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To stay young, kill zombie cells p.448

Killing off cells that refuse to die on their own has proved a powerful anti-ageing strategy in mice. Now it's about to be tested in humans.

doi: 10.1038/550448a

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News & Views

Memory beyond immunity p.460

Epithelial stem cells maintain the skin's epidermis and promote wound healing in response to injury. Scientists from two fields discuss implications of the discovery that these stem cells harbour a memory of previous injuries, which enables skin to respond rapidly to subsequent assaults. See Article p.475

Xing Dai & Ruslan Medzhitov

doi: 10.1038/nature24154

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Atomistic views of deformation p.461

Laser experiments and computer simulations have been used to analyse the jiggling of atoms in compressed solids. The results take us closer to designing materials that can withstand extreme conditions. See Letters p.492 & p.496

Neil K. Bourne

doi: 10.1038/550461a

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Origins in the oesophagus p.463

The cellular origins of a precancerous condition called Barrett's oesophagus have been unclear. Tracking and analysis of epithelial cells at the affected site could shed light on the problem. See Letter p.529

Lizhe Zhuang & Rebecca C. Fitzgerald

doi: 10.1038/nature24150

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Rapid mass changes measured in cells p.465

An ultrasensitive balance has been developed to weigh single or multiple cells, at high time and mass resolution — revealing fast and subtle mass fluctuations during the cell cycle and viral infection. See Letter p.500

David Alsteens & Yves F. Dufrêne

doi: 10.1038/550465a

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Twenty years of drying droplets p.466

When a particle-laden droplet evaporates on a solid surface, the particles form a ring-like deposit. The explanation for this phenomenon, provided in 1997, has led to advances in many areas of science and engineering.

Ronald G. Larson

doi: 10.1038/550466a

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How flowers get the blues to lure bees p.467

The petals of a range of flowers harbour repeated patterns of nanostructures that show similar levels of disorder across species. This degree of disorder produces a blue halo of scattered light that helps bees to find flowers. See Article p.469

Dimitri D. Deheyn

doi: 10.1038/nature24155

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Articles

Disorder in convergent floral nanostructures enhances signalling to bees p.469

Disordered nanoscale striations on petals, tepals and bracts have evolved multiple times among flowering plants and provide a salient visual signal to foraging bumblebees (Bombus terrestris).

Edwige Moyroud, Tobias Wenzel, Rox Middleton, Paula J. Rudall, Hannah Banks, Alison Reed, Greg Mellers, Patrick Killoran, M. Murphy Westwood, Ullrich Steiner + et al.

doi: 10.1038/nature24285

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Inflammatory memory sensitizes skin epithelial stem cells to tissue damage p.475

After acute inflammation, epithelial stem cells retain a memory that accelerates restoration of the skin barrier during subsequent tissue damage, and this enhancement is dependent on the AIM2 inflammasome and its downstream effectors.

Shruti Naik, Samantha B. Larsen, Nicholas C. Gomez, Kirill Alaverdyan, Ataman Sendoel, Shaopeng Yuan, Lisa Polak, Anita Kulukian, Sophia Chai & Elaine Fuchs

doi: 10.1038/nature24271

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Molecular basis of USP7 inhibition by selective small-molecule inhibitors p.481

Small molecules are identified that inhibit the ubiquitin-specific protease USP7 with high affinity and specificity as explained by co-crystal structures, and are shown to reduce tumour growth in mice.

Andrew P. Turnbull, Stephanos Ioannidis, Wojciech W. Krajewski, Adan Pinto-Fernandez, Claire Heride, Agnes C. L. Martin, Louise M. Tonkin, Elizabeth C. Townsend, Shane M. Buker, David R. Lancia + et al.

doi: 10.1038/nature24451

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Letters

In situ X-ray diffraction measurement of shock-wave-driven twinning and lattice dynamics p.496

In situ femtosecond X-ray diffraction measurements reveal that the dominant mechanism of shock-wave-driven deformation in tantalum changes from twinning to dislocation slip as pressure increases.

