네이처 컨텐츠

Editorials

Data sharing p.435

Pooling clinical details helps doctors to diagnose rare diseases — but more sharing is needed.

doi: 10.1038/534435b

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Way of the dragon p.435

To boost its research quality and innovation, China must strengthen its scientific foundations and let researchers — not policymakers — set the agenda for innovation and discovery.

doi: 10.1038/534435a

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At gunpoint p.436

The problem of gun violence in the United States must finally be addressed.

doi: 10.1038/534436a

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News

News Features

Science in China p.451

A special issue looks at the country's astonishing scientific trajectory as it seeks to secure its spot among the leaders in innovation.

doi: 10.1038/534451a

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China by the numbers p.452

Research capacity has grown rapidly, and now quality is on the rise.

Richard Van Noorden

doi: 10.1038/534452a

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Science stars of China p.456

From ancient DNA to neutrinos and neuroscience, top researchers in China are making big impacts — and raising their country’s standing in science.

doi: 10.1038/534456a

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News & Views

Recipe for a black-hole merger p.478

The detection of a gravitational wave was a historic event that heralded a new phase of astronomy. A numerical model of the Universe now allows researchers to tell the story of the black-hole system that caused the wave. See Letter p.512

J. J. Eldridge

doi: 10.1038/534478a

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Membrane kiss mediates hormone secretion p.479

Communication between cells relies on hormone release from secretory granules, but how these vesicles fuse with cell membranes is unclear. An imaging study provides in vivo evidence for a stable intermediate fusion step. See Letter p.548

Tolga Soykan & Volker Haucke

doi: 10.1038/nature18446

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Quantum simulation of fundamental physics p.480

Gauge theories underpin the standard model of particle physics, but are difficult to study using conventional computational methods. An experimental quantum system opens up fresh avenues of investigation. See Letter p.516

Erez Zohar

doi: 10.1038/534480a

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Gene regulation in transition p.482

An in-depth analysis of a close relative of animals, Capsaspora owczarzaki, provides clues to the changes in gene regulation that occurred during the transition to multicellularity.

David S. Booth & Nicole King

doi: 10.1038/nature18447

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Synergy of a warm spring and dry summer p.483

An analysis suggests that high carbon uptake by US land ecosystems during the warm spring of 2012 offset the carbon loss that resulted from severe drought over the summer — and hints that the warm spring could have worsened the drought.

Yude Pan & David Schimel

doi: 10.1038/nature18450

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When sperm meets egg p.484

Sperm–egg binding is mediated by two cell-surface proteins. Structural analysis of these proteins separately and in complex provides insight into the recognition process and the subsequent sperm–egg fusion. See Letters p.562 & p.566

Karsten Melcher

doi: 10.1038/nature18448

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Review

Searching for the rules that govern hadron construction p.487

Advances in meson spectroscopy can enhance our understanding of how composite objects emerge from the fundamental underlying theory of interacting quarks and gluons, quantum chromodynamics.

Matthew R. Shepherd, Jozef J. Dudek & Ryan E. Mitchell

doi: 10.1038/nature18011

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Articles

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain p.494

Two spider toxins are shown to target the Nav1.1 subtype of sodium channel specifically, shedding light on the role of these channels in mechanical pain signalling.

Jeremiah D. Osteen, Volker Herzig, John Gilchrist, Joshua J. Emrick, Chuchu Zhang, Xidao Wang, Joel Castro, Sonia Garcia-Caraballo, Luke Grundy, Grigori Y. Rychkov + et al.

doi: 10.1038/nature17976

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Defining the consequences of genetic variation on a proteome-wide scale p.500

The effect of natural genetic diversity on the proteome is characterized using an outbred mouse model with extensive variation; both transcripts and proteins from mouse livers are quantified to identify a large set of protein quantitative trait loci (pQTL), and mediation analysis identifies causal protein intermediates of distant pQTL.

Joel M. Chick, Steven C. Munger, Petr Simecek, Edward L. Huttlin, Kwangbom Choi, Daniel M. Gatti, Narayanan Raghupathy, Karen L. Svenson, Gary A. Churchill & Steven P. Gygi

doi: 10.1038/nature18270

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Crystal structure of the epithelial calcium channel TRPV6 p.506

The X-ray crystal structure of rat transient receptor potential channel TRPV6 at 3.25 Å resolution is reported, providing new insights into its assembly and calcium-selective permeation.

Kei Saotome, Appu K. Singh, Maria V. Yelshanskaya & Alexander I. Sobolevsky

doi: 10.1038/nature17975

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Letters

The first gravitational-wave source from the isolated evolution of two stars in the 40–100 solar mass range p.512

Numerical simulations of the formation of binary black holes provide a framework within which to interpret the recent detection of the first gravitational-wave source and to predict the properties of subsequent binary-black-hole gravitational-wave events; the calculations predict detections of about 1,000 black-hole mergers per year once gravitational-wave observatories reach full sensitivity.

