Liquid-biopsies success highlights power of combining basic and clinical research p.393
Using free-floating DNA to detect lung cancer brings benefits to researchers and patients alike.doi: 10.1038/544393a
Volume 544 Issue 7651
Editorials
More surgeons must start doing basic science p.393
They say they don't have the time or incentives to do research — and that’s dangerous for translational medicine.doi: 10.1038/544393b
Announcement: Nature journals support the San Francisco Declaration on Research Assessment p.394
doi: 10.1038/nature.2017.21882
News
California’s $3-billion bet on stem cells faces final test p.401
Major investment in regenerative medicine enters its last stage — and the money might run out before treatments are ready.doi: 10.1038/544401a
Ripple effects of New Zealand earthquake continue to this day p.402
November tremor sparked slow, deep movements in Earth’s crust that increase the chances of a similar severe quake within a year.doi: 10.1038/nature.2017.21876
Mining threatens Chinese fossil site that revealed planet's earliest animals p.403
Protests sparked by the destruction of three key fossil-hunting areas result in a temporary halt of phosphate mining.doi: 10.1038/nature.2017.21869
What happened at March for Science events around the world p.404
Nature reported from marches in cities including Sydney, Washington DC and Paris, as people took to the streets in support of science.doi: 10.1038/nature.2017.21853
Surprise El Niño causes devastation but offers lessons for ecologists p.405
How Peruvian coastal deserts respond to rains will aid future disaster response.doi: 10.1038/544405a
News Features
The next big hit in molecule Hollywood p.408
Superfast imaging techniques are giving researchers their best views yet of what happens in the atomic world.doi: 10.1038/544408a
News & Views
How to build a better dad p.418
Oldfield mice and deer mice differ in their parental care, most dramatically in the behaviour of fathers. A study reveals the genetic and neuronal contributions to variation in parental care. See Article p.434doi: 10.1038/nature22486
Strangeness in the proton p.419
The proton can contain pairs of elementary particles known as strange quarks. The contribution of these particles to the proton's electric-charge distribution and magnetic moment has been determined.doi: 10.1038/nature21909
Unexpectedly early signs of Americans p.420
Humans are thought to have reached the Americas less than 15,000 years ago. But evidence of stone tool use on an animal carcass excavated in California points to a much earlier arrival of human relatives from the genus Homo. See Letter p.479doi: 10.1038/544420a
Severe weather in a warming climate p.422
During the past few decades, the Sahara Desert has become even hotter. Satellite observations suggest that this warming has led to a rise in the frequency of extreme storms in the Sahel region of West Africa. See Letter p.475doi: 10.1038/544422a
A larger palette for biological imaging p.423
Biological molecules are often imaged by attaching fluorescent labels — but only a few label types can be used at a time. A method that could smash the record for the number of labels that can be used together is now reported. See Letter p.465doi: 10.1038/544423a
Genomic compartments in barley p.424
A high-quality barley genome reveals a surprising compartmentalization of genes and repetitive sequences in chromosomes. This advance paves the way for improved genetic optimization of cereals. See Article p.427doi: 10.1038/544424a
Articles
A chromosome conformation capture ordered sequence of the barley genome OPEN p.427
The International Barley Genome Sequencing Consortium reports sequencing and assembly of a reference genome for barley, Hordeum vulgare.doi: 10.1038/nature22043
The genetic basis of parental care evolution in monogamous mice p.434
Parental care in mice evolves through multiple genetic changes; one candidate is vasopressin, the reduced expression of which promotes parental nest-building behaviour in monogamous mice.doi: 10.1038/nature22074
Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure p.440
The cryo-electron microscopy structure of Saccharomyces cerevisiae Snf2 chromatin remodeller bound to a nucleosome and a proposed mechanism for DNA translocation by Snf2 are presented.doi: 10.1038/nature22036
Structure and allosteric inhibition of excitatory amino acid transporter 1 p.446
High-resolution structures of the thermostabilized human excitatory amino acid transporter EAAT1, alone or in association with its substrate or small molecule inhibitors, reveal architectural features of human SLC1 transporters and an allosteric mechanism of inhibition.doi: 10.1038/nature22064
Letters
A universal model for solar eruptions p.452
Simulations of a solar coronal jet driven by filament ejection demonstrate that magnetic reconnection underlies the energy release, implying that a universal ‘breakout’ model explains both tiny jets and huge mass ejections from the Sun.doi: 10.1038/nature22050
Predicting crystal growth via a unified kinetic three-dimensional partition model p.456
A general simulation approach that can replicate, and in theory predict, the growth of a wide range of crystal types, including porous, molecular and ionic crystals, is demonstrated.doi: 10.1038/nature21684
Ultrastrong steel via minimal lattice misfit and high-density nanoprecipitation p.460
A method of producing superstrong yet ductile steels using cheaper and lighter alloying elements is described, based on minimization of the lattice misfit to achieve a maximal dispersion of nanoprecipitates, leading to ultimate precipitation strengthening.doi: 10.1038/nature22032
Super-multiplex vibrational imaging p.465
Stimulated Raman scattering under electronic pre-resonance conditions, combined with a new palette of probes, enables super-multiplex imaging of molecular targets in living cells with very high vibrational selectivity and sensitivity.doi: 10.1038/nature22051
Abrasion-set limits on Himalayan gravel flux p.471
The amount of coarse gravel transported out of the Himalayan mountains by rivers is insensitive to catchment size, because the majority of gravel sourced more than 100 kilometres upstream of the mountain front is abraded into sand before it reaches the Ganga Plain.doi: 10.1038/nature22039
Frequency of extreme Sahelian storms tripled since 1982 in satellite observations p.475
Since 1982, extreme daily rainfall in the western Sahel has increased persistently, owing to a warmer Sahara which has led to increased wind shear and an increase in intense storms.doi: 10.1038/nature22069
A 130,000-year-old archaeological site in southern California, USA p.479
Evidence of mastodon bone modifications for marrow extraction and/or tool production, found in the presence of hammerstones and anvils that showed use-wear and impact marks, suggest the presence of Homo in North America around 130 thousand years ago.doi: 10.1038/nature22065
The earliest bird-line archosaurs and the assembly of the dinosaur body plan p.484
The archosaur species Teleocrater rhadinus, part of the new clade Aphanosauria, is an example of the earliest divergence of the avian stem lineage (Avemetatarsalia), the lineage that contains dinosaurs (including birds).doi: 10.1038/nature22037
Human umbilical cord plasma proteins revitalize hippocampal function in aged mice p.488
Treatment with plasma of an early developmental stage, human umbilical cord, revitalizes the hippocampus and improves cognitive function in aged mice.doi: 10.1038/nature22067
SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin p.493
The identification of homotypic SLAMF7 interactions responsible for haematopoietic tumour cell phagocytosis by macrophages when the inhibitory receptor/ligand interaction of SIRPα/CD47 is blocked therapeutically.doi: 10.1038/nature22076
High-avidity IgA protects the intestine by enchaining growing bacteria p.498
doi: 10.1038/nature22058
Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl p.503
The distribution of cohesin in the mouse genome depends on CTCF, transcription and the cohesin release factor Wapl.doi: 10.1038/nature22063
