네이처 컨텐츠

Editorials

Keep shouting to save science p.7

As political leaders on either side of the Atlantic set out contrasting positions on science funding, researchers everywhere need to ensure that their voices are heard.

doi: 10.1038/546007a

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News

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Signalling under the microscope p.36

G-protein-coupled receptors are biological targets for drug discovery. Developments in cryo-electron microscopy have enabled the solution of the structure of a class B receptor in complex with its signalling protein. Two biologists and a microscopist explain the exciting implications of this work. See Article p.118

Ching-Ju Tsai, Joerg Standfuss & Robert M. Glaeser

doi: 10.1038/nature22491

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Multi-molecular views of a stellar nursery p.37

New detectors for radio telescopes can map emissions from many different molecules simultaneously across interstellar clouds. One such pioneering study has probed a wide area of a star-forming cloud in the Orion constellation.

Jennifer Wiseman & Marta Sewilo

doi: 10.1038/nature22499

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An intracellular dance visualized p.39

The development of a microscopy technique that enables observation of the interactions between six types of organelle, in 3D and over time, holds promise for improving our understanding of intracellular processes. See Letter p.162

Sang-Hee Shim

doi: 10.1038/nature22500

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Functional materials at the flick of a switch p.40

The function of materials that have been coated with an ionic liquid can be altered by applying an electric field to shuttle ions in and out. The technique has been used to make materials that have switchable properties. See Letter p.124

Shriram Ramanathan

doi: 10.1038/546040a

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The self-cleansing ability of prehistoric air p.41

Isotopic data from an ice core have been used to estimate atmospheric oxidant levels during past climate transitions — pointing to relatively unexplored climate feedbacks as drivers of atmospheric composition. See Letter p.133

Michaela I. Hegglin

doi: 10.1038/546041a

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Diversity breeds tolerance p.44

A gene has been identified that underpins the capacity of mycobacterial cells to divide to produce physiologically different daughter cells. This finding has implications for drug treatment of tuberculosis. See Letter p.153

David G. Russell

doi: 10.1038/546044a

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Premature lambs grown in a bag p.45

A bag that mimics the environment of the womb can support lambs born extremely prematurely for four weeks. This development points to ways to improve the prospects of extremely premature babies.

Claire T. Roberts

doi: 10.1038/546045a

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Articles

Blocking FSH induces thermogenic adipose tissue and reduces body fat p.107

An antibody against the pituitary hormone Fsh reduces adiposity and increases thermogenesis in ovariectomized mice or mice fed a high-fat diet.

Peng Liu, Yaoting Ji, Tony Yuen, Elizabeth Rendina-Ruedy, Victoria E. DeMambro, Samarth Dhawan, Wahid Abu-Amer, Sudeh Izadmehr, Bin Zhou, Andrew C. Shin + et al.

doi: 10.1038/nature22342

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Ensemble cryo-EM elucidates the mechanism of translation fidelity p.113

Structural ensembles of the 70S ribosome bound to cognate or near-cognate charged tRNAs in complex with EF-Tu illustrate the crucial role of the nucleotide G530 in decoding of mRNA, and demonstrate that translational fidelity results from direct control of GTPase by the decoding centre.

Anna B. Loveland, Gabriel Demo, Nikolaus Grigorieff & Andrei A. Korostelev

doi: 10.1038/nature22397

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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex p.118

Volta phase-plate cryo-electron microscopy reveals the structure of the full-length calcitonin receptor in complex with its peptide ligand and Gαsβγ.

Yi-Lynn Liang, Maryam Khoshouei, Mazdak Radjainia, Yan Zhang, Alisa Glukhova, Jeffrey Tarrasch, David M. Thal, Sebastian G. B. Furness, George Christopoulos, Thomas Coudrat + et al.

doi: 10.1038/nature22327

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Letters

Electric-field control of tri-state phase transformation with a selective dual-ion switch p.124

Materials are described here that can change their crystalline phase in response to the electrically controlled insertion or extraction of oxygen and hydrogen ions, giving rise to three distinct phases with different optical, electrical and magnetic properties.

