Global regulations to limit carbon dioxide from the shipping industry are overdue.
Scientists have written another chapter in the curious case of the composer’s heart. But it is unlikely to be the end of the story.
A look at what we have published highlights the variety of editorial judgements in selecting and assessing papers.
Scientists scramble to avert disruption to data set that has tracked polar ice since the late 1970s.
Hints emerge that past environments could have influenced psychiatric disorders.
Critics say selection process for high-stakes funding programme is flawed.
A group of volunteers claims that the organization that spearheaded global protests in April has been unduly secretive about its management practices.
Feathered carnivore was dark on top and light underneath, with a raccoon-like face.
Pilot projects aim to pinpoint how benign tumours turn into lung, breast, prostate and pancreatic cancers.
Experiments are starting to probe the limits of the classical laws of thermodynamics.
News & Views
The discovery of gravitational waves from a neutron-star merger and the detection of the event across the electromagnetic spectrum give insight into many aspects of gravity and astrophysics. See Letter p.64, p.67, p.71, p.75 & p.80
What came first: oxygen-producing photosynthesis, or compounds that protect cells from oxygen-induced damage? It emerges that one such compound might have been produced in microbes before Earth's oxygenation.
Removing the protein complex cohesin from chromosomes destroys one layer of the genome's 3D structure but leaves another intact. Genome structure is therefore built by independent processes that work together. See Letter p.51
In nuclear fusion, energy is produced by the rearrangement of protons and neutrons. The discovery of an analogue of this process involving particles called quarks has implications for both nuclear and particle physics. See Letter p.89
Schwann cells support neuronal signalling. The discovery that these cells become dramatically reprogrammed after nerve injury, adopting migratory characteristics that promote repair, highlights the plasticity of mature cell types.
Ecological interactions emerge spontaneously in an experimental study of bacterial populations cultured for 60,000 generations, and sustain rapid evolution by natural selection. See Letter p.45
Using data from sixty thousand generations of the E. coli long-term evolution experiment, the authors shed new light on the processes that govern molecular evolution.
Depletion of chromosome-associated cohesin leads to loss of topologically associating domains in interphase chromosomes, without affecting segregation into compartments, and instead, it unmasks a finer compartment structure that reflects local chromatin and transcriptional activity.
Single-particle cryo-electron microscopy is used to resolve the structure of the phycobilisome, a 16.8-megadalton light-harvesting megacomplex, from the red alga Griffithsia pacifica at a resolution of 3.5 Å.
Optical to near-infrared observations of a transient coincident with the detection of the gravitational-wave signature of a binary neutron-star merger and a low-luminosity short-duration γ-ray burst are presented and modelled.
Observations of the transient associated with the gravitational-wave event GW170817 and γ-ray burst GRB 170817A reveal a bright kilonova with fast-moving ejecta, including lanthanides synthesized by rapid neutron capture.
Detection of X-ray emission at a location coincident with the kilonova transient of the gravitational-wave event GW170817 provides the missing observational link between short γ-ray bursts and gravitational waves from neutron-star mergers.
Observations and modelling of an optical transient counterpart to a gravitational-wave event and γ-ray burst reveal that neutron-star mergers produce gravitational waves and radioactively powered kilonovae, and are a source of heavy elements.
Modelling the electromagnetic emission of kilonovae enables the mass, velocity and composition (with some heavy elements) of the ejecta from a neutron-star merger to be derived from the observations.
The astronomical event GW170817, detected in gravitational and electromagnetic waves, is used to determine the expansion rate of the Universe, which is consistent with and independent of existing measurements.
Two singly charmed baryons can fuse into the recently discovered doubly charmed baryon and a neutron through an exothermic reaction analogous to the nuclear fusion between deuterium and tritium.
Association analysis identifies 65 new breast cancer risk loci, predicts target genes for known risk loci and demonstrates a strong overlap with somatic driver genes in breast tumours.
Highly parallel single-cell transcriptome profiling of Plasmodium falciparum blood stages provides insight into the role AP2-G plays in early sexual development of this eukaryotic pathogen.
Single-cell transcriptomics analyses of cell intermediates during the reprogramming from fibroblast to cardiomyocyte were used to reconstruct the reprogramming trajectory and to uncover intermediate cell populations, gene pathways and regulators involved in this process.
TGFβ signalling regulates T helper 17 (TH17) cell differentiation by reversing SKI–SMAD4-mediated suppression of RORγt, revealing a potential therapeutic target for treating TH17-related diseases.
Interleukin-1 receptor 8 (IL-1R8), a negative regulator of the IL-1 family of cytokines, restrains the activity of natural killer (NK) cells, suggesting that IL-1R8 acts as a checkpoint regulator of NK cell activation and that its blockade may be of use in cancer therapy.
Metabolic flux analysis in mice reveals that lactate often acts as the primary carbon source for the tricarboxylic acid cycle both in normal tissues and in tumour microenvironments.
A new approach to modelling bacterial growth removes the need to know kinetic parameters for metabolic and regulatory processes and can be used to model adaptive processes such as antibiotic responses and ecological dynamics.
The seed-specific transcription factor LEC1 promotes an active chromatin state at the floral repressor FLC and activates its expression in the Arabidopsis pro-embryo, thus reversing the winter cold-induced silenced state that is inherited from gametes.