네이처 컨텐츠

Editorials

Drug approval needs a helping hand p.135

It’s time for researchers to lend their expertise to expediting the arrival of cutting-edge therapies that are waiting in the wings.

doi: 10.1038/548135a

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News

News Features

News & Views

Skull secrets of an ancient ape p.160

Fossil evidence is scarce for early stages of evolution in the ape family tree at the time before apes and the ancestors of humans diverged. A 13-million-year-old skull now offers insights into ape development at that time. See Article p.169

Brenda R. Benefit

doi: 10.1038/548160a

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Optical sensing gets exceptional p.161

Conventional sensors based on devices called optical resonators have fundamentally limited sensitivity. Careful engineering has been used to overcome this constraint, opening the door to ultraprecise sensing. See Letters p.187 & p.192

Mikael C. Rechtsman

doi: 10.1038/548161a

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Click and discover p.162

Details of the activity of promising anticancer drugs known as BET inhibitors remain elusive. An approach called click chemistry enables in-depth analysis of how these drugs modulate the function of a crucial target protein, BRD4.

George S. Vassiliou & Shankar Balasubramanian

doi: 10.1038/548162a

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Trends in ecosystem recovery from drought p.164

An analysis suggests that the time taken for ecosystems to recover from drought increased during the twentieth century. If the frequency of drought events rises, some ecosystems might never have the chance to fully recover. See Letter p.202

Sonia I. Seneviratne & Philippe Ciais

doi: 10.1038/548164a

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The cost of perpetual youth p.165

The ability to become nearly any cell type is restricted to eggs, sperm and primitive stem cells in very early embryos. Two studies reveal that maintaining this pluripotent state in vitro comes at a cost. See Letters p.219 & p.224

Thomas P. Zwaka

doi: 10.1038/nature23102

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Contests between species aid biodiversity p.166

A modelling approach used to investigate competition between different species provides insight into how contests that have multiple players can help to maintain biodiversity. See Letter p.210

James P. O'Dwyer

doi: 10.1038/nature23103

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Articles

New infant cranium from the African Miocene sheds light on ape evolution p.169

Description of the most complete fossil skull of an infant ape recovered from the Miocene epoch of Kenya, assigned to a new species in the genus Nyanzapithecus.

Isaiah Nengo, Paul Tafforeau, Christopher C. Gilbert, John G. Fleagle, Ellen R. Miller, Craig Feibel, David L. Fox, Josh Feinberg, Kelsey D. Pugh, Camille Berruyer + et al.

doi: 10.1038/nature23456

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The complete connectome of a learning and memory centre in an insect brain p.175

The complete, synapse-resolution connectome of the Drosophila larval mushroom body.

Katharina Eichler, Feng Li, Ashok Litwin-Kumar, Youngser Park, Ingrid Andrade, Casey M. Schneider-Mizell, Timo Saumweber, Annina Huser, Claire Eschbach, Bertram Gerber + et al.

doi: 10.1038/nature23455

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Letters

No large population of unbound or wide-orbit Jupiter-mass planets p.183

In an analysis of a large sample of microlensing events, a few suggest the existence of Earth-mass free-floating planets, but only the expected number of Jupiter-mass free-floating objects were detected.

Przemek Mróz, Andrzej Udalski, Jan Skowron, Radosław Poleski, Szymon Kozłowski, Michał K. Szymański, Igor Soszyński, Łukasz Wyrzykowski, Paweł Pietrukowicz, Krzysztof Ulaczyk + et al.

doi: 10.1038/nature23276

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Enhanced sensitivity at higher-order exceptional points p.187

The response of a ternary, parity–time-symmetric system that exhibits a third-order exceptional point increases as a function of the cube-root of induced perturbations.

Hossein Hodaei, Absar U. Hassan, Steffen Wittek, Hipolito Garcia-Gracia, Ramy El-Ganainy, Demetrios N. Christodoulides & Mercedeh Khajavikhan

doi: 10.1038/nature23280

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High-temperature crystallization of nanocrystals into three-dimensional superlattices p.197

A bottom-up process to achieve rapid growth of micrometre-sized three-dimensional nanocrystal superlattices during colloidal synthesis at high temperatures is revealed by in situ small-angle X-ray scattering; the process is applicable to several colloidal materials.

Liheng Wu, Joshua J. Willis, Ian Salmon McKay, Benjamin T. Diroll, Jian Qin, Matteo Cargnello & Christopher J. Tassone

doi: 10.1038/nature23308

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Global patterns of drought recovery p.202

A global analysis of gross primary productivity reveals that drought recovery is driven by climate and carbon cycling, with recovery longest in the tropics and high northern latitudes, and with impacts increasing over the twentieth century.

