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Designing the ideal opioid p.170

The development of a drug that mimics the pain-relieving activity of opioid compounds, but has fewer side effects, points to an effective strategy for the discovery of many types of drug. See Article p.185

Brigitte L. Kieffer

doi: 10.1038/nature19424

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Slippery when narrow p.171

An experimental technique has been developed to measure water flow through carbon nanotubes. Measurements reveal that flow can be almost frictionless, posing challenges for computer simulations of nanofluidics. See Letter p.210

Angelos Michaelides

doi: 10.1038/537171a

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Mapping the terrestrial human footprint p.172

An analysis of direct human impacts across Earth's land surface using global satellite images and ground surveys reveals the scale of the 'human footprint' on the world and its changes between 1993 and 2009.

Philip J. K. McGowan

doi: 10.1038/537172a

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Violent emissions of newborn stars p.174

Interactions between young stars and their parent molecular clouds are poorly understood. High-resolution observations of the Orion nebula now reveal these interactions, which have implications for star formation. See Letter p.207

Markus Röllig

doi: 10.1038/537174a

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Catalytic spliceosome captured p.175

Spliceosome complexes remove non-coding sequences from RNA transcripts in two steps. A structure of a spliceosome after the first step reveals active-site interactions and evolutionary constraints on these non-coding regions. See Article p.197

Brian Kosmyna & Charles C. Query

doi: 10.1038/nature19422

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Fin to limb within our grasp p.176

There was thought to be little in common between fish fin bones and the finger bones of land-dwellers. But zebrafish studies reveal that hox genes have a surprisingly similar role in patterning the two structures. See Letter p.225

Aditya Saxena & Kimberly L. Cooper

doi: 10.1038/nature19425

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Articles

Structure-based discovery of opioid analgesics with reduced side effects p.185

Computational docking to the the μ-opioid-receptor identifies PZM21, a novel selective biased agonist that generates substantial affective analgesia in mice without altering respiration or inducing drug reinforcement.

Aashish Manglik, Henry Lin, Dipendra K. Aryal, John D. McCorvy, Daniela Dengler, Gregory Corder, Anat Levit, Ralf C. Kling, Viachaslau Bernat, Harald Hübner + et al.

doi: 10.1038/nature19112

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Letters

Compression and ablation of the photo-irradiated molecular cloud the Orion Bar p.207

One-arcsecond-resolution millimetre-wave images enable the surface of the Orion Bar molecular cloud to be resolved, revealing a fragmented ridge of high-density substructures, photoablative gas flows and instabilities that suggest that the cloud edge has been compressed by a high-pressure wave expanding into the molecular cloud, in contrast to predictions from static equilibrium models.

doi: 10.1038/nature18957

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Massive radius-dependent flow slippage in carbon nanotubes p.210

The pressure-driven flow rate through individual carbon nanotubes is precisely determined from the hydrodynamics of emerging water jets, revealing unexpectedly large and radius-dependent surface slippage.

Eleonora Secchi, Sophie Marbach, Antoine Niguès, Derek Stein, Alessandro Siria & Lydéric Bocquet

doi: 10.1038/nature19315

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Oxidative diversification of amino acids and peptides by small-molecule iron catalysis p.214

Two small-molecule iron catalysts are shown to be capable of facilitating the targeted C–H oxidative modification of amino acids and peptides with preservation of α-centre chirality (a challenging synthesis), producing a diverse range of amino acids and peptides.

Thomas J. Osberger, Donald C. Rogness, Jeffrey T. Kohrt, Antonia F. Stepan & M. Christina White

doi: 10.1038/nature18941

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A progressively wetter climate in southern East Africa over the past 1.3 million years p.220

A 1.3-million-year-long climate history from the Lake Malawi basin in eastern Africa displays a trend towards progressively wetter conditions superimposed on strong 100,000-year eccentricity cycles of temperature and rainfall since the Mid-Pleistocene Transition around 900,000 years ago.

T. C. Johnson, J. P. Werne, E. T. Brown, A. Abbott, M. Berke, B. A. Steinman, J. Halbur, S. Contreras, S. Grosshuesch, A. Deino + et al.

doi: 10.1038/nature19065

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Digits and fin rays share common developmental histories p.225

Hoxa- and Hoxd-deficient zebrafish generated using Crispr/Cas with fate mapping have reduced fin rays and increased endochondral elements, establishing homology between the developmental programs that create fin rays and the wrists and digits of mammals.

Tetsuya Nakamura, Andrew R. Gehrke, Justin Lemberg, Julie Szymaszek & Neil H. Shubin

doi: 10.1038/nature19322

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Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness p.229

A selective inhibitor of the kinetoplastid proteasome (GNF6702) is identified that is highly efficacious in vivo, clearing the parasites that cause leishmaniasis, Chagas disease and sleeping sickness from mice, highlighting the possibility of developing a single class of drugs for these neglected diseases.

Shilpi Khare, Advait S. Nagle, Agnes Biggart, Yin H. Lai, Fang Liang, Lauren C. Davis, S. Whitney Barnes, Casey J. N. Mathison, Elmarie Myburgh, Mu-Yun Gao + et al.

doi: 10.1038/nature19339

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The long non-coding RNA Morrbid regulates Bim and short-lived myeloid cell lifespan p.239

The long non-coding RNA Morrbid controls myeloid cell lifespan and regulates apoptosis by repressing the adjacent pro-apoptotic Bcl2l11 gene in cis.

Jonathan J. Kotzin, Sean P. Spencer, Sam J. McCright, Dinesh B. Uthaya Kumar, Magalie A. Collet, Walter K. Mowel, Ellen N. Elliott, Asli Uyar, Michelle A. Makiya, Margaret C. Dunagin + et al.

doi: 10.1038/nature19346

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Insights from biochemical reconstitution into the architecture of human kinetochores p.249

Biochemical reconstitution of a synthetic human kinetochore with 21 protein subunits and centromeric nucleosomal DNA unveils fundamental principles of kinetochore organization and function.

John R. Weir, Alex C. Faesen, Kerstin Klare, Arsen Petrovic, Federica Basilico, Josef Fischböck, Satyakrishna Pentakota, Jenny Keller, Marion E. Pesenti, Dongqing Pan + et al.

doi: 10.1038/nature19333

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