Nianpeng Lu, Pengfei Zhang, Qinghua Zhang, Ruimin Qiao, Qing He, Hao-Bo Li, Yujia Wang, Jingwen Guo, Ding Zhang, Zheng Duan + et al.

doi: 10.1038/nature22389

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Femtosecond response of polyatomic molecules to ultra-intense hard X-rays p.129

Upon exposure to ultra-intense, hard X-ray pulses, polyatomic molecules containing one heavy atom reach a much higher degree of ionization than do individual heavy atoms, contrary to previous assumptions.

A. Rudenko, L. Inhester, K. Hanasaki, X. Li, S. J. Robatjazi, B. Erk, R. Boll, K. Toyota, Y. Hao, O. Vendrell + et al.

doi: 10.1038/nature22373

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Extreme hydrothermal conditions at an active plate-bounding fault p.137

Extreme temperatures and fluid pressures are measured, and their causes modelled, in a borehole into the Alpine Fault, where an earthquake rupture is expected within the next few decades.

Rupert Sutherland, John Townend, Virginia Toy, Phaedra Upton, Jamie Coussens, Michael Allen, Laura-May Baratin, Nicolas Barth, Leeza Becroft, Carolin Boese + et al.

doi: 10.1038/nature22355

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Leaf bacterial diversity mediates plant diversity and ecosystem function relationships p.145

A tree biodiversity and ecosystem function experiment shows that leaf bacterial diversity is positively related to plant community productivity, and explains a portion of the variation in productivity that would otherwise be attributed to plant diversity and functional traits.

Isabelle Laforest-Lapointe, Alain Paquette, Christian Messier & Steven W. Kembel

doi: 10.1038/nature22399

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The sunflower genome provides insights into oil metabolism, flowering and Asterid evolution OPEN p.148

A high-quality reference for the sunflower genome (Helianthus annuus L.) and analysis of gene networks involved in flowering time and oil metabolism provide a basis for nutritional exploitation and analyses of adaptation to climate change.

Hélène Badouin, Jérôme Gouzy, Christopher J. Grassa, Florent Murat, S. Evan Staton, Ludovic Cottret, Christine Lelandais-Brière, Gregory L. Owens, Sébastien Carrère, Baptiste Mayjonade + et al.

doi: 10.1038/nature22380

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Lymphatic endothelial S1P promotes mitochondrial function and survival in naive T cells p.158

The chemoattractant S1P is identified as an extrinsic factor that supports naive T cell survival, and acts via a signalling mechanism to maintain mitochondrial content and function.

Alejandra Mendoza, Victoria Fang, Cynthia Chen, Madhavika Serasinghe, Akanksha Verma, James Muller, V. Sai Chaluvadi, Michael L. Dustin, Timothy Hla, Olivier Elemento + et al.

doi: 10.1038/nature22352

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Applying systems-level spectral imaging and analysis to reveal the organelle interactome p.162

Using confocal and lattice light sheet microscopy, the authors perform systems-level analysis of the organelle interactome in live cells, allowing them to visualize the frequency and locality of up to five-way interactions between different organelles.

Alex M. Valm, Sarah Cohen, Wesley R. Legant, Justin Melunis, Uri Hershberg, Eric Wait, Andrew R. Cohen, Michael W. Davidson, Eric Betzig & Jennifer Lippincott-Schwartz

doi: 10.1038/nature22369

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CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells p.168

In human cell lines with mutant KRAS and loss of LKB1, CPS1 expression correlates inversely with LKB1 expression; silencing CPS1 in these cells induces DNA damage and cell death as a result of pyrimidine depletion rather than ammonia toxicity.

Jiyeon Kim, Zeping Hu, Ling Cai, Kailong Li, Eunhee Choi, Brandon Faubert, Divya Bezwada, Jaime Rodriguez-Canales, Pamela Villalobos, Yu-Fen Lin + et al.

doi: 10.1038/nature22359

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