네이처 컨텐츠

Editorials

News

How Brexit is changing the lives of eight researchers p.600

The months between the Brexit vote and this week's triggering of Article 50 have been a turbulent time for scientists — and things show no sign of calming.

Alison Abbott, Ewen Callaway, Daniel Cressey, Elizabeth Gibney & Inga Vesper

doi: 10.1038/nature.2017.21714

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News Features

News & Views

Tumour stem-cell surprises p.626

Stem-cell divisions are thought to be essential to tumour growth. Targeted removal of a specific stem-cell population reveals its role in tumour development and in the growth of tumours formed by cell migration to distant sites. See Article p.676

Florian R. Greten

doi: 10.1038/543626a

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Making iron glow p.627

An iron complex has been made that has a long-lived excited state and emits light at room temperature as a result of a charge-transfer process. This breakthrough might allow the production of cheap solar cells. See Letter p.695

Felix N. Castellano

doi: 10.1038/543627a

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Forty years of cellular clues from worms p.628

The cell divisions that occur when a larva develops into an adult Caenorhabditis elegans worm were described in a cell-lineage map in 1977. The work has provided the foundation for many discoveries about developmental mechanisms.

Paul W. Sternberg

doi: 10.1038/543628a

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How to heal an ocean p.630

Marine protected areas are being implemented at an accelerating pace, and hold promise for restoring damaged ecosystems. But glaring shortfalls in staffing and funding often lead to suboptimal outcomes. See Article p.665

Boris Worm

doi: 10.1038/nature21895

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Auditory landscape on the cognitive map p.631

Subpopulations of neurons fire at specific geographical locations, providing a mental map of an animal's position in space. The finding that the circuitry can also support auditory maps sheds light on the neuronal structure of cognition. See Letter p.719

Jon W. Rueckemann & Elizabeth A. Buffalo

doi: 10.1038/543631a

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Eating ourselves dry p.633

Do human consumption habits affect groundwater depletion as a result of international food trade? A global analysis indicates that they do, and shows which products and countries have the biggest impact. See Letter p.700

Maite M. Aldaya

doi: 10.1038/543633a

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The leukaemia epigenome targeted p.634

Modification of methyl groups attached to DNA alters gene expression, and mutations that deregulate this methylation are common in some leukaemias. Drugs that target aberrant methylation are emerging as promising therapeutics.

Julie-Aurore Losman

doi: 10.1038/543634a

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Reckless orbiting in the Solar System p.635

Planets and most asteroids revolve around the Sun in the same direction. But an asteroid that shares Jupiter's orbit has been revolving in the opposite direction for about a million years. See Letter p.687

Helena Morais & Fathi Namouni

doi: 10.1038/543635a

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Reviews

Articles

Functional materials discovery using energy–structure–function maps p.657

Energy–structure–function maps that describe the possible structures and properties of molecular crystals are developed, and these maps are used to guide the experimental discovery of porous materials with specific functions.

Angeles Pulido, Linjiang Chen, Tomasz Kaczorowski, Daniel Holden, Marc A. Little, Samantha Y. Chong, Benjamin J. Slater, David P. McMahon, Baltasar Bonillo, Chloe J. Stackhouse + et al.

doi: 10.1038/nature21419

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Capacity shortfalls hinder the performance of marine protected areas globally p.665

Although 71% of marine protected areas are benefiting fish populations, their effects are highly variable, with staff capacity proving to be the most important explanatory variable.

David A. Gill, Michael B. Mascia, Gabby N. Ahmadia, Louise Glew, Sarah E. Lester, Megan Barnes, Ian Craigie, Emily S. Darling, Christopher M. Free, Jonas Geldmann + et al.

doi: 10.1038/nature21708

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Neural ensemble dynamics underlying a long-term associative memory p.670

Use of a head-mounted miniature microscope in awake, behaving mice reveals that neural ensembles in the basal and lateral amygdala encode associations between conditioned and unconditioned stimuli in a way that matches models of supervised learning.

