네이처 컨텐츠

Editorials

Non-expert nation p.589

Scientists — just like everybody else — have little idea what will happen now that the United Kingdom has voted to exit the European Union.

doi: 10.1038/534589a

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News

News Features

News & Views

The dark side of antibiotics p.624

Interactions in the gut between host cells and bacteria can determine a state of health or disease. A study investigates how antibiotic treatment can affect host cells in a way that drives growth of pathogenic bacteria. See Letter p.697

Thibault G. Sana & Denise M. Monack

doi: 10.1038/nature18449

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Stressed-out chromatin promotes longevity p.625

Two studies reveal that early-life malfunction in organelles called mitochondria brings about lasting changes in how DNA is packaged. These alterations have consequences for cellular stress responses and organismal longevity.

Siu Sylvia Lee & Jessica K. Tyler

doi: 10.1038/534625a

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An extended yardstick for climate variability p.626

Decoded and precisely dated information encrypted in stalagmites from a cave in China reveal past climatic changes and provide insight into the complex interactions in today's climate system. See Letter p.640

Nele Meckler

doi: 10.1038/534626a

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Transmissible tumours under the sea p.628

In some species, cancer cells can be directly transmitted between individuals. An analysis in shellfish now shows that some transmissible cancers can even cross the species barrier. See Letter p.705

Elizabeth P. Murchison

doi: 10.1038/nature18455

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Perspective

Paris Agreement climate proposals need a boost to keep warming well below 2 °C p.631

The objective of the Paris climate agreement is to limit global-average temperature increase to well below 2 degrees Celsius above pre-industrial levels and to further pursue limiting it to 1.5 degrees Celsius; here, the adequacy of the national plans submitted in preparation for this agreement is assessed, and it is concluded that substantial enhancement or over-delivery on these plans is required to have a reasonable chance of achieving the Paris climate objective.

Joeri Rogelj, Michel den Elzen, Niklas Höhne, Taryn Fransen, Hanna Fekete, Harald Winkler, Roberto Schaeffer, Fu Sha, Keywan Riahi & Malte Meinshausen

doi: 10.1038/nature18307

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Articles

The Asian monsoon over the past 640,000 years and ice age terminations p.640

Records of the Asian monsoon have been extended to 640,000 years ago, and confirm both that the 100,000-year ice age cycle results from integral numbers of precessional cycles and that insolation influences the pacing of major millennial-scale climate events.

Hai Cheng, R. Lawrence Edwards, Ashish Sinha, Christoph Spötl, Liang Yi, Shitao Chen, Megan Kelly, Gayatri Kathayat, Xianfeng Wang, Xianglei Li + et al.

doi: 10.1038/nature18591

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A combinatorial strategy for treating KRAS-mutant lung cancer p.647

A systematic screen identifies FGFR1 signalling reactivation as an adaptive resistance mechanism after MEK inhibition specific for KRAS tumours, which can be targeted by combined inhibition with the clinically approved drugs trametinib and ponatinib.

Eusebio Manchado, Susann Weissmueller, John P. Morris, Chi-Chao Chen, Ramona Wullenkord, Amaia Lujambio, Elisa de Stanchina, John T. Poirier, Justin F. Gainor, Ryan B. Corcoran + et al.

doi: 10.1038/nature18600

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The landscape of accessible chromatin in mammalian preimplantation embryos p.652

An improved ATAC-seq approach is used to describe a genome-wide view of accessible chromatin and cis-regulatory elements in mouse preimplantation embryos, allowing construction of a regulatory network of early development that helps to identify key modulators of lineage specification.

Jingyi Wu, Bo Huang, He Chen, Qiangzong Yin, Yang Liu, Yunlong Xiang, Bingjie Zhang, Bofeng Liu, Qiujun Wang, Weikun Xia + et al.

doi: 10.1038/nature18606

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Letters

A Neptune-sized transiting planet closely orbiting a 5–10-million-year-old star p.658

A fully formed, Neptune-sized planet is observed orbiting a young star, demonstrating that planets can form in less than 10 million years and may also experience inward migration on these timescales.

Trevor J. David, Lynne A. Hillenbrand, Erik A. Petigura, John M. Carpenter, Ian J. M. Crossfield, Sasha Hinkley, David R. Ciardi, Andrew W. Howard, Howard T. Isaacson, Ann Marie Cody + et al.

doi: 10.1038/nature18293

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A hot Jupiter orbiting a 2-million-year-old solar-mass T Tauri star p.662

The radial velocities of a young star are measured, revealing the presence of a planet of mass about three-quarters that of Jupiter, orbiting its host star very closely, and thus demonstrating that ‘hot Jupiters’ can migrate inwards in less than two million years.

J. F. Donati, C. Moutou, L. Malo, C. Baruteau, L. Yu, E. Hébrard, G. Hussain, S. Alencar, F. Ménard, J. Bouvier + et al.

doi: 10.1038/nature18305

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Tunable two-dimensional arrays of single Rydberg atoms for realizing quantum Ising models p.667

Many proof-of-principle platforms for quantum simulation of spin models have been implemented, but it is difficult to produce a design with sufficient flexibility to realize arbitrary geometries and variable distance; here a platform based on arrays of optical microtraps achieves this flexibility with large atom numbers.