Christopher R. Schwalm, William R. L. Anderegg, Anna M. Michalak, Joshua B. Fisher, Franco Biondi, George Koch, Marcy Litvak, Kiona Ogle, John D. Shaw, Adam Wolf + et al.

doi: 10.1038/nature23021

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Artificial light at night as a new threat to pollination p.206

The pollination service provided by nocturnal flower visitors is disrupted near street lamps, which leads to a reduced reproductive output of the plant that cannot be compensated for by daytime pollinators; in addition, the structure of combined nocturnal and diurnal pollination networks facilitates the spread of the consequences of disrupted night-time pollination to daytime pollinators.

Eva Knop, Leana Zoller, Remo Ryser, Christopher Gerpe, Maurin Hörler & Colin Fontaine

doi: 10.1038/nature23288

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Genetic origins of the Minoans and Mycenaeans p.214

New genome-wide data for ancient, Bronze Age individuals, including Minoans, Mycenaeans, and southwestern Anatolians, show that Minoans and Mycenaeans were genetically very similar yet distinct, supporting the idea of continuity but not isolation in the history of populations of the Aegean.

Iosif Lazaridis, Alissa Mittnik, Nick Patterson, Swapan Mallick, Nadin Rohland, Saskia Pfrengle, Anja Furtwängler, Alexander Peltzer, Cosimo Posth, Andonis Vasilakis + et al.

doi: 10.1038/nature23310

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Prolonged Mek1/2 suppression impairs the developmental potential of embryonic stem cells p.219

Long-term culture of male embryonic stem cells in naive conditions containing Mek1/2 and Gsk3a/b inhibitors leads to irreversible changes in epigenetic and genomic stability that compromise their in vivo developmental potential.

Jiho Choi, Aaron J. Huebner, Kendell Clement, Ryan M. Walsh, Andrej Savol, Kaixuan Lin, Hongcang Gu, Bruno Di Stefano, Justin Brumbaugh, Sang-Yong Kim + et al.

doi: 10.1038/nature23274

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Derivation of ground-state female ES cells maintaining gamete-derived DNA methylation p.224

Derivation of female mouse embryonic stem cells under certain conditions induces a loss of DNA methylation and erasure of genomic imprints, which are not recovered and that may contribute to observed impaired development.

Masaki Yagi, Satoshi Kishigami, Akito Tanaka, Katsunori Semi, Eiji Mizutani, Sayaka Wakayama, Teruhiko Wakayama, Takuya Yamamoto & Yasuhiro Yamada

doi: 10.1038/nature23286

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Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism p.228

Metabolic changes in T cells can affect the genomic methylation status of key transcription factors and regulate the fate decision between induced regulatory T cells and T helper 17 cells.

Tao Xu, Kelly M. Stewart, Xiaohu Wang, Kai Liu, Min Xie, Jae Kyu Ryu, Ke Li, Tianhua Ma, Haixia Wang, Lu Ni + et al.

doi: 10.1038/nature23475

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Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS p.234

Hypoactive BRAF mutants bind more tightly than wild type to the upstream regulator RAS, thus amplifying ERK signalling; tumours expressing these mutants require coexistent mechanisms for RAS activation to grow and are sensitive to their inhibition.

Zhan Yao, Rona Yaeger, Vanessa S. Rodrik-Outmezguine, Anthony Tao, Neilawattie M. Torres, Matthew T. Chang, Matthias Drosten, Huiyong Zhao, Fabiola Cecchi, Todd Hembrough + et al.

doi: 10.1038/nature23291

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A Braf kinase-inactive mutant induces lung adenocarcinoma p.239

Kinase-inactive Braf mutants can initiate the development of lung adenocarcinoma in mice; co-expression of activated Kras enhances tumour initiation and progression, and wild-type Braf is required to sustain tumorigenesis.

Patricia Nieto, Chiara Ambrogio, Laura Esteban-Burgos, Gonzalo Gómez-López, María Teresa Blasco, Zhan Yao, Richard Marais, Neal Rosen, Roberto Chiarle, David G. Pisano + et al.

doi: 10.1038/nature23297

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Proteins evolve on the edge of supramolecular self-assembly p.244

Introducing a single ‘sticky’ (hydrophobic) amino acid by point mutation into symmetric protein complexes frequently triggers their association into higher-order assemblies, without affecting their native fold and structure.

Hector Garcia-Seisdedos, Charly Empereur-Mot, Nadav Elad & Emmanuel D. Levy

doi: 10.1038/nature23320

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