네이처 컨텐츠

Editorial

Go forth and replicate! p.373

To make replication studies more useful, researchers must make more of them, funders must encourage them and journals must publish them.

doi: 10.1038/536373a

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News

News Features

News & Views

Generation soft p.400

Meet the octobot, the first robot to be made entirely from soft materials. Powered by a chemical reaction and controlled by a fluidic logic circuit, it heralds a generation of soft robots that might surpass conventional machines. See Letter p.451

Barbara Mazzolai & Virgilio Mattoli

doi: 10.1038/536400a

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Friendly neighbours feed tumour cells p.401

In pancreatic cancer, neighbouring non-cancerous cells degrade their own proteins through a process called autophagy and release amino acids that are then taken up and used by the cancer cells. See Letter p.479

Jurre J. Kamphorst & Eyal Gottlieb

doi: 10.1038/nature19420

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Signal locked in p.402

A plant receptor protein interacts in an unusual way with the hormone it binds. The receptor cleaves the hormone, a fragment of which then binds covalently to the receptor and triggers a major receptor shape change. See Letter p.469

Kimberley C. Snowden & Bart J. Janssen

doi: 10.1038/nature19418

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Fleeting glimpse of an elusive element p.404

A heroic effort to characterize the chemistry of actinium, a short-lived radioactive element, reveals surprising differences in behaviour compared with other elements in the actinide series.

Thomas E. Albrecht-Schmitt

doi: 10.1038/536404a

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Memories linked within a window of time p.405

In mice, two fear-associated memories that are created close in time are represented in the brain's amygdala by the activation of overlapping ensembles of neurons. As a result, eliminating the fear of one memory also extinguishes fear of the other.

Howard Eichenbaum

doi: 10.1038/536405a

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Mitotic regulation comes into focus p.407

Structural studies provide insight into the mechanisms governing a checkpoint in cell division that prevents chromosomes from segregating before they are properly aligned on a structure called the mitotic spindle. See Article p.431

David O. Morgan

doi: 10.1038/nature19423

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Earth-like planet around Sun's neighbour p.408

An Earth-mass planet has been discovered in orbit around Proxima Centauri, the closest star to our Sun. The planet orbits at a distance from the star such that liquid water and potentially life could exist on its surface. See Letter p.437

Artie P. Hatzes

doi: 10.1038/536408a

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Articles

Early onset of industrial-era warming across the oceans and continents p.411

Reconstructions of ocean and land temperatures since ad 1500 indicate that sustained, industrial-era warming of land areas in the Northern Hemisphere and tropical oceans began earlier than previously thought, around the mid-nineteenth century.

Nerilie J. Abram, Helen V. McGregor, Jessica E. Tierney, Michael N. Evans, Nicholas P. McKay, Darrell S. Kaufman & Kaustubh Thirumalai

doi: 10.1038/nature19082

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Genomic insights into the origin of farming in the ancient Near East p.419

Analysis of DNA from ancient individuals of the Near East documents the extreme substructure among the populations which transitioned to farming, a structure that was maintained throughout the transition from hunter–gatherer to farmer but that broke down over the next five thousand years.

Iosif Lazaridis, Dani Nadel, Gary Rollefson, Deborah C. Merrett, Nadin Rohland, Swapan Mallick, Daniel Fernandes, Mario Novak, Beatriz Gamarra, Kendra Sirak + et al.

doi: 10.1038/nature19310

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Uncovering Earth’s virome p.425

An integrated computational approach that explores the viral content of more than 3,000 metagenomic samples collected globally highlights the existing global viral diversity, increases the known number of viral genes by an order of magnitude, and provides detailed insights into viral distribution across diverse ecosystems and into virus–host interactions.

David Paez-Espino, Emiley A. Eloe-Fadrosh, Georgios A. Pavlopoulos, Alex D. Thomas, Marcel Huntemann, Natalia Mikhailova, Edward Rubin, Natalia N. Ivanova & Nikos C. Kyrpides

doi: 10.1038/nature19094

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Molecular basis of APC/C regulation by the spindle assembly checkpoint p.431

A high-resolution structure of a complex between the anaphase-promoting complex (APC/C) and the mitotic checkpoint complex (MCC) reveals how MCC interacts with and represses APC/C by obstructing substrate recognition and suppressing E3 ligase activity.

Claudio Alfieri, Leifu Chang, Ziguo Zhang, Jing Yang, Sarah Maslen, Mark Skehel & David Barford

doi: 10.1038/nature19083

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Letters

A terrestrial planet candidate in a temperate orbit around Proxima Centauri p.437

A small planet of at least 1.3 Earth masses is orbiting Proxima Centauri with a period of about 11.2 days, with the potential for liquid water on its surface.

