Volume 543 Number 7643

Editorials

News

News Features

Human migration p.21

A special issue explores the intersection of science and migration.

doi: 10.1038/543021a

News & Views

Lessons from tooth enamel p.42

A remarkable composite material has been made that mimics the structure of tooth enamel. This achievement opens up the exploration of new composite materials and of computational methods that reliably predict their properties. See Letter p.95

doi: 10.1038/543042a

Stretched divisions p.43

Many organ surfaces are covered by a protective epithelial-cell layer. It emerges that such layers are maintained by cell stretching that triggers cell division mediated by the force-sensitive ion-channel protein Piezo1. See Letter p.118

doi: 10.1038/nature21502

Subduction undone p.44

Rocks are subjected to increased pressure as they are buried during subduction. Contrary to general belief, a study suggests that peak pressures recorded in subducted rocks might not reflect their maximum burial depths.

doi: 10.1038/543044a

Commonality with cancer p.45

Ageing is associated with an increased risk of cardiovascular disease caused by the rupture of inflamed cholesterol plaques in arteries. It emerges that this might be partly due to genetic mutations that cause cancerous changes in white blood cells.

doi: 10.1038/nature21505

A solid more fluid than a fluid p.47

A supersolid is a paradoxical and elusive state of matter that has been sought for more than 60 years. Two experiments have now observed its characteristic signatures in ultracold quantum matter. See Letters p.87 & p.91

doi: 10.1038/543047a

T-cell tweaks to target tumours p.48

Immune cells known as T cells can destroy tumour cells, but their clinical use requires complex preparation and the cells can lose effectiveness over time. A new approach might improve the efficiency of T-cell therapy. See Letter p.113

doi: 10.1038/nature21506

Origin of a key player in methane biosynthesis p.49

The biosynthesis of a coenzyme in the microbial production of methane has been determined — completing the biosynthetic pathways for the family of compounds that includes chlorophyll, haem and vitamin B12. See Article p.78

doi: 10.1038/nature21507

Review

Articles

Whole-genome landscape of pancreatic neuroendocrine tumours p.65

The genomes of 102 primary pancreatic neuroendocrine tumours have been sequenced, revealing mutations in genes with functions such as chromatin remodelling, DNA damage repair, mTOR activation and telomere maintenance, and a greater-than-expected contribution from germ line mutations.

doi: 10.1038/nature21063

Letters

Abiotic tooth enamel p.95

Nanometre-scale columnar structures in tooth enamel inspire novel nanocomposites containing layers of vertically aligned nanowires, produced by layer-by-layer fabrication and combining high values of both storage modulus and energy dissipation.

doi: 10.1038/nature21410