Henning Labuhn, Daniel Barredo, Sylvain Ravets, Sylvain de Léséleuc, Tommaso Macrì, Thierry Lahaye & Antoine Browaeys

doi: 10.1038/nature18274

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Synthetic Landau levels for photons p.671

It is an long-standing goal to produce a photonic quantum Hall effect, analogous to the well-known quantum Hall effect for electrons; now an artificial magnetic field for a continuum of photons has been produced, making it possible to observe photonic Landau levels in a photonic quantum Hall material.

Nathan Schine, Albert Ryou, Andrey Gromov, Ariel Sommer & Jonathan Simon

doi: 10.1038/nature17943

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Switching stiction and adhesion of a liquid on a solid p.676

Switching of static friction and adhesion of a liquid drop on a corrugated solid boron nitride surface is linked to the intercalation of hydrogen, which changes the electric field of in-plane dipole rings and thus reduces the adsorption energy.

Stijn F. L. Mertens, Adrian Hemmi, Stefan Muff, Oliver Gröning, Steven De Feyter, Jürg Osterwalder & Thomas Greber

doi: 10.1038/nature18275

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Seasonality of temperate forest photosynthesis and daytime respiration p.680

Climate models require an understanding of ecosystem-scale respiration and photosynthesis, yet there is no way of measuring these two fluxes directly; here, new instrumentation is used to determine these fluxes in a temperate forest, showing, for instance, that respiration is less during the day than at night.

R. Wehr, J. W. Munger, J. B. McManus, D. D. Nelson, M. S. Zahniser, E. A. Davidson, S. C. Wofsy & S. R. Saleska

doi: 10.1038/nature17966

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Basal forebrain projections to the lateral habenula modulate aggression reward p.688

Here, the circuits underlying the motivational or rewarding component to aggression are deconstructed, showing that an inhibitory projection from the basal forebrain to the lateral habenula bi-directionally controls this aspect of aggression.

Sam A. Golden, Mitra Heshmati, Meghan Flanigan, Daniel J. Christoffel, Kevin Guise, Madeline L. Pfau, Hossein Aleyasin, Caroline Menard, Hongxing Zhang, Georgia E. Hodes + et al.

doi: 10.1038/nature18601

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Rates and mechanisms of bacterial mutagenesis from maximum-depth sequencing p.693

Maximum-depth sequencing (MDS), a new method of detecting extremely rare variants within a bacterial population, is used to show that mutation rates in Escherichia coli vary across the genome by at least an order of magnitude, and also to uncover mechanisms of antibiotic-induced mutagenesis.

Justin Jee, Aviram Rasouly, Ilya Shamovsky, Yonatan Akivis, Susan R. Steinman, Bud Mishra & Evgeny Nudler

doi: 10.1038/nature18313

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Host-mediated sugar oxidation promotes post-antibiotic pathogen expansion p.697

Antibiotic usage in humans can increase the risk of Salmonella infection by an unknown mechanism; this paper reveals that the antibiotic streptomycin increases the activity of the host-encoded enzyme inducible nitric oxide synthase, this then drives Salmonella expansion by the generation of galactarate — a metabolite normally absent from the gut.

Franziska Faber, Lisa Tran, Mariana X. Byndloss, Christopher A. Lopez, Eric M. Velazquez, Tobias Kerrinnes, Sean-Paul Nuccio, Tamding Wangdi, Oliver Fiehn, Renée M. Tsolis + et al.

doi: 10.1038/nature18597

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Widespread transmission of independent cancer lineages within multiple bivalve species p.705

Disseminated neoplasias in three species of bivalve mollusc are attributed to transmissible clonal lines, and neoplasias in one species are caused by cross-species transmission of cancer, suggesting that transmissible neoplasia is common in marine species.

Michael J. Metzger, Antonio Villalba, María J. Carballal, David Iglesias, James Sherry, Carol Reinisch, Annette F. Muttray, Susan A. Baldwin & Stephen P. Goff

doi: 10.1038/nature18599

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H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex p.714

We have a limited understanding of how cells mark and identify newly replicated genomic loci that have a sister chromatid; here, unmethylated K20 in the tail of new histone H4 is shown to serve as a signature of post-replicative chromatin, which is specifically recognized by the homologous recombination complex TONSL–MMS22L.

Giulia Saredi, Hongda Huang, Colin M. Hammond, Constance Alabert, Simon Bekker-Jensen, Ignasi Forne, Nazaret Reverón-Gómez, Benjamin M. Foster, Lucie Mlejnkova, Till Bartke + et al.

doi: 10.1038/nature18312

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Translation readthrough mitigation p.719

Translation termination sequences are occasionally bypassed by the ribosome and the resulting proteins can be detrimental to the cell; here it is shown that cells can prevent such proteins from accumulating through peptides that are encoded within the 3' UTR of genes in both humans and C. elegans.

Joshua A. Arribere, Elif S. Cenik, Nimit Jain, Gaelen T. Hess, Cameron H. Lee, Michael C. Bassik & Andrew Z. Fire

doi: 10.1038/nature18308

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