Guillem Anglada-Escudé, Pedro J. Amado, John Barnes, Zaira M. Berdiñas, R. Paul Butler, Gavin A. L. Coleman, Ignacio de la Cueva, Stefan Dreizler, Michael Endl, Benjamin Giesers + et al.

doi: 10.1038/nature19106

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Extending the lifetime of a quantum bit with error correction in superconducting circuits p.441

A quantum-error-correction system is demonstrated in which natural errors due to energy loss are suppressed by encoding a logical state as a superposition of Schrödinger-cat states, which results in the system reaching the ‘break-even’ point, at which the lifetime of a qubit exceeds the lifetime of the constituents of the system.

Nissim Ofek, Andrei Petrenko, Reinier Heeres, Philip Reinhold, Zaki Leghtas, Brian Vlastakis, Yehan Liu, Luigi Frunzio, S. M. Girvin, L. Jiang + et al.

doi: 10.1038/nature18949

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Biodiversity at multiple trophic levels is needed for ecosystem multifunctionality p.456

Both a high number of species and abundance in multiple trophic levels are required for ecosystems to continue to provide the services humans require of them.

Santiago Soliveres, Fons van der Plas, Peter Manning, Daniel Prati, Martin M. Gossner, Swen C. Renner, Fabian Alt, Hartmut Arndt, Vanessa Baumgartner, Julia Binkenstein + et al.

doi: 10.1038/nature19092

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The TRPM2 ion channel is required for sensitivity to warmth p.460

The neuronal mechanism for the detection of non-painful warm stimuli has remained unclear; mammalian TRPM2 ion channel is shown to be required for warmth detection in the non-noxious range of 33–38 °C, and surprisingly to mediate responses to warmth in the autonomic nervous system.

Chun-Hsiang Tan & Peter A. McNaughton

doi: 10.1038/nature19074

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The prion protein is an agonistic ligand of the G protein-coupled receptor Adgrg6 p.464

The cellular prion protein PrPC promotes peripheral myelin homeostasis by acting on a G protein-coupled receptor to increase levels of cyclic AMP in Schwann cells.

Alexander Küffer, Asvin K. K. Lakkaraju, Amit Mogha, Sarah C. Petersen, Kristina Airich, Cédric Doucerain, Rajlakshmi Marpakwar, Pamela Bakirci, Assunta Senatore, Arnaud Monnard + et al.

doi: 10.1038/nature19312

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DWARF14 is a non-canonical hormone receptor for strigolactone p.469

Structural, biochemical, mass spectrometry and genetic analyses define Arabidopsis thaliana AtD14 as a non-canonical hormone receptor for strigolactone, which hydrolyses strigolactone into a covalently linked intermediate molecule and undergoes an open-to-closed state transition for interaction with D3 to trigger strigolactone signalling.

Ruifeng Yao, Zhenhua Ming, Liming Yan, Suhua Li, Fei Wang, Sui Ma, Caiting Yu, Mai Yang, Li Chen, Linhai Chen + et al.

doi: 10.1038/nature19073

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Vaccine protection against Zika virus from Brazil p.474

The authors test several candidate vaccines for Zika virus in mouse models and show that single-shot DNA vaccines and inactivated virus vaccines provide complete protection against Zika virus isolates from Brazil and Puerto Rico.

Rafael A. Larocca, Peter Abbink, Jean Pierre S. Peron, Paolo M. de A. Zanotto, M. Justin Iampietro, Alexander Badamchi-Zadeh, Michael Boyd, David Ng’ang’a, Marinela Kirilova, Ramya Nityanandam + et al.

doi: 10.1038/nature18952

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Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion p.479

Pancreatic adenocarcinoma cells drive autophagy in tumour microenvironment-associated stellate cells, which release alanine that is used by the cancer cells as a carbon source for a variety of metabolic processes in an otherwise nutrient-poor environment.

Cristovão M. Sousa, Douglas E. Biancur, Xiaoxu Wang, Christopher J. Halbrook, Mara H. Sherman, Li Zhang, Daniel Kremer, Rosa F. Hwang, Agnes K. Witkiewicz, Haoqiang Ying + et al.

doi: 10.1038/nature19084

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Diverse activation pathways in class A GPCRs converge near the G-protein-coupling region p.484

A highly conserved rearrangement of residue contacts functions as a common step in the activation pathways of diverse G-protein-coupled receptors.

A. J. Venkatakrishnan, Xavier Deupi, Guillaume Lebon, Franziska M. Heydenreich, Tilman Flock, Tamara Miljus, Santhanam Balaji, Michel Bouvier, Dmitry B. Veprintsev, Christopher G. Tate + et al.

doi: 10.1038/nature19107

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