Volume 536 Number 7614

Editorials

News

News Features

News & Views

Death-defying plaque cells p.32

Dead cells are usually removed through their ingestion and destruction by other cells. A study of plaque deposits in arteries shows that dying cells in plaques display a 'don't-eat-me' signal that blocks their removal. See Letter p.86

doi: 10.1038/nature18916

Bacteria synchronized for drug delivery p.33

A synthetic genetic circuit that mimics the quorum-sensing systems used by bacterial populations to coordinate gene expression enables bacteria to deliver drugs to mouse tumours in repeated and synchronized cycles. See Letter p.81

doi: 10.1038/nature18915

A milestone in quantum computing p.35

Quantum computers require many quantum bits to perform complex calculations, but devices with more than a few bits are difficult to program. A device based on five atomic quantum bits shows a way forward. See Letter p.63

doi: 10.1038/536035a

Protection for anaesthetized mice p.36

A cognition-enhancing drug called CX546 prevents the neurodegenerative effects of repeated anaesthesia in infant mice by promoting neuronal changes associated with learning and by protecting neurons from death.

doi: 10.1038/536036a

Still a geneticist's nightmare p.37

The largest DNA-sequencing study of type 2 diabetes conducted so far concludes that, contrary to expectation, low-frequency and rare genetic variants do not contribute significantly to disease risk. See Article p.41

doi: 10.1038/nature18906

Destruction of discrete charge p.38

Electric charge is quantized in units of the electron's charge. An experiment explores the suppression of charge quantization caused by quantum fluctuations and supports a long-standing theory that explains this behaviour. See Letter p.58

doi: 10.1038/536038a

Articles

The genetic architecture of type 2 diabetes p.41

Sequencing data from two large-scale studies show that most of the genetic variation influencing the risk of type 2 diabetes involves common alleles and is found in regions previously identified by genome-wide association studies, clarifying the genetic architecture of this disease.

doi: 10.1038/nature18642

Letters

Controlling charge quantization with quantum fluctuations p.58

A device consisting of a metallic island connected to electrodes via tunable semiconductor-based conduction channels is used to explore the evolution of charge quantization in the presence of quantum fluctuations; the measurements reveal a robust scaling of charge quantization as the square root of the residual electron reflection probability across a quantum channel, consistent with theoretical predictions.

doi: 10.1038/nature19072

Carbon-based tribofilms from lubricating oils p.67

Moving mechanical interfaces need to be lubricated to ensure long life and easy slippage; here, a new type of coating is described—comprising nitrides of either molybdenum or vanadium, together with a copper or nickel catalyst—that generates protective tribofilms from lubricating oils.

doi: 10.1038/nature18948

Evidence for climate change in the satellite cloud record p.72

Satellite records show that the global pattern of cloud changes between the 1980s and the 2000s are similar to the patterns predicted by models of climate with recent external radiative forcing, and that the primary drivers of the cloud changes appear to be increasing greenhouse gas concentrations and a recovery from volcanic radiative cooling.

doi: 10.1038/nature18273

The structural basis of modified nucleosome recognition by 53BP1 p.100

A cryo-electron microscopy structure of the DNA damage repair protein 53BP1 bound to a nucleosome illuminates the way 53BP1 recognizes two types of histone modifications (a methyl group and a ubiquitin moiety), and provides insight into the highly specified recognition and recruitment of 53BP1 to modified chromatin.

doi: 10.1038/nature18951