Benjamin F. Grewe, Jan Gründemann, Lacey J. Kitch, Jerome A. Lecoq, Jones G. Parker, Jesse D. Marshall, Margaret C. Larkin, Pablo E. Jercog, Francois Grenier, Jin Zhong Li + et al.

doi: 10.1038/nature21682

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A distinct role for Lgr5+ stem cells in primary and metastatic colon cancer p.676

Ablation of Lgr5+ cancer stem cells does not result in regression of primary colorectal tumours, but prevents the formation and maintenance of metastasis in the liver.

Felipe de Sousa e Melo, Antonina V. Kurtova, Jonathan M. Harnoss, Noelyn Kljavin, Joerg D. Hoeck, Jeffrey Hung, Jeffrey Eastham Anderson, Elaine E. Storm, Zora Modrusan, Hartmut Koeppen + et al.

doi: 10.1038/nature21713

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LACTB is a tumour suppressor that modulates lipid metabolism and cell state p.681

LACTB modulates mitochondrial lipid metabolism and changes the differentiation state of breast cancer cells, thereby negatively affecting the growth of various tumorigenic, but not non-tumorigenic, cells both in vitro and in vivo.

Zuzana Keckesova, Joana Liu Donaher, Jasmine De Cock, Elizaveta Freinkman, Susanne Lingrell, Daniel A. Bachovchin, Brian Bierie, Verena Tischler, Aurelia Noske, Marian C. Okondo + et al.

doi: 10.1038/nature21408

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Letters

A retrograde co-orbital asteroid of Jupiter p.687

Asteroid 2015 BZ509 is a retrograde co-orbital asteroid of the planet Jupiter, stably orbiting in a sense opposite to that of Jupiter’s orbit around the Sun for around a million years.

Paul Wiegert, Martin Connors & Christian Veillet

doi: 10.1038/nature22029

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Ultra-selective high-flux membranes from directly synthesized zeolite nanosheets p.690

A direct synthesis of high-aspect-ratio microporous zeolite nanosheets and the use of such nanosheets in separation membranes are described.

Mi Young Jeon, Donghun Kim, Prashant Kumar, Pyung Soo Lee, Neel Rangnekar, Peng Bai, Meera Shete, Bahman Elyassi, Han Seung Lee, Katabathini Narasimharao + et al.

doi: 10.1038/nature21421

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A low-spin Fe(iii) complex with 100-ps ligand-to-metal charge transfer photoluminescence p.695

Transition-metal complexes are used as photosensitizers, in light-emitting diodes, for biosensing and in photocatalysis. A key feature in these applications is excitation from the ground state to a charge-transfer state; the long charge-transfer-state lifetimes typical for complexes of ruthenium and other precious metals are often essential to ensure high performance. There is much interest in replacing these scarce elements with Earth-abundant metals, with iron and copper being particularly attractive owing to their low cost and non-toxicity. But despite the exploration of innovative molecular designs, it remains a formidable scientific challenge to access Earth-abundant transition-metal complexes with long-lived charge-transfer excited states. No known iron complexes are considered photoluminescent at room temperature, and their rapid excited-state deactivation precludes their use as photosensitizers. Here we present the iron complex [Fe(btz)3]3+ (where btz is 3,3′-dimethyl-1,1′-bis(p-tolyl)-4,4′-bis(1,2,3-triazol-5-ylidene)), and show that the superior σ-donor and π-acceptor electron properties of the ligand stabilize the excited state sufficiently to realize a long charge-transfer lifetime of 100 picoseconds (ps) and room-temperature photoluminescence. This species is a low-spin Fe(iii) d5 complex, and emission occurs from a long-lived doublet ligand-to-metal charge-transfer (2LMCT) state that is rarely seen for transition-metal complexes. The absence of intersystem crossing, which often gives rise to large excited-state energy losses in transition-metal complexes, enables the observation of spin-allowed emission directly to the ground state and could be exploited as an increased driving force in photochemical reactions on surfaces. These findings suggest that appropriate design strategies can deliver new iron-based materials for use as light emitters and photosensitizers.

