Antiskyrmion offers promise for superfast spintronic computers.
Antiskyrmion offers promise for superfast spintronic computers.
Sports organizations are only starting to understand the harm that can be inflicted by high-contact activities. Science must play its part in highlighting the problem and in aiding diagnosis.
Mixing artificial intelligence with climate science helps researchers to identify previously unknown atmospheric processes and rank climate models.
Brightness of exploding stars may vary more than researchers realized.
Scientists say the move will reduce the country’s capacity to predict future ecosystem changes.
Simulations follow how swirls in a fluid transfer and dissipate energy.
Efforts to relocate artefacts to sites of origin could stall after gold robbery at national park.
Scientists investigate why mountain slopes can slip slowly for years and then suddenly speed up, with potentially fatal effects.
Cells called astrocytes promote and maintain neuronal function. The discovery that astrocytes vary in their gene expression, protein levels, cellular structure and function suggests that they are specialized to support distinct circuits.
Four probable detections of gravitational waves have so far been reported, each associated with the merger of two black holes. Analysis of the signals allows formation theories of such black-hole systems to be tested. See Letter p.426
The gene-editing technology CRISPR–Cas has been used in human embryos grown in vitro to correct a disease-associated mutation. The introduction of editing components at fertilization aided repair efficiency. See Article p.413
Single-molecule magnets have potential data-storage applications, but will need to work at a much higher temperature than has been possible. Two studies suggest that this goal could be met in the near future. See Letter p.439
Analysis of wing variation within and between fly species reveals an unexpectedly slow evolutionary rate. Variations due to mutation and interspecific differences are similar, perhaps as a result of complex genetic interactions. See Letter p.447
An analysis of 12,000-year-old Antarctic ice revises our understanding of natural methane emissions to the atmosphere, and constrains estimates of the sensitivity of natural methane sources to abrupt climate-warming events. See Letter p.443
A major cause of death and disease in babies is the failure of their developing immune systems to block life-threatening infections. A clinical trial reports that the use of a probiotic can help to prevent such infections. See Article p.407
A synbiotic preparation of Lactobacillus plantarum and fructooligosaccharide was found to significantly reduce sepsis and infections of the lower respiratory tract in a trial involving newborns from rural India.
CRISPR–Cas9 genome editing is used to induce a DNA repair response and correct a disease-causing heterozygous mutation in human embryos with reduced mosaicism and preferential repair using the wild-type copy of the gene.
An atomic model of the primed pre-fusion SNARE–complexin–synaptotagmin-1 complex in neuronal exocytosis accounting for vesicle priming and cooperation in synchronizing and activating evoked release on the sub-millisecond timescale.
The spins of the black holes involved in each of the four mergers that have been detected in gravitational waves so far were either small or not aligned with the binary orbit.
Starburst galaxies at the peak of cosmic star formation
A finely tuned growth strategy to generate nanowire networks that fulfil all the prerequisites for braiding may lead to a demonstration of Majorana braiding.
Magnetic hysteresis is observed in a dysprosocenium complex at temperatures of up to 60 kelvin, the origin of which is the localized metal–ligand vibrational modes unique to dysprosocenium.
Methane (CH4) is a powerful greenhouse gas and plays a key part in global atmospheric chemistry. Natural geological emissions (fossil methane vented naturally from marine and terrestrial seeps and mud volcanoes) are thought to contribute around 52 teragrams of methane per year to the global methane source, about 10 per cent of the total, but both bottom-up methods (measuring emissions)
A detailed analysis of fly wing phenotypes reveals a strong positive relationship between variation produced by mutation, standing genetic variation, and evolutionary rate over the past 40 million years.
Myofibroblast-derived R-spondin 3 orchestrates regeneration of antral stomach epithelium via Wnt signalling in Axin2+ stem cells.
Developmental deconvolution of complex organs and tissues at the level of individual cells remains challenging. Non-invasive genetic fate mapping1 has been widely used, but the low number of distinct fluorescent marker proteins limits its resolution. Much higher numbers of cell markers have been generated using viral integration sites2, viral barcodes3, and strategies based on transposons4 and CRISPR–Cas9 genome editing5; however, temporal and tissuespecific induction of barcodes
The cytoplasmic DNA sensor cGAS detects DNA in ruptured micronuclei and activates an innate immune response.
The authors report a link between mitosis, the formation of micronuclei and DNA-damage-induced cGAS-dependent inflammation.
Mouse models of breast carcinoma and other solid tumours show that selective cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitors not only induce tumour cell cycle arrest but also promote anti-tumour immunity.
A vaccine-driven approach shows that the prominent stimulant features of the psychoactive profile of fenethylline can be attributed to amphetamine, with synergistic support from theophylline, and no direct contributions from the parent drug molecule.
G-protein-coupled receptors (GPCRs) pose challenges for drug discovery efforts because of the high degree of structural homology in the orthosteric pocket, particularly for GPCRs within a single subfamily, such as the nine adrenergic receptors. Allosteric ligands may bind to less-conserved regions of these receptors and therefore are more likely to be selective. Unlike orthosteric ligands, which tonically activate or inhibit signalling, allosteric ligands modulate physiologic responses to hormones and neurotransmitters, and may therefore have fewer adverse effects. The majority of GPCR crystal structures published to date were obtained with receptors bound to orthosteric antagonists, and only a few structures bound to allosteric ligands have been reported. Compound 15 (Cmpd-15) is an allosteric modulator of the β2 adrenergic receptor (β2AR) that was recently isolated from a DNA-encoded small-molecule library