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How fish feel the flow p.406

Hair-like sensors are suspected to aid fish navigation in complex environments. Laboratory experiments and computational simulations reveal how these sensors can detect water flow to direct the swimming responses of fish. See Letter p.445

John O. Dabiri

doi: 10.1038/nature23096

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A new spin on nanoscale computing p.407

A nanoscale magnetic device that mimics the behaviour of neurons has been used to recognize audio signals. Such a device could be adapted to tackle tasks with greater efficiency than conventional computers. See Letter p.428

Frank Hoppensteadt

doi: 10.1038/547407a

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Synapses get together for vision p.408

A sophisticated analysis in mice of how inputs to neurons from other neurons are distributed across individual cells of the brain's visual cortex provides information about how mammalian vision is processed. See Letter p.449

Tobias Rose & Mark Hübener

doi: 10.1038/nature23098

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Molecular structure assignment simplified p.410

An innovative combination of chemical synthesis, theory and spectroscopy could simplify determination of the structures of naturally occurring, biologically active molecules, which are often leads for drug discovery. See Letter p.436a

Severin K. Thompson & Thomas R. Hoye

doi: 10.1038/547410a

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Towards polio eradication p.411

Polio has almost been eradicated. A field study demonstrates that a combination of focused science and epidemiology, and community-based integrated health approaches, are required to finish the job.

Jaime Sepúlveda

doi: 10.1038/547411a

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Articles

In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target p.413

In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 inhibition may potentiate the effect of immunotherapies that invoke an IFNγ response.

Robert T. Manguso, Hans W. Pope, Margaret D. Zimmer, Flavian D. Brown, Kathleen B. Yates, Brian C. Miller, Natalie B. Collins, Kevin Bi, Martin W. LaFleur, Vikram R. Juneja + et al.

doi: 10.1038/nature23270

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Maternal H3K27me3 controls DNA methylation-independent imprinting p.419

Analysis of parental allele-specific chromatin accessibility genome-wide in mouse zygotes and morula embryos, and investigation of the epigenetic mechanisms underlying these allelic sites, identifying maternal H3K27me3 as a DNA methylation-independent mechanism for genomic imprinting.

Azusa Inoue, Lan Jiang, Falong Lu, Tsukasa Suzuki & Yi Zhang

doi: 10.1038/nature23262

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Letters

Significant and variable linear polarization during the prompt optical flash of GRB 160625B p.425

The prompt optical flash produced by the γ-ray burst GRB 160625B is highly linearly polarized, suggesting that it is produced by fast-cooling synchrotron radiation in a large-scale magnetic field.

E. Troja, V. M. Lipunov, C. G. Mundell, N. R. Butler, A. M. Watson, S. Kobayashi, S. B. Cenko, F. E. Marshall, R. Ricci, A. Fruchter + et al.

doi: 10.1038/nature23289

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Neuromorphic computing with nanoscale spintronic oscillators p.428

Spoken-digit recognition using a nanoscale spintronic oscillator that mimics the behaviour of neurons demonstrates the potential of such oscillators for realizing large-scale neural networks in future hardware.

Jacob Torrejon, Mathieu Riou, Flavio Abreu Araujo, Sumito Tsunegi, Guru Khalsa, Damien Querlioz, Paolo Bortolotti, Vincent Cros, Kay Yakushiji, Akio Fukushima + et al.

doi: 10.1038/nature23011

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Synergy of synthesis, computation and NMR reveals correct baulamycin structures p.436

Experimental and computed nuclear magnetic resonance data and an iterative synthetic strategy have revealed the correct structures of the baulamycins, potentially important antimicrobial compounds, allowing them to be chemically synthesized.

Jingjing Wu, Paula Lorenzo, Siying Zhong, Muhammad Ali, Craig P. Butts, Eddie L. Myers & Varinder K. Aggarwal

doi: 10.1038/nature23265

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Global forest loss disproportionately erodes biodiversity in intact landscapes p.441

Deforestation increases the odds of a species being threatened by extinction, and this effect is disproportionately strong in relatively intact landscapes, suggesting that efforts are needed to protect intact forest landscapes and prevent a new wave of extinctions.

Matthew G. Betts, Christopher Wolf, William J. Ripple, Ben Phalan, Kimberley A. Millers, Adam Duarte, Stuart H. M. Butchart & Taal Levi

doi: 10.1038/nature23285

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Synaptic organization of visual space in primary visual cortex p.449

Mapping the organization of excitatory inputs onto the dendritic spines of individual mouse visual cortex neurons reveals how inputs representing features from the extended visual scene are organized and establishes a computational unit suited to amplify contours and elongated edges.

M. Florencia Iacaruso, Ioana T. Gasler & Sonja B. Hofer

doi: 10.1038/nature23019

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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway p.453

Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.

Vasanthi S. Viswanathan, Matthew J. Ryan, Harshil D. Dhruv, Shubhroz Gill, Ossia M. Eichhoff, Brinton Seashore-Ludlow, Samuel D. Kaffenberger, John K. Eaton, Kenichi Shimada, Andrew J. Aguirre + et al.

doi: 10.1038/nature23007

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Cysteine protease cathepsin B mediates radiation-induced bystander effects p.458

The cysteine protease CPR-4, a cathepsin B homologue, is identified as a radiation-induced bystander effect (RIBE) factor in nematodes in response to ultraviolet or ionizing radiation, and causes inhibition of cell death and increased embryonic lethality.

Yu Peng, Man Zhang, Lingjun Zheng, Qian Liang, Hanzeng Li, Jeng-Ting Chen, Hongyan Guo, Sawako Yoshina, Yu-Zen Chen, Xiang Zhao + et al.

doi: 10.1038/nature23284

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Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription p.463

Heterochromatin formation involves histone H3 methylation, with H3K9me2 defining a distinct heterochromatin state that is transcriptionally permissive and can couple with RNAi, and the transition to non-permissive H3K9me3 required for the epigenetic heritability of heterochromatin.

Gloria Jih, Nahid Iglesias, Mark A. Currie, Natarajan V. Bhanu, Joao A. Paulo, Steven P. Gygi, Benjamin A. Garcia & Danesh Moazed

doi: 10.1038/nature23267

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Crystal structures of agonist-bound human cannabinoid receptor CB1 p.468

Crystal structures of the human cannabinoid receptor 1 (CB1) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor activation, and this flexibility may be a common feature among other G-protein-coupled receptors.

Tian Hua, Kiran Vemuri, Spyros P. Nikas, Robert B. Laprairie, Yiran Wu, Lu Qu, Mengchen Pu, Anisha Korde, Shan Jiang, Jo-Hao Ho + et al.

doi: 10.1038/nature23272

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The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture p.472

The lysosomal potassium channel TMEM175 has a tetrameric structure unlike that of the canonical potassium channels, with an hourglass-shaped pore in which isoleucine residues have a key role in channel selectivity.

Changkeun Lee, Jiangtao Guo, Weizhong Zeng, Sunghoon Kim, Ji She, Chunlei Cang, Dejian Ren & Youxing Jiang

doi: 10.1038/nature23269

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