Pavel Chábera, Yizhu Liu, Om Prakash, Erling Thyrhaug, Amal El Nahhas, Alireza Honarfar, Sofia Essén, Lisa A. Fredin, Tobias C. B. Harlang, Kasper S. Kjær + et al.

doi: 10.1038/nature21430

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Groundwater depletion embedded in international food trade p.700

Global food consumption drives irrigation for crops, which depletes aquifers in some regions; here we quantify the volumes of groundwater depletion associated with global food production and international trade.

Carole Dalin, Yoshihide Wada, Thomas Kastner & Michael J. Puma

doi: 10.1038/nature21403

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Transboundary health impacts of transported global air pollution and international trade p.705

The transboundary health impacts of air pollution associated with the international trade of goods and services are greater than those associated with long-distance atmospheric pollutant transport.

Qiang Zhang, Xujia Jiang, Dan Tong, Steven J. Davis, Hongyan Zhao, Guannan Geng, Tong Feng, Bo Zheng, Zifeng Lu, David G. Streets + et al.

doi: 10.1038/nature21712

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Somatic mutations reveal asymmetric cellular dynamics in the early human embryo p.714

Whole-genome sequencing of normal blood cells sampled from 241 adults is used to infer mosaic point mutations that are likely to have arisen during early embryogenesis, providing insight into how early cellular dynamics may affect adult tissues.

Young Seok Ju, Inigo Martincorena, Moritz Gerstung, Mia Petljak, Ludmil B. Alexandrov, Raheleh Rahbari, David C. Wedge, Helen R. Davies, Manasa Ramakrishna, Anthony Fullam + et al.

doi: 10.1038/nature21703

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Antigen presentation profiling reveals recognition of lymphoma immunoglobulin neoantigens p.723

Evidence for the abundant presentation of class II neoantigens by a human B-cell lymphoma.

Michael S. Khodadoust, Niclas Olsson, Lisa E. Wagar, Ole A. W. Haabeth, Binbin Chen, Kavya Swaminathan, Keith Rawson, Chih Long Liu, David Steiner, Peder Lund + et al.

doi: 10.1038/nature21433

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Effective combinatorial immunotherapy for castration-resistant prostate cancer p.728

A new chimaeric mouse model of metastatic castration-resistant prostate cancer to efficiently test combination therapies in an autochthonous setting.

Xin Lu, James W. Horner, Erin Paul, Xiaoying Shang, Patricia Troncoso, Pingna Deng, Shan Jiang, Qing Chang, Denise J. Spring, Padmanee Sharma + et al.

doi: 10.1038/nature21676

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The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1 p.733

The selective allosteric ABL1 inhibitor ABL001 (asciminib) represents a new inhibitory mechanism for BCR–ABL1-driven malignancies, and its efficacy and evolving mechanisms of resistance do not overlap with those of other BCR–ABL1 kinase inhibitors.

Andrew A. Wylie, Joseph Schoepfer, Wolfgang Jahnke, Sandra W. Cowan-Jacob, Alice Loo, Pascal Furet, Andreas L. Marzinzik, Xavier Pelle, Jerry Donovan, Wenjing Zhu + et al.

doi: 10.1038/nature21702

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Energy transduction and alternating access of the mammalian ABC transporter P-glycoprotein p.738

Double electron–electron resonance and computer simulations are used to describe conformational dynamics in the ATP-binding cassette transporter Pgp, which has an important role in the clearance of xenobiotics and cancer resistance to chemotherapy.

Brandy Verhalen, Reza Dastvan, Sundarapandian Thangapandian, Yelena Peskova, Hanane A. Koteiche, Robert K. Nakamoto, Emad Tajkhorshid & Hassane S. Mchaourab

doi: 10.1038/nature21414

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