Modelled on big physics projects, the International Brain Lab will bring together some of the world’s pre-eminent neuroscientists to probe a single behaviour.

doi: 10.1038/549319a

전문

News Features

How the Internet of cells has biologists buzzing p.322

Networks of nanotubes may allow cells to share everything from infections and cancer to dementia-linked proteins.

doi: 10.1038/549322a

전문

News & Views

A molecular assembler p.336

The idea of nanometre-scale machines that can assemble molecules has long been thought of as the stuff of science fiction. Such a machine has now been built — and might herald a new model for organic synthesis. See Letter p.374

doi: 10.1038/549336a

전문

Red alert about lipid's role in skin cancer p.337

Some versions of the MC1R protein are associated with red hair and an increased risk of developing a skin cancer called melanoma. It emerges that a lipid that binds MC1R might provide a target to reduce this risk. See Letter p.399

doi: 10.1038/nature23550

전문

Long-lived electrodes for plastic batteries p.339

Organic materials are potential substitutes for the costly transition-metal oxides used in battery electrodes, but their stability is often poor. A polymer design that uses intermolecular interactions solves this problem.

doi: 10.1038/549339a

전문

From embryo mutation to adult degeneration p.340

Mutations in embryonic blood-cell precursors called erythro-myeloid progenitors cause abnormal activation of their descendants — immune cells called microglia — leading to neurodegeneration in mice. See Letter p.389

doi: 10.1038/nature23547

전문

No more tears for metal 3D printing p.342

3D printing could revolutionize manufacturing processes involving metals, but few industrially useful alloys are compatible with the technique. A method has been developed that might open up the 3D printing of all metals. See Letter p.365

doi: 10.1038/549342a

전문

The persistence of memory p.343

Live imaging reveals that whether or not a daughter cell proliferates is influenced by two molecular factors inherited from its mother, providing insight into how the behaviour of a newly born cell can be predetermined. See Letter p.404

doi: 10.1038/nature23549

전문

Articles

Rabies screen reveals GPe control of cocaine-triggered plasticity p.345

A rabies virus-based monosynaptic tracing method is used to show that the external globus pallidus plays a critical role in cocaine-induced behavioural plasticity.

doi: 10.1038/nature23888

전문

PDF

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation p.351

Neuromedin receptor NMUR1 is specifically expressed by a subpopulation of type 2 innate lymphoid cells and promotes the inflammatory response of these cells in response to allergens, indicating the importance of neuro-immune crosstalk in allergic responses.

doi: 10.1038/nature24029

전문

PDF

Letters

A binary main-belt comet p.357

Analysis based on high-resolution observations from the Hubble Space Telescope shows that the asteroid 288P is a binary main-belt comet, with properties unlike any known binary asteroid.

doi: 10.1038/nature23892

전문

PDF

Tunable interacting composite fermion phases in a half-filled bilayer-graphene Landau level p.360

Various fractional quantum Hall phases are observed in a new generation of bilayer-graphene-based van der Waals heterostructures, including an even-denominator state predicted to harbour non-Abelian anyons.

doi: 10.1038/nature23893

전문

PDF

3D printing of high-strength aluminium alloys p.365

Zirconium nanoparticles introduced into aluminium alloy powders control solidification during 3D printing, enabling the production of crack-free materials with strengths comparable to the corresponding wrought material.

doi: 10.1038/nature23894

전문

PDF

Metallic molybdenum disulfide nanosheet-based electrochemical actuators p.370

Electrochemical actuators based on exfoliated and restacked metallic MoS₂ nanosheet electrodes can generate mechanical force in electrolyte solution on intercalation and deintercalation of ions.

doi: 10.1038/nature23668

전문

PDF

Stereodivergent synthesis with a programmable molecular machine p.374

A molecular machine that can be programmed to position a substrate at one of two directing sites on a molecule, which control the stereochemistry of addition to the substrate, demonstrates complexity, precision and function previously only observed in nature.

doi: 10.1038/nature23677

전문

PDF

The Apostasia genome and the evolution of orchids OPEN p.379

Comparing the whole genome sequence of Apostasia shenzhenica with transcriptome and genome data from five orchid subfamilies permits the reconstruction of an ancestral gene toolkit, providing insight into orchid origins, evolution and diversification.

doi: 10.1038/nature23897

전문

PDF

Hippocampal LTP and contextual learning require surface diffusion of AMPA receptors p.384

Surface diffusion of AMPA receptors, from extra-synaptic to synaptic sites at the plasma membrane, is essential for full long-term potentiation in hippocampal neurons and for fear conditioning in living mice.

doi: 10.1038/nature23658

전문

PDF

A somatic mutation in erythro-myeloid progenitors causes neurodegenerative disease p.389

Braf ^V600E expression in resident macrophage progenitors leads to clonal expansion of ERK-activated microglia, which causes synaptic and neuronal loss in the brain and results in lethal neurodegenerative disease in adult mice.

doi: 10.1038/nature23672

전문

PDF

cGAS senses long and HMGB/TFAM-bound U-turn DNA by forming protein–DNA ladders p.394

A molecular mechanism for the sensitive detection of long and U-turn DNA by cyclic GMP–AMP synthase (cGAS) both in vitro and in human cells.

doi: 10.1038/nature23890

전문

PDF

Palmitoylation-dependent activation of MC1R prevents melanomagenesis p.399

The protein modification palmitoylation increases the ability of variant forms of the melanocortin-1 receptor (MC1R) to induce pigmentation, and this is linked to reduced development of melanomas.

doi: 10.1038/nature23887

전문

PDF

Competing memories of mitogen and p53 signalling control cell-cycle entry p.404

Mother cells transmit mitogen-induced CCND1 mRNA and DNA damage-induced p53 protein to newly born daughter cells, where synthesized cyclin D1 and the p53-regulated CDK inhibitor p21 directly compete to decide between proliferation and quiescence.

doi: 10.1038/nature23880

전문

PDF

Alternative evolutionary histories in the sequence space of an ancient protein p.409

Combining ancestral protein reconstruction with deep mutational scanning to characterize alternative histories in the sequence space around an ancient transcription factor reveals hundreds of alternative protein sequences that use diverse biochemical mechanisms to perform the derived function at least as well as the historical outcome.

doi: 10.1038/nature23902

전문

PDF

The cryo-electron microscopy structure of human transcription factor IIH p.414

The cryo-electron microscopy structure of the ten-subunit human transcription factor IIH, revealing the molecular architecture of the TFIIH core complex, the detailed structures of its constituent XPB and XPD ATPases, and how the core and kinase subcomplexes of TFIIH are connected.

doi: 10.1038/nature23903

전문

PDF