Volume 546 Number 7656

Editorials

Keep shouting to save science p.7

As political leaders on either side of the Atlantic set out contrasting positions on science funding, researchers everywhere need to ensure that their voices are heard.

doi: 10.1038/546007a

News

News Features

News & Views

Signalling under the microscope p.36

G-protein-coupled receptors are biological targets for drug discovery. Developments in cryo-electron microscopy have enabled the solution of the structure of a class B receptor in complex with its signalling protein. Two biologists and a microscopist explain the exciting implications of this work. See Article p.118

doi: 10.1038/nature22491

Multi-molecular views of a stellar nursery p.37

New detectors for radio telescopes can map emissions from many different molecules simultaneously across interstellar clouds. One such pioneering study has probed a wide area of a star-forming cloud in the Orion constellation.

doi: 10.1038/nature22499

An intracellular dance visualized p.39

The development of a microscopy technique that enables observation of the interactions between six types of organelle, in 3D and over time, holds promise for improving our understanding of intracellular processes. See Letter p.162

doi: 10.1038/nature22500

Functional materials at the flick of a switch p.40

The function of materials that have been coated with an ionic liquid can be altered by applying an electric field to shuttle ions in and out. The technique has been used to make materials that have switchable properties. See Letter p.124

doi: 10.1038/546040a

The self-cleansing ability of prehistoric air p.41

Isotopic data from an ice core have been used to estimate atmospheric oxidant levels during past climate transitions — pointing to relatively unexplored climate feedbacks as drivers of atmospheric composition. See Letter p.133

doi: 10.1038/546041a

Diversity breeds tolerance p.44

A gene has been identified that underpins the capacity of mycobacterial cells to divide to produce physiologically different daughter cells. This finding has implications for drug treatment of tuberculosis. See Letter p.153

doi: 10.1038/546044a

Premature lambs grown in a bag p.45

A bag that mimics the environment of the womb can support lambs born extremely prematurely for four weeks. This development points to ways to improve the prospects of extremely premature babies.

doi: 10.1038/546045a

Articles

Ensemble cryo-EM elucidates the mechanism of translation fidelity p.113

Structural ensembles of the 70S ribosome bound to cognate or near-cognate charged tRNAs in complex with EF-Tu illustrate the crucial role of the nucleotide G530 in decoding of mRNA, and demonstrate that translational fidelity results from direct control of GTPase by the decoding centre.

doi: 10.1038/nature22397

Letters