Discoveries have awkward first dates p.7
Fuzzy timings over a plate-tectonics anniversary highlight the rolling nature of scientific discovery.doi: 10.1038/550007a
Volume 550 Issue 7674
리서치 하이라이트
표지 기사： 인간 마이크로바이옴 프로젝트를 통한 미생물종, 기능성, 그리고 다이나믹스
새로운 아미노산을 이용한 유전자 암호의 확장 및 재프로그램화
지놈 교정을 통해 확인된 인간 배아 발달과정에서의 OCT4 유전자 기능
치료제로 개발할 수 있는 새로운 de novo 단백질 제작 방법
하이브리드 Ia형 초신성에서 헬륨 겉껍질 폭발에 의한 초기 섬광
프린트로 출력할 수 있는 유기금속 페브로스카이트를 이용한 저선량 X-선 이미지 촬영
기후 변화에 의한 대규모 빙하 소실과 연관되어 증가하는 그린란드 삼각주
일시적인 공동 서식에 의해 유발된 위도에 따른 식물 다양성의 기울기 현상
비-자가 RNA를 타깃으로 하는 항바이러스 방어 기전을 가동시키는데 관련된 CG 디뉴클레오타이드 억제
컨텐츠
Editorials
http://www.nature.com/doifinder/10.1038/550007b p.7
International mobility and collaboration are linked to stronger research.doi: 10.1038/550007b
Europe’s Joint Research Centre, although improving, must think bigger p.8
External report criticizes lack of exploratory research.doi: 10.1038/550008a
News
Chinese scientists fix genetic disorder in cloned human embryos p.15
A method for precisely editing genes in human embryos hints at a cure for a blood disease.doi: 10.1038/nature.2017.22694
Ethics of Internet research trigger scrutiny p.16
Concern over the use of public data spurs guideline update.doi: 10.1038/550016a
How the latest US travel ban could affect science p.17
Short-term travel and meeting attendance could become harder for researchers from eight countries, including Iran.doi: 10.1038/nature.2017.22686
Medicine Nobel awarded for work on circadian clocks p.18
Jeffrey Hall, Michael Rosbash and Michael Young unpicked molecular workings of cells' daily rhythms.doi: 10.1038/nature.2017.22736
Gravitational wave detection wins physics Nobel p.19
Rainer Weiss, Barry Barish and Kip Thorne share the 2017 prize for their work at LIGO to detect ripples in space-time.doi: 10.1038/nature.2017.22737
Controversial Thirty Meter Telescope gets go-ahead to build in Hawaii p.20
State board issues construction permit for project, but legal fight over telescope continues.doi: 10.1038/nature.2017.22731
News Features
Why fake islands might be a real boon for science p.22
The seasteading movement is getting close to building its first prototype, an artificial archipelago where people will live, play and do research.doi: 10.1038/550022a
How fracking is upending the chemical industry p.26
As shale-gas compounds flood the market, chemists are working out the best ways to convert them into the ingredients of modern life.doi: 10.1038/550026a
News & Views
Zapping viral RNAs p.46
The discovery that the host defence protein ZAP specifically targets viral RNAs that are rich in a particular pair of adjacent bases — cytosine followed by guanine — sheds light on the evolution of viral RNA genomes.doi: 10.1038/nature24140
Material change for X-ray detectors p.47
The X-ray sensitivity of radiology instruments is limited by the materials used in their detectors. A material from the perovskite family of semiconductors could allow lower doses of X-rays to be used for medical imaging. See Letter p.87doi: 10.1038/550047a
A global plan for nature conservation p.48
An international movement is calling for at least half of the Earth to be allocated for conservation. A global study now reveals that, in many ecoregions, enough habitat exists to reach this goal, and ideas are proposed for the next steps needed.doi: 10.1038/nature24144
Computational design hits record resolution p.50
A supercomputer-powered design technique enables the discovery of efficient mechanical structures that have an unprecedented level of detail. The findings provide insights into both physical and biological structures. See Letter p.84doi: 10.1038/550050a
A matter of time for tropical diversity p.51
There is a species-diversity gradient on Earth, with the greatest diversity found near the Equator. Analysis of forest data now reveals a mechanism aiding species coexistence in the tropics that might underlie this phenomenon.doi: 10.1038/nature24142
Review
Expanding and reprogramming the genetic code p.53
A review of the recent developments in reprogramming the genetic code of cells and organisms to include non-canonical amino acids in precisely engineered proteins.doi: 10.1038/nature24031
Articles
Strains, functions and dynamics in the expanded Human Microbiome Project p.61
Updates from the Human Microbiome Project analyse the largest known body-wide metagenomic profile of human microbiome personalization.doi: 10.1038/nature23889
Genome editing reveals a role for OCT4 in human embryogenesis p.67
Genome editing in human zygotes shows that OCT4 is required for normal development at an earlier stage in humans than in mice.doi: 10.1038/nature24033
Massively parallel de novo protein design for targeted therapeutics p.74
