen’s hypothesis.doi: 10.1038/nature24656
Genetic diversity of the African malaria vector Anopheles gambiae p.96
Genome sequencing analyses from 765 specimens of Anopheles gambiae and Anopheles coluzzii from 15 locations across Africa characterize patterns of gene flow and variations in population size, and provide a resource for studying the evolution of natural malaria vector populations.doi: 10.1038/nature24995
Immune evasion of Plasmodium falciparum by RIFIN via inhibitory receptors p.101
Proteins expressed on the surfaces of erythrocytes infected with Plasmodium falciparum help the parasite to evade the host immune system by acting as ligands for immune inhibitory receptors and thereby downregulating the immune response.doi: 10.1038/nature24994
Maternal age generates phenotypic variation in Caenorhabditis elegans p.106
Maternal age is found to be a major source of phenotypic variation in isogenic C. elegans populations living in a controlled environment, with the progeny of young mothers impaired for multiple fitness traits.doi: 10.1038/nature25012
IL-11 is a crucial determinant of cardiovascular fibrosis p.110
Fibroblast-specific IL-11 expression causes heart and kidney fibrosis and organ failure, whereas IL-11 inhibition prevents fibroblast activation and organ fibrosis, indicating that IL-11 inhibition is a potential therapeutic strategy to treat fibrotic diseases.doi: 10.1038/nature24676
Inactivation of DNA repair triggers neoantigen generation and impairs tumour growth p.116
The inactivation of DNA mismatch repair in cancer cells produces dynamic mutational profiles and generates neoantigens, which result in improved immune surveillance against these cells.doi: 10.1038/nature24673
PD-1 is a haploinsufficient suppressor of T cell lymphomagenesis p.121
Loss of the PD-1 receptor promotes the development of T cell non-Hodgkin lymphomas by modulating oncogenic signalling pathways, and blocking these pathways reduces tumourigenesis.doi: 10.1038/nature24649
Promoter-bound METTL3 maintains myeloid leukaemia by m6 A-dependent translation control
p.126
N
doi: 10.1038/nature24678
Genetically programmed chiral organoborane synthesis p.132
A genetically encoded platform can produce chiral organoboranes in bacteria with high turnover, enantioselectivity and chemoselectivity, and can be tuned and configured through DNA manipulation.doi: 10.1038/nature24996