Krzysztof Belczynski, Daniel E. Holz, Tomasz Bulik & Richard O’Shaughnessy

doi: 10.1038/nature18322

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Real-time dynamics of lattice gauge theories with a few-qubit quantum computer p.516

A digital quantum simulation of a lattice gauge theory is performed on a quantum computer that consists of a few trapped-ion qubits; the model simulated is the Schwinger mechanism, which describes the creation of electron–positron pairs from vacuum.

Esteban A. Martinez, Christine A. Muschik, Philipp Schindler, Daniel Nigg, Alexander Erhard, Markus Heyl, Philipp Hauke, Marcello Dalmonte, Thomas Monz, Peter Zoller + et al.

doi: 10.1038/nature18318

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Solid-state harmonics beyond the atomic limit p.520

A direct comparison of high harmonic generation in the solid and gas phases of Ar and Kr reveals higher harmonics in these rare-gas solids caused by strong interband couplings; evidence of recollisions implies that gas-phase techniques for attosecond pulse generation and orbital tomography could be adapted for solids.

Georges Ndabashimiye, Shambhu Ghimire, Mengxi Wu, Dana A. Browne, Kenneth J. Schafer, Mette B. Gaarde & David A. Reis

doi: 10.1038/nature17660

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Negative capacitance in multidomain ferroelectric superlattices p.524

Negative capacitance is observed in a model system of multidomain ferroelectric–dielectric superlattices; the multidomain state can increase the temperature range over which negative capacitance can be observed.

Pavlo Zubko, Jacek C. Wojdeł, Marios Hadjimichael, Stéphanie Fernandez-Pena, Anaïs Sené, Igor Luk’yanchuk, Jean-Marc Triscone & Jorge Íñiguez

doi: 10.1038/nature17659

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Controlled fragmentation of multimaterial fibres and films via polymer cold-drawing p.529

Cold-drawing of multimaterial fibres consisting of a brittle core embedded in a ductile polymer cladding results in controllable fragmentation of the core to produce uniformly sized rods parallel to the drawing direction for cylindrical geometries and narrow, parallel strips perpendicular to the drawing direction for flat geometries.

Soroush Shabahang, Guangming Tao, Joshua J. Kaufman, Yangyang Qiao, Lei Wei, Thomas Bouchenot, Ali P. Gordon, Yoel Fink, Yuanli Bai, Robert S. Hoy + et al.

doi: 10.1038/nature17980

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Abiological catalysis by artificial haem proteins containing noble metals in place of iron p.534

Replacing the iron atom in Fe-porphyrin IX proteins with a noble-metal atom enables the creation of enzymes that catalyse reactions not catalysed by native Fe-enzymes or other metalloenzymes; this approach could be used to generate other artificial enzymes that could catalyse a wide range of abiological transformations.

Hanna M. Key, Paweł Dydio, Douglas S. Clark & John F. Hartwig

doi: 10.1038/nature17968

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A complement–microglial axis drives synapse loss during virus-induced memory impairment p.538

People infected with West Nile virus often experience cognitive side effects including memory loss through unknown mechanisms; mice and humans infected with the virus experience a loss in hippocampal presynaptic terminals, which can be reversed by disrupting complement or microglia in mice.

Michael J. Vasek, Charise Garber, Denise Dorsey, Douglas M. Durrant, Bryan Bollman, Allison Soung, Jinsheng Yu, Carlos Perez-Torres, Arnaud Frouin, Daniel K. Wilton + et al.

doi: 10.1038/nature18283

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Hemi-fused structure mediates and controls fusion and fission in live cells p.548

Super-resolution imaging provides direct evidence in live cells that membrane fusion and fission are mediated through an intermediate hemi-fused structure, where fusion and calcium/dynamin-dependent fission mechanisms compete to determine the transition of the intermediate to fusion or fission.

Wei-Dong Zhao, Edaeni Hamid, Wonchul Shin, Peter J. Wen, Evan S. Krystofiak, Seth A. Villarreal, Hsueh-Cheng Chiang, Bechara Kachar & Ling-Gang Wu

doi: 10.1038/nature18598

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AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy p.553

An investigation into the nuclear events involved in autophagy regulation identifies the histone arginine methyltransferase CARM1 as a transcriptional co-activator of transcription factor TFEB; CARM1 levels are decreased by the SKP2-containing E3 ubiquitin ligase and increased during autophagy induction after nutrient starvation.

Hi-Jai R. Shin, Hyunkyung Kim, Sungryong Oh, Jun-Gi Lee, Minjung Kee, Hyun-Jeong Ko, Mi-Na Kweon, Kyoung-Jae Won & Sung Hee Baek

doi: 10.1038/nature18014

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Proteome-wide covalent ligand discovery in native biological systems p.570

Small molecules are powerful tools for investigating protein function, and can serve as leads for new therapeutics, but most human proteins lack known small-molecule ligands; here, a quantitative analysis of cysteine-reactive small-molecule fragments screened against thousands of proteins is reported.

Keriann M. Backus, Bruno E. Correia, Kenneth M. Lum, Stefano Forli, Benjamin D. Horning, Gonzalo E. González-Páez, Sandip Chatterjee, Bryan R. Lanning, John R. Teijaro, Arthur J. Olson + et al.

doi: 10.1038/nature18002

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