Researchers and policymakers are now free to tackle the most-pressing GM issues p.199
A US Senate decision on labelling genetically modified foods paves the way for a redirection of resources.doi: 10.1038/535199a
Volume 535 Issue 7611
리서치 하이라이트
표지 기사： 자발적 자가-티어링과 필링에 의한 자가 조립형 그래핀 리본
종과 온도 레벨에 따른 기후와 관련된 생물 계절학적 민감도
신경 모세포종에서 let-7 마이크로 RNA 계열
CRL4CRBN 유비쿼틴 리가아제에 GSPT1을 모집하는 새로운 세레블론 조절인자
슈레딩거의 고양이 상태에서 뤼드베리 원자를 기반으로 한 민감한 일렉트로미터 개발
해양 암석권의 극단적인 형태를 밝힌 미드 오션 리지의 지진파 특성
나비의 색각 확장과 관련된 3가지 타입의 확률적인 선택과 관련된 분자 생물학적 로직
유인원의 등쪽 스템에서 의사 결정과 관련된 활성에 대한 분리 기능의 중요성
초기 낭배 형성과 관련된 단일 세포 트랜스크립톰 분석
컨텐츠
Editorials
The people who don’t get ‘Eleanor Rigby’ p.199
Happy music and sad sounds are not universal.doi: 10.1038/535199b
Fifty shades of pain p.200
Measuring hurt is harder than inflicting it.doi: 10.1038/535200a
News
South Africa’s political turmoil endangers research p.207
Economic instability and campus violence have thrown labs into crisis.doi: 10.1038/535207a
Mobile-phone expansion could disrupt key weather satellites p.208
The US government is considering a plan to allow wireless firms to share radio frequencies used in weather forecasts.doi: 10.1038/535208a
Brain-data gold mine could reveal how neurons compute p.209
Allen Brain Observatory releases unprecedented survey of activity in the mouse visual cortex.doi: 10.1038/535209a
Beat it, impact factor! Publishing elite turns against controversial metric p.210
Senior staff at leading journals want to end inappropriate use of the measure.doi: 10.1038/nature.2016.20224
Men cite themselves more than women do p.212
The apparent trend has been on the rise over the past two decades.doi: 10.1038/nature.2016.20176
Germany’s renewable revolution awaits energy forecast p.212
Poster-child for renewables strives to make wind and solar power more grid-friendly.doi: 10.1038/535212a
News Features
South Africa ushers in a new era for HIV p.214
The country has developed the biggest programme of antiretroviral therapy in the world. Now scientists are exploring the long-term consequences of the drugs.doi: 10.1038/535214a
How China is rewriting the book on human origins p.218
Fossil finds in China are challenging ideas about the evolution of modern humans and our closest relatives.doi: 10.1038/535218a
News & Views
A sticky problem for chromosomes p.234
The role of Ki-67 in mitotic cell division has been a mystery. Extensive imaging reveals that this highly positively charged protein coats chromosomes to prevent them from coalescing. See Letter p.308doi: 10.1038/nature18904
Magnetic nanoparticles line up p.235
Certain bacteria contain strings of magnetic nanoparticles and therefore align with magnetic fields. Inspired by these natural structures, researchers have now fabricated synthetic one-dimensional arrays of such particles.doi: 10.1038/535235a
Interactions of climate change and species p.236
At what times of year are phenological events across species sensitive to climatic variables, and how sensitive are they? Answers to these questions emerge from the analysis of a wealth of long-term data sets. See Article p.241doi: 10.1038/nature18905
Variable snow lines affect planet formation p.237
Observations of the disk of dust and gas around a nascent star reveal that the distance from the star at which water in the disk forms ice is variable. This variation might hinder the formation of planets. See Letter p.258doi: 10.1038/535237a
Schrödinger's cat beats a quantum limit p.238
Quantum effects have been used in devices that measure various quantities, but not to measure electric fields. The sensitivity of an electrometer has now been boosted using the phenomenon of quantum superposition. See Letter p.262doi: 10.1038/535238a
Articles
Phenological sensitivity to climate across taxa and trophic levels p.241
An ambitious study has used more than 10,000 datasets to examine how the phenological characteristics—such as the timing of reproduction—of various taxa alter in response to climate change, and suggests that differing levels of climate sensitivity could lead to the desynchronization of seasonal events over time.doi: 10.1038/nature18608
Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma p.246
Disparate modes of suppression of the let-7 microRNA family are selectively and inversely related in neuroblastoma.doi: 10.1038/nature18632
A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase p.252
This paper reports the identification of a new cereblon-modulating agent, CC-885, which targets the translation termination factor GSPT1 and demonstrates anti-tumour activity in patient-derived tumour cells; the crystal structure of the cereblon–DDB1–GSPT1–CC-885 complex reveals a common motif for cereblon-substrate recruitment.doi: 10.1038/nature18611
Letters
Imaging the water snow-line during a protostellar outburst p.258
