President Trump’s unconventional stances cannot go unchallenged.
The latest update on Nature’s sexism shows an increase in female contributors and referees since 2012, but there is a long way to go.
Preparation against future epidemic threats is a welcome and essential move.
The US president reiterated his promise to roll back climate regulations on his first day in office.
Massive effort plans to stockpile vaccines against future outbreaks.
Old-school areas of plant biology are getting tech upgrades that herald more detailed, faster data collection.
Open-science advocate says journals should be clearer to peer-reviewers about terms and conditions.
What Novozymes might do with the NgAgo protein, claimed by some to be a powerful gene editor, is still unclear.
Scepticism surrounds the ultimate potential of D-wave machines, but researchers are already finding uses for them.
US agency releases finalized ‘Common Rule’, which governs human-subjects research.
Moonshots, road maps, frameworks and more are proliferating, but few can agree on what these names even mean.
News & Views
It emerges that phage viruses, which infect bacteria, use small peptides to communicate with each other. This observation of intercellular communication also reveals how viruses make a key developmental decision. See Article p.488
Precise measurements of antimatter systems might cast light on why the Universe is dominated by matter. The observation of a transition in an antihydrogen atom heralds the next wave of high-precision antimatter studies. See Letter p.506
Earth grew by the accretion of meteoritic material. High-precision isotopic data reveal how the composition of this material changed over time, forcing revision of models of our planet's formation. See Letters p.521 & p.525
Materials called hydrogels have potential applications as scaffolds for tissue engineering, but methods are needed to assemble them into complex structures that mimic those found in nature. Just such a method has now been reported.
Translation of RNA into proteins is a fundamental process for all cells. Analysis of a mouse model of skin cancer uncovers an atypical RNA-translation program that has a vital role in tumour formation. See Article p.494
A reactive astrocyte subtype termed A1 is induced after injury or disease of the central nervous system and subsequently promotes the death of neurons and oligodendrocytes.
Some phages—viruses that infect bacteria—encode peptides that are secreted from infected cells and that, beyond a certain threshold, stimulate other viruses to switch from the lytic (killing the host cell) to lysogenic (dormant) phase.
The translation of upstream open reading frames in skin tumour models protects some cancer-related mRNAs from global reductions in protein synthesis during the early stages of tumour initiation, suggesting that unconventional translation has a crucial role in tumorigenesis.
Some CLC proteins are channels that conduct chloride ions passively, whereas others are active co-transporters, a difference that has been hard to understand given their high degree of sequence homology; now, cryo-electron microscopy is used to determine the structure of a mammalian CLC channel, shedding light on this question.
The 1S–2S transition in magnetically trapped atoms of antihydrogen is observed, and its frequency is shown to be consistent with that expected for hydrogen.
The chemical conversion of N-heterocyclic carbene molecules attached to catalytic particles is monitored at high spatial resolution using synchrotron-radiation-based infrared nanospectroscopy.
A study of how temperature and water availability fluctuations affect the carbon balance of land ecosystems reveals different controls on local and global scales, implying that spatial climate covariation drives the global carbon cycle response.
The mantle signatures of elements with distinct affinities for metal isotopically record different stages of Earth’s accretion, revealing that the Moon-forming impactor had a similar composition to the other impactors that made the Earth.
All chondrites are shown to have Ru isotopic compositions that are more different from that of the Earth’s mantle the further from the Sun they formed; this means the Earth’s late veneer cannot derive from volatile-rich material formed in the outer Solar System.
Nomadic movement across the breeding range enables male pectoral sandpipers to display and sire offspring at multiple sites within a single breeding season, with tenure depending on breeding female numbers at each site.
The wisdom of the crowd can be improved by using an algorithm that selects the answer that is more popular than people predict, rather than the answer that is most popular.
The genome of the Southern Ocean phytoplankton Fragilariopsis cylindrus differs markedly from the genomes of its more temperate relatives, with divergent alleles being differentially expressed in environmentally specific conditions such as freezing and darkness.
Cell fate perturbations underlie many human diseases, including breast cancer. Unfortunately, the mechanisms by which breast cell fate are regulated are largely unknown. The mammary gland epithelium consists of differentiated luminal epithelial and basal myoepithelial cells, as well as undifferentiated stem cells and more restricted progenitors. Breast cancer originates from this epithelium, but the molecular mechanisms that underlie breast epithelial hierarchy remain ill-defined. Here, we use a high-content confocal image-based short hairpin RNA screen to identify tumour suppressors that regulate breast cell fate in primary human breast epithelial cells. We show that ablation of the large tumour suppressor kinases (LATS) 1 and 2 (refs 5, 6), which are part of the Hippo pathway, promotes the luminal phenotype and increases the number of bipotent and luminal progenitors, the proposed cells-of-origin of most human breast cancers. Mechanistically, we have identified a direct interaction between Hippo and oestrogen receptor-α (ERα) signalling. In the presence of LATS, ERα was targeted for ubiquitination and Ddb1–cullin4-associated-factor 1 (DCAF1)-dependent proteasomal degradation. Absence of LATS stabilized ERα and the Hippo effectors YAP and TAZ (hereafter YAP/TAZ), which together control breast cell fate through intrinsic and paracrine mechanisms. Our findings reveal a non-canonical (that is, YAP/TAZ-independent) effect of LATS in the regulation of human breast cell fate.
The structure of the bacterial ribosome stalled on a truncated mRNA in complex with ArfA and the release factor RF2 is presented, revealing how ArfA recruits RF2 to the ribosome and induces conformational changes within RF2 to enable translation termination in the absence of a stop codon.
The structure of the bacterial 70S ribosome in complex with ArfA, the release factor RF2, a short non-stop mRNA and a cognate P-site tRNA is presented, revealing how ArfA and RF2 facilitate alternative translation termination of the non-stop ribosomal complex using a stop-codon surrogate mechanism.
The structure of the bacterial ribosome in complex with the ArfA and the release factor RF2 shows how ArfA recruits RF2 to terminate translation of messenger RNAs that lack a stop codon in the ribosome.