Volume 546 Issue 7660

Editorials

News

News Features

News & Views

A larger quantum alphabet p.602

Quantum objects that can hold more information than quantum bits have been generated and manipulated in an integrated photonic platform, paving the way for advanced protocols in quantum information processing. See Letter p.622

doi: 10.1038/546602a

Predictions of virus spillover across species p.603

Most human infectious diseases are initially transmitted from animals. An analysis of all known mammalian viruses improves our understanding of such cross-species spillover, with potential benefits for public health. See Letter p.646

doi: 10.1038/nature23088

A light-fuelled wave machine p.604

A polymer that incorporates liquid-crystal components generates continuous mechanical waves when lit by ultraviolet light, with potential applications for energy harvesting and self-cleaning surfaces. See Letter p.632

doi: 10.1038/546604a

Gut sensor halts viral attack p.606

Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system. See Letter p.667

doi: 10.1038/nature23090

The fingerprints of reaction mechanisms p.608

Small changes to molecular structures can transform how reactions occur, but studying reaction mechanisms directly is difficult. An imaging technique that provides direct insights into competing mechanisms might improve matters.

doi: 10.1038/546608a

Lymphatic detours for cancer p.609

Intestinal infection with rotavirus is a major cause of diarrhoea in infants, and can be fatal. The identification of immune sensor proteins that detect and restrict this viral infection now illuminates the body's defence system. See Letter p.667

doi: 10.1038/546609a

Articles

Structure of a pre-catalytic spliceosome p.617

The cryo-electron microscopy structure of the yeast spliceosome in a pre-catalytic state provides insights into the molecular events leading to formation of the spliceosome active site.

doi: 10.1038/nature22799

Letters

Making waves in a photoactive polymer film p.632

Illumination of thin liquid-crystal polymer films that contain azobenzene derivatives with short thermal relaxation times induces a continuous wave motion throughout the films, owing to a feedback loop driven by material self-shadowing.

doi: 10.1038/nature22987

Hidden morphological diversity among early tetrapods p.642

Detailed micro-computed tomography analysis of the skull of Lethiscus stocki places it much earlier in the tetrapod lineage that was previously thought, showing that early tetrapods were more morphologically diverse than has been believed.

doi: 10.1038/nature22966

Host and viral traits predict zoonotic spillover from mammals p.646

Analysis of a comprehensive database of mammalian host–virus relationships reveals that both the total number of viruses that infect a given species and the proportion likely to be zoonotic are predictable and that this enables identification of mammalian species and geographic locations where novel zoonoses are likely to be found.

doi: 10.1038/nature22975

T cells from patients with Parkinson’s disease recognize α-synuclein peptides p.656

Genetic studies have shown the association of Parkinson’s disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson’s disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson’s disease. These responses may explain the association of Parkinson’s disease with specific major histocompatibility complex alleles.

doi: 10.1038/nature22815