네이처 컨텐츠


Skin regeneration with insights p.141

A feat in stem-cell therapy highlights what can be achieved when basic and clinical research combine to advance biological understanding and treatment.

doi: 10.1038/551141a



News Features

News & Views

Neurons recorded en masse p.172

A silicon probe that is inserted into the mouse brain can precisely measure the activity of about 200 individual neurons simultaneously. This tool should improve our ability to study functional neuronal circuitry. See Letter p.232

Edward M. Callaway & Anupam K. Garg

doi: 10.1038/551172a


The star that would not die p.173

An event that initially resembled an ordinary supernova explosion continued to erupt brightly for more than 600 days. Standard theoretical models cannot explain the event's properties. See Letter p.210

Stan Woosley

doi: 10.1038/551173a


Shrinking maps of RNA modifications p.174

The presence of N1 methyl groups on adenine bases was thought to be widespread in messenger RNAs. It now seems that these modifications are much less prevalent, and occur on mRNAs that structurally mimic transfer RNA. See Letter p.251

Anya V. Grozhik & Samie R. Jaffrey

doi: 10.1038/nature24156


Organic dyes for deep bioimaging p.176

Small-molecule organic dyes that fluoresce in the short-wave infrared region of the spectrum could improve the resolution of in vivo bioimaging methods. Such dyes have now been made by adapting those that fluoresce visible light.

Martin J. Schnermann

doi: 10.1038/nature24755


Mixed up at the sea floor p.178

Circulation of the ocean's densest waters modulates millennial-scale shifts in climate. Contrary to conventional wisdom, a study finds that the shape of the sea floor constrains where these waters rise towards the surface. See Article p.181

Andrew L. Stewart

doi: 10.1038/551178b


A genetic cause of age-related decline p.179

Genetic variation in a neuropeptide signalling pathway regulates age-related declines in health in nematode worms. This discovery points to a mechanism that influences individual differences in ageing. See Article p.198

Patrick T. McGrath

doi: 10.1038/551179a



Creation of forest edges has a global impact on forest vertebrates p.187

Fragmentation of forest ecosystems produces forest edges, which affect the distribution of many analysed vertebrate species; smaller-bodied amphibians, larger reptiles and medium-sized mammals experience a larger reduction in suitable habitat than other forest-core species.

M. Pfeifer, V. Lefebvre, C. A. Peres, C. Banks-Leite, O. R. Wearn, C. J. Marsh, S. H. M. Butchart, V. Arroyo-Rodríguez, J. Barlow, A. Cerezo + et al.

doi: 10.1038/nature24457

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Energetic eruptions leading to a peculiar hydrogen-rich explosion of a massive star p.210

Observations of an event (several energetic eruptions leading to a terminal explosion that is surprisingly hydrogen-rich) with the spectrum of a supernova do not match with other observations of supernovae.

Iair Arcavi, D. Andrew Howell, Daniel Kasen, Lars Bildsten, Griffin Hosseinzadeh, Curtis McCully, Zheng Chuen Wong, Sarah Rebekah Katz, Avishay Gal-Yam, Jesper Sollerman + et al.

doi: 10.1038/nature24030

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Role of stacking disorder in ice nucleation p.218

Stacking-disordered ice crystallites are shown to have an ice nucleation rate much higher than predicted by classical nucleation theory, which needs to be taken into account in cloud modelling.

Laura Lupi, Arpa Hudait, Baron Peters, Michael Grünwald, Ryan Gotchy Mullen, Andrew H. Nguyen & Valeria Molinero

doi: 10.1038/nature24279

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Detecting evolutionary forces in language change p.223

Analyses of digital corpora of annotated texts reveal the influence of stochastic drift versus selection in grammatical shifts in English and provide a general method for quantitatively testing theories of language change.

Mitchell G. Newberry, Christopher A. Ahern, Robin Clark & Joshua B. Plotkin

doi: 10.1038/nature24455

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Kctd13 deletion reduces synaptic transmission via increased RhoA p.227

Experimental evidence that global Kctd13 reduction leads to increased RhoA levels that reduce synaptic transmission, implicating RhoA as a potential therapeutic target for neuropsychiatric disorders associated with copy-number variants that include KCTD13.

Christine Ochoa Escamilla, Irina Filonova, Angela K. Walker, Zhong X. Xuan, Roopashri Holehonnur, Felipe Espinosa, Shunan Liu, Summer B. Thyme, Isabel A. López-García, Dorian B. Mendoza + et al.

doi: 10.1038/nature24470

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Fully integrated silicon probes for high-density recording of neural activity p.232

New silicon probes known as Neuropixels are shown to record from hundreds of neurons simultaneously in awake and freely moving rodents.

James J. Jun, Nicholas A. Steinmetz, Joshua H. Siegle, Daniel J. Denman, Marius Bauza, Brian Barbarits, Albert K. Lee, Costas A. Anastassiou, Alexandru Andrei, Çağatay Aydın + et al.

doi: 10.1038/nature24636

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Ultra-selective looming detection from radial motion opponency p.237

The discovery of a visual-looming-sensitive neuron, LPLC2, that provides input to the Drosophila escape pathway, and uses dendrites patterned to integrate directionally selective inputs to selectively encode outward motion.

Nathan C. Klapoetke, Aljoscha Nern, Martin Y. Peek, Edward M. Rogers, Patrick Breads, Gerald M. Rubin, Michael B. Reiser & Gwyneth M. Card

doi: 10.1038/nature24626

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Nutrient co-limitation at the boundary of an oceanic gyre p.242

Nutrient amendment experiments at the boundary of the South Atlantic gyre reveal extensive regions in which nitrogen and iron are co-limiting, with other micronutrients also approaching co-deficiency; such limitations potentially increase phytoplankton community diversity.

Thomas J. Browning, Eric P. Achterberg, Insa Rapp, Anja Engel, Erin M. Bertrand, Alessandro Tagliabue & C. Mark Moore

doi: 10.1038/nature24063

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Drug-tolerant persister cancer cells are vulnerable to GPX4 inhibition p.247

Cancer persister cells, which survive cytotoxic treatments, are shown to be sensitive to inhibition of the lipid hydroperoxidase GPX4.

Matthew J. Hangauer, Vasanthi S. Viswanathan, Matthew J. Ryan, Dhruv Bole, John K. Eaton, Alexandre Matov, Jacqueline Galeas, Harshil D. Dhruv, Michael E. Berens, Stuart L. Schreiber + et al.

doi: 10.1038/nature24297

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The m1A landscape on cytosolic and mitochondrial mRNA at single-base resolution p.251

Transcriptome-wide mapping of N1-methyladenosine (m1A) at single-nucleotide resolution reveals m1A to be scarce in cytoplasmic mRNA, to inhibit translation, and to be highly dynamic at a single site in a mitochondrial mRNA.

Modi Safra, Aldema Sas-Chen, Ronit Nir, Roni Winkler, Aharon Nachshon, Dan Bar-Yaacov, Matthias Erlacher, Walter Rossmanith, Noam Stern-Ginossar & Schraga Schwartz

doi: 10.1038/nature24456

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