A feat in stem-cell therapy highlights what can be achieved when basic and clinical research combine to advance biological understanding and treatment.
Researchers should recognize communities that feel over-researched and under-rewarded.
The US environment agency should not ban researchers it funds from its advisory boards.
Success for the ‘Arctic apple’ could herald a new wave of lab-grown foods.
Analysis of universities' salary data suggests major disparities in pay for early-career researchers.
The first new species of great ape described in more than eight decades faces threats to its habitat.
Rare move stems from a conflict over two journal articles about renewable energy.
Conclusions of climate-change science analysis are at odds with US President Donald Trump’s policies.
Physicists begin to embrace alternative explanations for the missing material.
As regulators consider a ban on neonicotinoids, debate rages over the harm they cause to bees.
News & Views
A silicon probe that is inserted into the mouse brain can precisely measure the activity of about 200 individual neurons simultaneously. This tool should improve our ability to study functional neuronal circuitry. See Letter p.232
An event that initially resembled an ordinary supernova explosion continued to erupt brightly for more than 600 days. Standard theoretical models cannot explain the event's properties. See Letter p.210
The presence of N1 methyl groups on adenine bases was thought to be widespread in messenger RNAs. It now seems that these modifications are much less prevalent, and occur on mRNAs that structurally mimic transfer RNA. See Letter p.251
Small-molecule organic dyes that fluoresce in the short-wave infrared region of the spectrum could improve the resolution of in vivo bioimaging methods. Such dyes have now been made by adapting those that fluoresce visible light.
Circulation of the ocean's densest waters modulates millennial-scale shifts in climate. Contrary to conventional wisdom, a study finds that the shape of the sea floor constrains where these waters rise towards the surface. See Article p.181
Genetic variation in a neuropeptide signalling pathway regulates age-related declines in health in nematode worms. This discovery points to a mechanism that influences individual differences in ageing. See Article p.198
The geometry of the ocean floor sets key regime transitions in the circulation of deep ocean waters.
Fragmentation of forest ecosystems produces forest edges, which affect the distribution of many analysed vertebrate species; smaller-bodied amphibians, larger reptiles and medium-sized mammals experience a larger reduction in suitable habitat than other forest-core species.
Astrocyte morphogenesis depends on interactions between astrocytic neuroligins and neuronal neurexins.
Identifying the gene polymorphisms that are the foundations of variation in glia–neuron signalling in Caenorhabditis elegans provides insight into highly variable age-related declines in worm behaviours.
Cryo-electron microscopy structures of the yeast pre-initiation complex (PIC) and its complex with core Mediator provide insights into the opening of promoter DNA and the initiation of transcription.
Observations of an event (several energetic eruptions leading to a terminal explosion that is surprisingly hydrogen-rich) with the spectrum of a supernova do not match with other observations of supernovae.
In copper components containing highly oriented nanotwins, correlated ‘necklace’ dislocations moving back and forth offer an unusually fatigue-resistant response to engineering stress.
Stacking-disordered ice crystallites are shown to have an ice nucleation rate much higher than predicted by classical nucleation theory, which needs to be taken into account in cloud modelling.
Analyses of digital corpora of annotated texts reveal the influence of stochastic drift versus selection in grammatical shifts in English and provide a general method for quantitatively testing theories of language change.
Experimental evidence that global Kctd13 reduction leads to increased RhoA levels that reduce synaptic transmission, implicating RhoA as a potential therapeutic target for neuropsychiatric disorders associated with copy-number variants that include KCTD13.
New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents.
The discovery of a visual-looming-sensitive neuron, LPLC2, that provides input to the Drosophila escape pathway, and uses dendrites patterned to integrate directionally selective inputs to selectively encode outward motion.
Nutrient amendment experiments at the boundary of the South Atlantic gyre reveal extensive regions in which nitrogen and iron are co-limiting, with other micronutrients also approaching co-deficiency; such limitations potentially increase phytoplankton community diversity.
Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4.
Transcriptome-wide mapping of N1-methyladenosine (m1A) at single-nucleotide resolution reveals m1A to be scarce in cytoplasmic mRNA, to inhibit translation, and to be highly dynamic at a single site in a mitochondrial mRNA.