Science must examine the future of work p.301
As automation changes employment, researchers should gather the evidence to help map the implications.doi: 10.1038/550301b
Volume 550 Issue 7676
Editorials
Eye in the sky offers clearest vision of Earth p.301
Time to think about how automation will affect employement.doi: 10.1038/550301a
Blue is in the eye of the bee-holder p.302
Flowers have evolved an ingenious way to attract pollinators.doi: 10.1038/550302a
News
Colliding stars spark rush to solve cosmic mysteries p.309
Stellar collision confirms theoretical predictions about the periodic table.doi: 10.1038/550309a
Japanese research leaders warn about national science decline p.310
Concern mounts over budget cuts and other changes that undermine basic science.doi: 10.1038/550310a
Trump EPA begins push to overturn Obama-era climate regulation p.311
The agency's plan to reverse limits on greenhouse-gas emissions is likely to draw legal challenges.doi: 10.1038/nature.2017.22813
New definitions of scientific units are on the horizon p.312
Metrologists are poised to change how scientists measure the Universe.doi: 10.1038/550312a
FDA advisers back gene therapy for rare form of blindness p.314
Therapy that targets disease-causing mutations could become the first of its kind approved for use in the United States.doi: 10.1038/nature.2017.22819
News Features
The future of work p.315
Digital technologies are upending the workforce. The right research can tell us how.doi: 10.1038/550315a
The shape of work to come p.316
Three ways that the digital revolution is reshaping workforces around the world.doi: 10.1038/550316a
News & Views
Learning to play Go from scratch p.336
An artificial-intelligence program called AlphaGo Zero has mastered the game of Go without any human data or guidance. A computer scientist and two members of the American Go Association discuss the implications. See Article p.354doi: 10.1038/550336a
Bacterial snack attack deactivates a drug p.337
Tumour cells can develop intrinsic adaptations that make them less susceptible to chemotherapy. It emerges that extrinsic bacterial action can also enable tumour cells to escape the effects of drug treatment.doi: 10.1038/550337a
Data analysis meets quantum physics p.339
A technique that combines machine learning and quantum computing has been used to identify the particles known as Higgs bosons. The method could find applications in many areas of science. See Letter p.375doi: 10.1038/550339a
Genome jail-break triggers lockdown p.340
A pro-inflammatory response, the senescence-associated secretory phenotype, can affect development, ageing and cancer. It emerges that one trigger for this response is the presence of DNA in the cytoplasm. See Letter p.402doi: 10.1038/nature24146
Complex assistance for DNA invasion p.342
Repair of broken DNA is vital for genome stability and to prevent the development of cancer. Research shows how the tumour-suppressor protein BRCA1 promotes a DNA-repair pathway called homologous recombination. See Article p.360doi: 10.1038/nature24149
Domains to the rescue for Rett syndrome p.343
Rett syndrome is a brain disorder caused by disrupted forms of the protein MECP2, but how MECP2 loss affects the brain is unknown. A mouse study now implicates key domains of the protein and offers therapeutic insights. See Letter p.398doi: 10.1038/nature24151
Review
DNA sequencing at 40: past, present and future p.345
The history and future potential of DNA sequencing, including the development of the underlying technologies and the expansion of its areas of application, are reviewed.doi: 10.1038/nature24286
Articles
Mastering the game of Go without human knowledge p.354
Starting from zero knowledge and without human data, AlphaGo Zero was able to teach itself to play Go and to develop novel strategies that provide new insights into the oldest of games.doi: 10.1038/nature24270
BRCA1–BARD1 promotes RAD51-mediated homologous DNA pairing p.360
The tumour suppressor complex BRCA1–BARD1, which facilitates the generation of a single-stranded DNA template during homologous recombination, also binds to the recombinase RAD51 and enhances its function.doi: 10.1038/nature24060
Human TRPML1 channel structures in open and closed conformations p.366
Two structures of human transient receptor potential mucolipin 1 (TRPML1), in the closed and agonist-bound open states, have been resolved by electron cryo-microscopy.doi: 10.1038/nature24036
Letters
A parts-per-billion measurement of the antiproton magnetic moment p.371
The magnetic moment of the antiproton is measured at the parts-per-billion level, improving on previous measurements by a factor of about 350.doi: 10.1038/nature24048
Solving a Higgs optimization problem with quantum annealing for machine learning p.375
A machine learning algorithm implemented on a quantum annealer—a D-Wave machine with 1,098 superconducting qubits—is used to identify Higgs-boson decays from background standard-model processes.doi: 10.1038/nature24047
Ion sieving in graphene oxide membranes via cationic control of interlayer spacing p.380
Cations are used to control the interlayer spacing of graphene oxide membranes, enabling efficient and selective sieving of hydrated cations.doi: 10.1038/nature24044
Organic long persistent luminescence p.384
A blend of two organic molecules excited by a simple LED light source can release the stored excitation energy slowly as ‘long persistent luminescence’ over periods of up to an hour.doi: 10.1038/nature24010
Social behaviour shapes hypothalamic neural ensemble representations of conspecific sex p.388
Interactions with male and female intruders activated overlapping neuronal populations in the ventromedial hypothalamus of inexperienced adult male mice, and these ensembles gradually separated as the mice acquired social and sexual experience with conspecifics.doi: 10.1038/nature23885
Establishment of mouse expanded potential stem cells p.393
Cultures of expanded potential stem cells can be established from individual eight-cell blastomeres, and by direct conversion of mouse embryonic stem cells and induced pluripotent stem cells, highlighting the feasibility of establishing expanded potential stem cells for other mammalian species.doi: 10.1038/nature24052
Radically truncated MeCP2 rescues Rett syndrome-like neurological defects p.398
Analysis of the minimal functional unit for MeCP2 protein shows that its function is to recruit the NCoR/SMRT co-repressor complex to methylated sites on chromatin, which may have use in designing strategies for gene therapy of Rett syndrome.doi: 10.1038/nature24058
Cytoplasmic chromatin triggers inflammation in senescence and cancer p.402
Cytoplasmic chromatin activates the innate immunity cytosolic DNA-sensing cGAS–STING pathway, leading both to short-term inflammation to restrain activated oncogenes and to chronic inflammation that associates with tissue destruction and cancer.doi: 10.1038/nature24050
Enhanced proofreading governs CRISPR–Cas9 targeting accuracy p.407
A new engineered version of SpCas9, called HypaCas9, displays enhanced accuracy of editing without significant loss of efficiency at the desired target.doi: 10.1038/nature24268
Cryo-electron microscopy structure of the lysosomal calcium-permeable channel TRPML3 p.411
A cryo-electron microscopy structure shows that the mucolipin domain of the lysosomal calcium channel TRPML3 binds phosphatidylinositol-3,5-bisphosphate and gates the channel.doi: 10.1038/nature24055
Structure of mammalian endolysosomal TRPML1 channel in nanodiscs p.415
The structure of mouse transient receptor potential mucolipin 1 (TRPML1), a cation channel located within endosomal and lysosomal membranes, is resolved using single-particle electron cryo-microscopy.doi: 10.1038/nature24035
