네이처 컨텐츠

Editorials

Healing the traumatized minds of refugees p.139

Host countries need to deal with the raised levels of mental-health disorders in migrants if they expect them to integrate well, and that could mean benefits for psychological care in rich countries too.

doi: 10.1038/538139a

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News

News Features

News & Views

Megafloods downsized p.174

A fresh look at the Channeled Scablands of North America shows that the ancient floods that scarred that landscape were smaller than is commonly assumed. This result could revise estimates of similar floods on Mars. See Letter p.229

J. Taylor Perron & Jeremy G. Venditti

doi: 10.1038/538174a

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Measuring our narrow strip of life p.175

In line with previous research, a demographic analysis corroborates the presence of a limit to human lifespan, indicating that increases in life expectancy are likely to slow down or stop over the coming years.

S. Jay Olshansky

doi: 10.1038/nature19475

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Fifty years of C4 photosynthesis p.177

Half a century after the discovery of a plant photosynthetic pathway termed C4, researchers are working to engineer this efficient pathway into crops such as rice to maintain food security.

Julian M. Hibberd & Robert T. Furbank

doi: 10.1038/538177b

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A map of human wanderlust p.179

Genetic studies of individuals from geographically diverse human populations provide insights into the dispersal of modern humans across the globe and how geography shaped genomic variation. See Articles p.201 & p.207 & Letter p.238

Serena Tucci & Joshua M. Akey

doi: 10.1038/nature19472

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Lethal violence deep in the human lineage p.180

Researchers estimate that the incidence of human lethal violence at the time of the origin of our species was about six times higher than for the average mammal, but about as violent as expected, given our great-ape ancestry. See Letter p.233

Mark Pagel

doi: 10.1038/nature19474

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Reviews

In vitro and ex vivo strategies for intracellular delivery p.183

Intracellular delivery methods, which are critical to both fundamental research applications and cell-based therapies, are reviewed, concentrating on membrane-disruption-based methods and the use of nanotechnology, microfluidics and laboratory-on-chip technology.

Martin P. Stewart, Armon Sharei, Xiaoyun Ding, Gaurav Sahay, Robert Langer & Klavs F. Jensen

doi: 10.1038/nature19764

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Articles

The Simons Genome Diversity Project: 300 genomes from 142 diverse populations p.201

Deep whole-genome sequencing of 300 individuals from 142 diverse populations provides insights into key population genetic parameters, shows that all modern human ancestry outside of Africa including in Australasians is consistent with descending from a single founding population, and suggests a higher rate of accumulation of mutations in non-Africans compared to Africans since divergence.

Swapan Mallick, Heng Li, Mark Lipson, Iain Mathieson, Melissa Gymrek, Fernando Racimo, Mengyao Zhao, Niru Chennagiri, Susanne Nordenfelt, Arti Tandon + et al.

doi: 10.1038/nature18964

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A genomic history of Aboriginal Australia p.207

Whole-genome sequence data for 108 individuals representing 28 language groups across Australia and five language groups for Papua New Guinea suggests that Aboriginal Australians and Papuans diverged from Eurasian populations approximately 60–100 thousand years ago, following a single out-of-Africa dispersal and subsequent admixture with archaic populations.

Anna-Sapfo Malaspinas, Michael C. Westaway, Craig Muller, Vitor C. Sousa, Oscar Lao, Isabel Alves, Anders Bergström, Georgios Athanasiadis, Jade Y. Cheng, Jacob E. Crawford + et al.

doi: 10.1038/nature18299

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Letters

Enhanced flexoelectric-like response in oxide semiconductors p.219

Semiconducting single crystals of doped barium titanate and titanium dioxide exhibit a flexoelectric-like response upon bending that is much larger than in their undoped, insulating counterparts, reaching unprecedentedly large effective flexoelectric coefficients.

Jackeline Narvaez, Fabian Vasquez-Sancho & Gustau Catalan

doi: 10.1038/nature19761

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Molecular transport through capillaries made with atomic-scale precision p.222

Nanometre-scale graphitic capillaries with atomically flat walls are engineered and studied, revealing unexpectedly fast transport of liquid water through channels that accommodate only a few layers of water.

