네이처 컨텐츠

Editorials

Nature supports the March for Science p.137

Critics of the March for Science have a point. But those scientists who will protest and speak up globally for research have the chance to make a greater one.

doi: 10.1038/544137a

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News

Fish live longer on ‘young poo’ p.147

The gut microbes of young killifish can extend the lifespans of older fish – hinting at the microbiome’s role in ageing.

Ewen Callaway

doi: 10.1038/nature.2017.21770

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News Features

News & Views

Liquid crystals in living tissue p.164

Evidence has been found that a biological tissue might behave like a liquid crystal. Even more remarkably, topological defects in this liquid-crystal system seem to influence cell behaviour. A materials physicist and a biologist discuss what the findings mean for researchers in their fields. See Letter p.212

Linda S. Hirst & Guillaume Charras

doi: 10.1038/544164a

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The race to fish slows down p.165

A fishery can allow participants to fish as hard as they can until its quota is reached, or allocate quota shares that can be caught at any time. A comparison of the systems in action reveals that shares slow the race to fish. See Letter p.223

Andrew A. Rosenberg

doi: 10.1038/nature21906

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Screen printing of 2D semiconductors p.167

Atomically thin semiconductors have been made by transferring the oxide 'skin' of a liquid metal to substrates. This opens the way to the low-cost mass production of 2D semiconductors at the sizes needed for electronics applications.

Young Duck Kim & James Hone

doi: 10.1038/nature21908

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Crown-of-thorns no more p.168

The starfish Acanthaster planci destroys coral reefs. Whole- genome sequences provide clues to the proteins that mediate A. planci outbreaks — information that might be used to help protect coral. See Letter p.231

Mónica Medina

doi: 10.1038/nature21905

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How the lizard gets its speckled scales p.170

Can a reptile compute? In one species of lizard, Timon lepidus, the colour and pattern of its scales evolve in a manner akin to a discrete rule-based computation called a cellular automaton. See Letter p.173

Leah Edelstein-Keshet

doi: 10.1038/544170a

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Human genes lost and their functions found p.171

Individuals who lack a functional copy of a gene — gene knockouts — can reveal the gene's role. Most knockout research has used model organisms, but now a comprehensive catalogue of human knockouts is in sight. See Letter p.235

Robert M. Plenge

doi: 10.1038/544171a

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Articles

A living mesoscopic cellular automaton made of skin scales p.173

A mesoscopic cellular automaton arising from a microscopic reaction–diffusion system as a function of skin thickness is observed in ocellated lizards, showing that cellular automata are not merely abstract computational systems, but can directly correspond to processes generated by biological evolution.

Liana Manukyan, Sophie A. Montandon, Anamarija Fofonjka, Stanislav Smirnov & Michel C. Milinkovitch

doi: 10.1038/nature22031

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Mediator structure and rearrangements required for holoenzyme formation p.196

Cryo-electron microscopy maps of the fission yeast Mediator complex and of a Mediator–RNA polymerase II holoenzyme reveal how changes in the Med14 subunit enable large-scale rearrangements of the Mediator structure that are essential for holoenzyme formation.

Kuang-Lei Tsai, Xiaodi Yu, Sneha Gopalan, Ti-Chun Chao, Ying Zhang, Laurence Florens, Michael P. Washburn, Kenji Murakami, Ronald C. Conaway, Joan W. Conaway + et al.

doi: 10.1038/nature21393

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Letters

Star formation inside a galactic outflow p.202

Star formation at a rate of more than 15 solar masses a year has been observed inside a massive outflow of gas from a nearby galaxy; this could also be happening inside other galactic outflows.

R. Maiolino, H. R. Russell, A. C. Fabian, S. Carniani, R. Gallagher, S. Cazzoli, S. Arribas, F. Belfiore, E. Bellocchi, L. Colina + et al.

doi: 10.1038/nature21677

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Optically excited structural transition in atomic wires on surfaces at the quantum limit p.207

A structural transition in an atomic indium wire on a silicon substrate proceeds as fast as the indium atom vibrations and is facilitated by strong In–Si interface bonds.