The snow-line is the distance from a protostar at which a particular volatile gas condenses; images of the protostar V883 Ori suggest that the water snow-line migrated outwards during a protostellar outburst, with implications for our understanding of the formation of planetary systems such as our own.doi: 10.1038/nature18612
A sensitive electrometer based on a Rydberg atom in a Schrödinger-cat state p.262
A highly sensitive electrometer is reported that is based on a Schrödinger-cat state in a Rydberg atom, that reaches a sensitivity beyond the standard quantum limit and can compete with state-of-the-art electric field measurements performed using electromechanical resonators and single-electron transistors.doi: 10.1038/nature18327
Transport evidence for Fermi-arc-mediated chirality transfer in the Dirac semimetal Cd3As2 p.266
Electronic transport measurements in a magnetic field on the topological Dirac semimetal Cd3As2 identify the predicted Weyl orbits that weave Fermi arcs and bulk states together; the Weyl orbits enable transfer of chirality from one node to another, and open up the possibility of controlling topological properties electronically.doi: 10.1038/nature18276
Self-assembly of graphene ribbons by spontaneous self-tearing and peeling from a substrate p.271
The controllable self-assembly of graphene ribbons on a substrate is shown, demonstrating an effect which could be applied to patterning and actuating devices made from two-dimensional materials.doi: 10.1038/nature18304
Mid-ocean-ridge seismicity reveals extreme types of ocean lithosphere p.276
The structure and accretion modes of two end-member types of oceanic lithosphere are described using a detailed seismicity survey along 390 kilometres of an ultraslow ridge axis, indicating deeper seismicity in amagmatic regions and explaining the uneven crustal production at ultraslow-spreading ridges.doi: 10.1038/nature18277
Molecular logic behind the three-way stochastic choices that expand butterfly colour vision p.280
Butterflies diversify their retinal mosaics by producing three stochastic types of ommatidia instead of the two types found in Drosophila; this study shows that butterfly retinas use two R7-like photoreceptors per ommatidium that each make an independent stochastic decision to express the transcription factor Spineless, which controls photoreceptor and ommatidial fate.doi: 10.1038/nature18616
Dissociated functional significance of decision-related activity in the primate dorsal stream p.285
Activity in regions of the brain have been correlated with decision making but determining whether such relationships are correlative or causative has been challenging; using a technique to reversibly inactivate brain areas in monkeys reveals that although there is decision-related activity in the lateral intraparietal (LIP) area, LIP is not critical for the perceptual decisions studied here.doi: 10.1038/nature18617
Resolving early mesoderm diversification through single-cell expression profiling p.289
Analysis of the transcriptome of more than 1,200 cells from gastrulating mouse embryos using single-cell sequencing, gathering unexpected insights into early mesoderm formation during gastrulation.doi: 10.1038/nature18633
Cloche is a bHLH-PAS transcription factor that drives haemato-vascular specification p.294
The zebrafish cloche gene is required for the formation of most endothelial and haematopoietic cells, however, it has been difficult to isolate; this study reveals that cloche encodes a PAS-domain-containing bHLH transcription factor, and a mammalian orthologue can partially rescue cloche mutants, indicating a possible conserved role in mammals.doi: 10.1038/nature18614
Early myeloid lineage choice is not initiated by random PU.1 to GATA1 protein ratios p.299
Live imaging and single-cell analyses are used to show that decision-making by differentiating haematopoietic stem cells between the megakaryocytic–erythroid and granulocytic–monocytic lineages is not initiated by stochastic switching between the lineage-specific transcription factors PU.1 and GATA1, which challenges the previous model of early myeloid lineage choice.doi: 10.1038/nature18320
TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis p.303
In mice, deficiency in the high-density lipoprotein gene T39 stabilizes liver X receptor (LXR), reducing both atherosclerosis and steatohepatitis, suggesting that T39 inhibition could be an effective strategy for reducing these diseases.doi: 10.1038/nature18628
Ki-67 acts as a biological surfactant to disperse mitotic chromosomes p.308
During cell division, chromosomes are maintained as individual units; this process is shown to be mediated by the cell proliferation marker Ki-67, which has biophysical properties similar to those of surfactants.doi: 10.1038/nature18610
