Volume 550 Number 7676

Editorials

News

News Features

The future of work p.315

Digital technologies are upending the workforce. The right research can tell us how.

doi: 10.1038/550315a

News & Views

Learning to play Go from scratch p.336

An artificial-intelligence program called AlphaGo Zero has mastered the game of Go without any human data or guidance. A computer scientist and two members of the American Go Association discuss the implications. See Article p.354

doi: 10.1038/550336a

Bacterial snack attack deactivates a drug p.337

Tumour cells can develop intrinsic adaptations that make them less susceptible to chemotherapy. It emerges that extrinsic bacterial action can also enable tumour cells to escape the effects of drug treatment.

doi: 10.1038/550337a

Data analysis meets quantum physics p.339

A technique that combines machine learning and quantum computing has been used to identify the particles known as Higgs bosons. The method could find applications in many areas of science. See Letter p.375

doi: 10.1038/550339a

Genome jail-break triggers lockdown p.340

A pro-inflammatory response, the senescence-associated secretory phenotype, can affect development, ageing and cancer. It emerges that one trigger for this response is the presence of DNA in the cytoplasm. See Letter p.402

doi: 10.1038/nature24146

Complex assistance for DNA invasion p.342

Repair of broken DNA is vital for genome stability and to prevent the development of cancer. Research shows how the tumour-suppressor protein BRCA1 promotes a DNA-repair pathway called homologous recombination. See Article p.360

doi: 10.1038/nature24149

Domains to the rescue for Rett syndrome p.343

Rett syndrome is a brain disorder caused by disrupted forms of the protein MECP2, but how MECP2 loss affects the brain is unknown. A mouse study now implicates key domains of the protein and offers therapeutic insights. See Letter p.398

doi: 10.1038/nature24151

Review

Articles

Letters

Organic long persistent luminescence p.384

A blend of two organic molecules excited by a simple LED light source can release the stored excitation energy slowly as ‘long persistent luminescence’ over periods of up to an hour.

doi: 10.1038/nature24010

Establishment of mouse expanded potential stem cells p.393

Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.

doi: 10.1038/nature24052