T. Frigge, B. Hafke, T. Witte, B. Krenzer, C. Streubühr, A. Samad Syed, V. Mikšić Trontl, I. Avigo, P. Zhou, M. Ligges + et al.

doi: 10.1038/nature21432

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Topological defects in epithelia govern cell death and extrusion p.212

By modelling epithelial cells as active nematic liquid crystals, stresses induced at the sites of topological defects are found to be the primary drivers of extrusion and cell death.

Thuan Beng Saw, Amin Doostmohammadi, Vincent Nier, Leyla Kocgozlu, Sumesh Thampi, Yusuke Toyama, Philippe Marcq, Chwee Teck Lim, Julia M. Yeomans & Benoit Ladoux

doi: 10.1038/nature21718

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Catch shares slow the race to fish p.223

A large-scale treatment–control meta-analysis of US fisheries provides evidence that the implementation of catch shares extend fishing seasons by slowing the race to fish.

Anna M. Birkenbach, David J. Kaczan & Martin D. Smith

doi: 10.1038/nature21728

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Evolutionary dynamics on any population structure p.227

The authors derive a condition for how natural selection chooses between two competing strategies on any graph for weak selection, elucidating which population structures promote certain behaviours, such as cooperation.

Benjamin Allen, Gabor Lippner, Yu-Ting Chen, Babak Fotouhi, Naghmeh Momeni, Shing-Tung Yau & Martin A. Nowak

doi: 10.1038/nature21723

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The crown-of-thorns starfish genome as a guide for biocontrol of this coral reef pest OPEN p.231

Genome sequencing and proteomic analyses of the crown-of-thorns starfish identify species-specific secreted factors that are associated with aggregating starfish and might be useful for biocontrol strategies.

Michael R. Hall, Kevin M. Kocot, Kenneth W. Baughman, Selene L. Fernandez-Valverde, Marie E. A. Gauthier, William L. Hatleberg, Arunkumar Krishnan, Carmel McDougall, Cherie A. Motti, Eiichi Shoguchi + et al.

doi: 10.1038/nature22033

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Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity p.235

By sequencing the exomes of 10,503 individuals living in Pakistan, the authors identify rare predicted loss-of-function mutations that are estimated to knock out genes and correlate these mutations with a broad range of phenotypes, providing a framework for a human knockout project.

Danish Saleheen, Pradeep Natarajan, Irina M. Armean, Wei Zhao, Asif Rasheed, Sumeet A. Khetarpal, Hong-Hee Won, Konrad J. Karczewski, Anne H. O’Donnell-Luria, Kaitlin E. Samocha + et al.

doi: 10.1038/nature22034

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Re-evaluation of learned information in Drosophila p.240

Depending on prediction accuracy at the time of memory recall, specific mushroom body output neurons drive different combinations of dopaminergic neurons to extinguish or reconsolidate appetitive memory in Drosophila.

Johannes Felsenberg, Oliver Barnstedt, Paola Cognigni, Suewei Lin & Scott Waddell

doi: 10.1038/nature21716

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Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates p.245

The neuron-specific transcription factor Myt1l represses many somatic lineage programs, but not the neuronal lineage program, to both induce and maintain neuronal identity.

Moritz Mall, Michael S. Kareta, Soham Chanda, Henrik Ahlenius, Nicholas Perotti, Bo Zhou, Sarah D. Grieder, Xuecai Ge, Sienna Drake, Cheen Euong Ang + et al.

doi: 10.1038/nature21722

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Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming p.250

The cross-talk between immune cells and blood vessel endothelial cells promotes pericyte coverage and decreases hypoxia in mouse tumour models, and correlative evidence suggests that these processes influence cancer prognosis in humans.

Lin Tian, Amit Goldstein, Hai Wang, Hin Ching Lo, Ik Sun Kim, Thomas Welte, Kuanwei Sheng, Lacey E. Dobrolecki, Xiaomei Zhang, Nagireddy Putluri + et al.

doi: 10.1038/nature21724

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