C. E. Wehrenberg, D. McGonegle, C. Bolme, A. Higginbotham, A. Lazicki, H. J. Lee, B. Nagler, H.-S. Park, B. A. Remington, R. E. Rudd + et al.

doi: 10.1038/nature24061

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Inertial picobalance reveals fast mass fluctuations in mammalian cells p.500

A picobalance consisting of an optically excited microcantilever has been developed and used to measure the masses of individual healthy and virus-infected cells at high temporal and mass resolutions in culture conditions.

David Martínez-Martín, Gotthold Fläschner, Benjamin Gaub, Sascha Martin, Richard Newton, Corina Beerli, Jason Mercer, Christoph Gerber & Daniel J. Müller

doi: 10.1038/nature24288

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Indirect effects drive coevolution in mutualistic networks p.511

An approach to ecological interactions that integrates coevolutionary dynamics and network structure, showing that selection in mutualisms is shaped not only by the mutualistic partners but also by all sorts of indirect effects from other species in the network.

Paulo R. Guimarães, Mathias M. Pires, Pedro Jordano, Jordi Bascompte & John N. Thompson

doi: 10.1038/nature24273

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The prevalence of Plasmodium falciparum in sub-Saharan Africa since 1900 p.515

Spatial and temporal modelling of a large dataset of Plasmodium falciparum prevalence rates reveals cycles and trends of malaria transmission in sub-Saharan Africa over a 115 year period.

Robert W. Snow, Benn Sartorius, David Kyalo, Joseph Maina, Punam Amratia, Clara W. Mundia, Philip Bejon & Abdisalan M. Noor

doi: 10.1038/nature24059

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Mfsd2b is essential for the sphingosine-1-phosphate export in erythrocytes and platelets p.524

Identification of a transmembrane protein, Mfsd2b, that is essential for the export of the signalling molecule sphingosine-1-phosphate (S1P) from red blood cells and platelets.

Thiet M. Vu, Ayako-Nakamura Ishizu, Juat Chin Foo, Xiu Ru Toh, Fangyu Zhang, Ding Ming Whee, Federico Torta, Amaury Cazenave-Gassiot, Takayoshi Matsumura, Sangho Kim + et al.

doi: 10.1038/nature24053

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Transitional basal cells at the squamous–columnar junction generate Barrett’s oesophagus p.529

Barrett’s oesophagus—a metaplasia that can be induced by persistent acid reflux, and predisposes patients to oesophageal cancer—arises from a population of basal cells at the gastro-oesophageal junction.

Ming Jiang, Haiyan Li, Yongchun Zhang, Ying Yang, Rong Lu, Kuancan Liu, Sijie Lin, Xiaopeng Lan, Haikun Wang, Han Wu + et al.

doi: 10.1038/nature24269

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Single-molecule imaging reveals receptor–G protein interactions at cell surface hot spots p.543

G-protein-coupled receptors mediate the biological effects of many hormones and neurotransmitters and are important pharmacological targets. They transmit their signals to the cell interior by interacting with G proteins. However, it is unclear how receptors and G proteins meet, interact and couple. Here we analyse the concerted motion of G-protein-coupled receptors and G proteins on the plasma membrane and provide a quantitative model that reveals the key factors that underlie the high spatiotemporal complexity of their interactions. Using two-colour, single-molecule imaging we visualize interactions between individual receptors and G proteins at the surface of living cells. Under basal conditions, receptors and G proteins form activity-dependent complexes that last for around one second. Agonists specifically regulate the kinetics of receptor–G protein interactions, mainly by increasing their association rate. We find hot spots on the plasma membrane, at least partially defined by the cytoskeleton and clathrin-coated pits, in which receptors and G proteins are confined and preferentially couple. Imaging with the nanobody Nb37 suggests that signalling by G-protein-coupled receptors occurs preferentially at these hot spots. These findings shed new light on the dynamic interactions that control G-protein-coupled receptor signalling.

Titiwat Sungkaworn, Marie-Lise Jobin, Krzysztof Burnecki, Aleksander Weron, Martin J. Lohse & Davide Calebiro

doi: 10.1038/nature24264

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