A massively parallel computational and experimental approach for de novo designing and screening small hyperstable proteins targeting influenza haemagglutinin and botulinum neurotoxin B identifies new therapeutic candidates more robust than traditional antibody therapies.doi: 10.1038/nature23912
Letters
A hybrid type Ia supernova with an early flash triggered by helium-shell detonation p.80
The detection and simulation of a type Ia supernova with an early, red flash suggests that it formed through detonation of the helium shell of a white dwarf, rather than by collision of the ejecta with a companion star or by merging with another white dwarf.doi: 10.1038/nature23908
Giga-voxel computational morphogenesis for structural design p.84
Giga-voxel-resolution computational morphogenesis is used to optimize the internal structure of a full-scale aeroplane wing, yielding light-weight designs with more similarities to animal bone structures than to current aeroplane wing designs.doi: 10.1038/nature23911
Printable organometallic perovskite enables large-area, low-dose X-ray imaging p.87
Highly sensitive all-solution-based detectors based on printable polycrystalline organometallic perovskite thick films enable X-ray imaging at low radiation doses and over large areas.doi: 10.1038/nature24032
A solvent- and vacuum-free route to large-area perovskite films for efficient solar modules p.92
A new deposition method for solar-panel polycrystalline perovskite thin films enables the production of large-area uniform films and avoids the need for common solvents or vacuum.doi: 10.1038/nature23877
A spin transition mechanism for cooperative adsorption in metal–organic frameworks p.96
Metal–organic frameworks that undergo a cooperative spin transition at neighbouring metal centres upon coordination to CO exhibit large CO separation capacities with only small changes in temperature.doi: 10.1038/nature23674
Delta progradation in Greenland driven by increasing glacial mass loss p.101
Climate change has the potential to erode coastlines, but a rediscovered archive of aerial photographs from the Second World War shows that in southern Greenland, deltas have recently extended seaward.doi: 10.1038/nature23873
Temporal coexistence mechanisms contribute to the latitudinal gradient in forest diversity p.105
High tree species diversity in tropical forests is driven by reduced interspecific competition relative to intraspecific competition, as a result of the asynchronous timing of tree recruitment permitted by long and stable growing seasons.doi: 10.1038/nature24038
Retrograde semaphorin–plexin signalling drives homeostatic synaptic plasticity p.109
Homeostatic signalling systems ensure stable but flexible neural activity and animal behaviour
doi: 10.1038/nature24017
A reversible haploid mouse embryonic stem cell biobank resource for functional genomics p.114
The Haplobank contains over 100,000 individually reversibly mutagenized, barcoded, mouse embryonic cell lines; proof-of-principle experiments were used to search for genes that are required for rhinovirus infection and angiogenesis using forward and reverse genetic screens, respectively.doi: 10.1038/nature24027
Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing p.119
Lipolysis declines with age because NLRP3 inflammasome-activated adipose tissue macrophages reduce levels of noradrenaline by upregulating genes that control its degradation, such as GDF3 and MAOA.doi: 10.1038/nature24022
CG dinucleotide suppression enables antiviral defence targeting non-self RNA p.124
Vertebrate genomes contain fewer CG dinucleotides than would be expected by chance, and this pattern is mimicked by many viruses; HIV-1 derivatives mutated to contain more CG dinucleotides are targeted by the human antiviral protein ZAP, suggesting that CG suppression has evolved in viruses to evade recognition.doi: 10.1038/nature24039
Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours p.128
A potent and selective catalytic inhibitor of p300/CBP histone acetyltransferases suppresses tumour proliferation across multiple cell lineages, illustrating the therapeutic potential of drug-like small molecules that target histone acetyltransferases.doi: 10.1038/nature24028
PAK signalling drives acquired drug resistance to MAPK inhibitors in BRAF-mutant melanomas p.133
BRAF-inhibition resistance in metastatic melanoma occurs through p21-activated kinase-mediated reactivation of ERK, whereas resistance to combined BRAF and MEK inhibition occurs through p21-activated kinase-mediated regulation of JNK and β-catenin phosphorylation, mTOR pathway activation and apoptosis inhibition in many patients.doi: 10.1038/nature24040
How type II CRISPR–Cas establish immunity through Cas1–Cas2-mediated spacer integration p.137
Several structures of the Enteroccocus faecalis Cas1–Cas2 proteins are solved, and help to define the spacer integration mechanisms of type II CRISPR systems.doi: 10.1038/nature24020
