More universities must confront sexual harassment p.379
Too many institutions give low priority to tackling sexual misconduct in science.doi: 10.1038/547379a
Volume 547 Issue 7664
리서치 하이라이트
표지 기사： 제브라피쉬 치어에서 확인된 새로운 기계적 인지 기반 주류성 메커니즘
In vivo CRISPR 스크리닝을 통해 확인된 암 면역치료 타깃, Ptpn2
모계H3K27me3가 조절하는 DNA 메틸화 비의존형 인프린팅
GRB 160625B의 즉각적인 광학적 플래쉬 동안에 심각한 변이적 선형 편광화
구리 산화물 초전도체에서 회전축의 자발적 분해
지방 과산화효소 경로에 의한 암세포의 치료 내성 상태 의존성
시스테인 단백질분해효소 카셉신 B에 의한 방사선 조사의 구경꾼 효과
RNAi 상태 및 유전성 전사 침묵화에 대한 히스톤 H3K9me의 독특한 역할
인간 카나비노이드 수용체 CB1과 작용제 결합 상태에 대한 결정 구조 분석
컨텐츠
Editorials
Put cult online games to the test p.379
There are now vast opportunities to study the effects on young minds.doi: 10.1038/547379b
The digital native is a myth p.380
The younger generation uses technology in the same ways as older people — and is no better at multitasking.doi: 10.1038/547380a
News
Iceland drilling project aims to unearth how islands form p.387
Scientists will look into the heart of Surtsey, an island created 50 years ago by a volcanic eruption.doi: 10.1038/nature.2017.22340
US defence agencies grapple with gene drives p.388
National security community examines the risks and benefits of technology to quickly spread genetic modifications.doi: 10.1038/nature.2017.22345
Brain’s stem cells slow ageing in mice p.389
Transplanted cells offer middle-aged rodents an increased lifespan.doi: 10.1038/547389a
Budding UK innovation agency gains cash — and clout p.390
Business-focused funding agency Innovate UK is driving British efforts to commercialize research.doi: 10.1038/547390a
Giant radio telescope scaled back to contain costs p.391
Crowding antennas closer together may affect the Square Kilometre Array's ability to observe the early Universe.doi: 10.1038/nature.2017.22361
News Features
China’s quest to become a space science superpower p.394
With major spaceflight milestones behind it, China is working to build an international reputation for space science.doi: 10.1038/547394a
News & Views
How fish feel the flow p.406
Hair-like sensors are suspected to aid fish navigation in complex environments. Laboratory experiments and computational simulations reveal how these sensors can detect water flow to direct the swimming responses of fish. See Letter p.445doi: 10.1038/nature23096
A new spin on nanoscale computing p.407
A nanoscale magnetic device that mimics the behaviour of neurons has been used to recognize audio signals. Such a device could be adapted to tackle tasks with greater efficiency than conventional computers. See Letter p.428doi: 10.1038/547407a
Synapses get together for vision p.408
A sophisticated analysis in mice of how inputs to neurons from other neurons are distributed across individual cells of the brain's visual cortex provides information about how mammalian vision is processed. See Letter p.449doi: 10.1038/nature23098
Molecular structure assignment simplified p.410
An innovative combination of chemical synthesis, theory and spectroscopy could simplify determination of the structures of naturally occurring, biologically active molecules, which are often leads for drug discovery. See Letter p.436adoi: 10.1038/547410a
Towards polio eradication p.411
Polio has almost been eradicated. A field study demonstrates that a combination of focused science and epidemiology, and community-based integrated health approaches, are required to finish the job.doi: 10.1038/547411a
Articles
In vivo CRISPR screening identifies Ptpn2 as a cancer immunotherapy target p.413
In vivo CRISPR screening reveals that loss of Ptpn2 increases the response of tumour cells to immunotherapy and increases IFNγ signalling, suggesting that PTPN2 inhibition may potentiate the effect of immunotherapies that invoke an IFNγ response.doi: 10.1038/nature23270
Maternal H3K27me3 controls DNA methylation-independent imprinting p.419
Analysis of parental allele-specific chromatin accessibility genome-wide in mouse zygotes and morula embryos, and investigation of the epigenetic mechanisms underlying these allelic sites, identifying maternal H3K27me3 as a DNA methylation-independent mechanism for genomic imprinting.doi: 10.1038/nature23262