B. Radha, A. Esfandiar, F. C. Wang, A. P. Rooney, K. Gopinadhan, A. Keerthi, A. Mishchenko, A. Janardanan, P. Blake, L. Fumagalli + et al.

doi: 10.1038/nature19363

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Evolution of global temperature over the past two million years p.226

Reconstruction of global average surface temperature for the past two million years shows continuous cooling until about 1.2 million years ago, followed by a general flattening, with close coupling of global temperature and atmospheric greenhouse gas concentrations over the past 800,000 years.

Carolyn W. Snyder

doi: 10.1038/nature19798

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The phylogenetic roots of human lethal violence p.233

The percentage of human deaths caused by interpersonal violence reflects our membership of a particularly violent clade of mammals, although changes in socio-political organization have led to marked variations in this proportion.

José María Gómez, Miguel Verdú, Adela González-Megías & Marcos Méndez

doi: 10.1038/nature19758

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Genomic analyses inform on migration events during the peopling of Eurasia p.238

Whole-genome sequencing of individuals from 125 populations provides insight into patterns of genetic diversity, natural selection and human demographic history during the peopling of Eurasia and finds evidence for genetic vestiges of an early expansion of modern humans out of Africa in Papuans.

Luca Pagani, Daniel John Lawson, Evelyn Jagoda, Alexander Mörseburg, Anders Eriksson, Mario Mitt, Florian Clemente, Georgi Hudjashov, Michael DeGiorgio, Lauri Saag + et al.

doi: 10.1038/nature19792

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De novo assembly and phasing of a Korean human genome OPEN p.243

De novo assembly and phasing of the genome of an individual from Korea using a combination of different sequencing approaches provides a useful population-specific reference genome and represents the most contiguous human genome assembly so far.

Jeong-Sun Seo, Arang Rhie, Junsoo Kim, Sangjin Lee, Min-Hwan Sohn, Chang-Uk Kim, Alex Hastie, Han Cao, Ji-Young Yun, Jihye Kim + et al.

doi: 10.1038/nature20098

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Genome-wide associations for birth weight and correlations with adult disease p.248

Multi-ancestry genome-wide association analyses for birth weight in 153,781 individuals identified 60 genomic loci in which birth weight and fetal genotype were associated and found an inverse genetic correlation between birth weight and cardiometabolic risk.

Momoko Horikoshi, Robin N. Beaumont, Felix R. Day, Nicole M. Warrington, Marjolein N. Kooijman, Juan Fernandez-Tajes, Bjarke Feenstra, Natalie R. van Zuydam, Kyle J. Gaulton, Niels Grarup + et al.

doi: 10.1038/nature19806

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A cholinergic basal forebrain feeding circuit modulates appetite suppression p.253

A mouse study reveals that acetylcholine signalling networks have a role in the regulation of body weight homeostasis, with increased activity of cholinergic neurons decreasing food consumption through downstream hypothalamic targets.

Alexander M. Herman, Joshua Ortiz-Guzman, Mikhail Kochukov, Isabella Herman, Kathleen B. Quast, Jay M. Patel, Burak Tepe, Jeffrey C. Carlson, Kevin Ung, Jennifer Selever + et al.

doi: 10.1038/nature19789

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Evidence for a limit to human lifespan p.257

Demographic analysis of life expectancy and maximum reported age at death provides evidence that human lifespan has reached its natural limit.

Xiao Dong, Brandon Milholland & Jan Vijg

doi: 10.1038/nature19793

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Tissue-specific mutation accumulation in human adult stem cells during life p.260

Stem cells of the liver, colon and small intestine gradually accumulate mutations throughout life at a similar rate even though cancer incidence varies greatly among these tissues.

Francis Blokzijl, Joep de Ligt, Myrthe Jager, Valentina Sasselli, Sophie Roerink, Nobuo Sasaki, Meritxell Huch, Sander Boymans, Ewart Kuijk, Pjotr Prins + et al.

doi: 10.1038/nature19768

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Formation of new chromatin domains determines pathogenicity of genomic duplications p.265

Genomic duplications in the SOX9 region are associated with human disease phenotypes; a study using human cells and mouse models reveals that the duplications can cause the formation of new higher-order chromatin structures called topologically associated domains (TADs) thereby resulting in changes in gene expression.

Martin Franke, Daniel M. Ibrahim, Guillaume Andrey, Wibke Schwarzer, Verena Heinrich, Robert Schöpflin, Katerina Kraft, Rieke Kempfer, Ivana Jerković, Wing-Lee Chan + et al.

doi: 10.1038/nature19800

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