Letters
Significant and variable linear polarization during the prompt optical flash of GRB 160625B p.425
The prompt optical flash produced by the γ-ray burst GRB 160625B is highly linearly polarized, suggesting that it is produced by fast-cooling synchrotron radiation in a large-scale magnetic field.doi: 10.1038/nature23289
Neuromorphic computing with nanoscale spintronic oscillators p.428
Spoken-digit recognition using a nanoscale spintronic oscillator that mimics the behaviour of neurons demonstrates the potential of such oscillators for realizing large-scale neural networks in future hardware.doi: 10.1038/nature23011
Spontaneous breaking of rotational symmetry in copper oxide superconductors p.432
The electronic nematic phase in copper oxide superconductors is found over a broad range of temperature and doping but is not aligned with the crystal axes.doi: 10.1038/nature23290
Synergy of synthesis, computation and NMR reveals correct baulamycin structures p.436
Experimental and computed nuclear magnetic resonance data and an iterative synthetic strategy have revealed the correct structures of the baulamycins, potentially important antimicrobial compounds, allowing them to be chemically synthesized.doi: 10.1038/nature23265
Global forest loss disproportionately erodes biodiversity in intact landscapes p.441
Deforestation increases the odds of a species being threatened by extinction, and this effect is disproportionately strong in relatively intact landscapes, suggesting that efforts are needed to protect intact forest landscapes and prevent a new wave of extinctions.doi: 10.1038/nature23285
A novel mechanism for mechanosensory-based rheotaxis in larval zebrafish p.445
In the absence of visual information, larval zebrafish (Danio rerio) use their mechanosensory lateral line to perform rheotaxis by using flow velocity gradients as navigational cues.doi: 10.1038/nature23014
Synaptic organization of visual space in primary visual cortex p.449
Mapping the organization of excitatory inputs onto the dendritic spines of individual mouse visual cortex neurons reveals how inputs representing features from the extended visual scene are organized and establishes a computational unit suited to amplify contours and elongated edges.doi: 10.1038/nature23019
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway p.453
Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.doi: 10.1038/nature23007
Cysteine protease cathepsin B mediates radiation-induced bystander effects p.458
The cysteine protease CPR-4, a cathepsin B homologue, is identified as a radiation-induced bystander effect (RIBE) factor in nematodes in response to ultraviolet or ionizing radiation, and causes inhibition of cell death and increased embryonic lethality.doi: 10.1038/nature23284
Unique roles for histone H3K9me states in RNAi and heritable silencing of transcription p.463
Heterochromatin formation involves histone H3 methylation, with H3K9me2 defining a distinct heterochromatin state that is transcriptionally permissive and can couple with RNAi, and the transition to non-permissive H3K9me3 required for the epigenetic heritability of heterochromatin.doi: 10.1038/nature23267
Crystal structures of agonist-bound human cannabinoid receptor CB1 p.468
Crystal structures of the human cannabinoid receptor 1 (CB1) bound to the agonists AM11542 and AM841 reveal notable structural rearrangements upon receptor activation, and this flexibility may be a common feature among other G-protein-coupled receptors.doi: 10.1038/nature23272
The lysosomal potassium channel TMEM175 adopts a novel tetrameric architecture p.472
The lysosomal potassium channel TMEM175 has a tetrameric structure unlike that of the canonical potassium channels, with an hourglass-shaped pore in which isoleucine residues have a key role in channel selectivity.doi: 10.1038/nature23269
