Volume 534 Number 7608

Editorials

Data sharing p.435

Pooling clinical details helps doctors to diagnose rare diseases — but more sharing is needed.

doi: 10.1038/534435b

Way of the dragon p.435

To boost its research quality and innovation, China must strengthen its scientific foundations and let researchers — not policymakers — set the agenda for innovation and discovery.

doi: 10.1038/534435a

At gunpoint p.436

The problem of gun violence in the United States must finally be addressed.

doi: 10.1038/534436a

News

News Features

Science in China p.451

A special issue looks at the country's astonishing scientific trajectory as it seeks to secure its spot among the leaders in innovation.

doi: 10.1038/534451a

Science stars of China p.456

From ancient DNA to neutrinos and neuroscience, top researchers in China are making big impacts — and raising their country’s standing in science.

doi: 10.1038/534456a

News & Views

Recipe for a black-hole merger p.478

The detection of a gravitational wave was a historic event that heralded a new phase of astronomy. A numerical model of the Universe now allows researchers to tell the story of the black-hole system that caused the wave. See Letter p.512

doi: 10.1038/534478a

Membrane kiss mediates hormone secretion p.479

Communication between cells relies on hormone release from secretory granules, but how these vesicles fuse with cell membranes is unclear. An imaging study provides in vivo evidence for a stable intermediate fusion step. See Letter p.548

doi: 10.1038/nature18446

Quantum simulation of fundamental physics p.480

Gauge theories underpin the standard model of particle physics, but are difficult to study using conventional computational methods. An experimental quantum system opens up fresh avenues of investigation. See Letter p.516

doi: 10.1038/534480a

Gene regulation in transition p.482

An in-depth analysis of a close relative of animals, Capsaspora owczarzaki, provides clues to the changes in gene regulation that occurred during the transition to multicellularity.

doi: 10.1038/nature18447

Synergy of a warm spring and dry summer p.483

An analysis suggests that high carbon uptake by US land ecosystems during the warm spring of 2012 offset the carbon loss that resulted from severe drought over the summer — and hints that the warm spring could have worsened the drought.

doi: 10.1038/nature18450

When sperm meets egg p.484

Sperm–egg binding is mediated by two cell-surface proteins. Structural analysis of these proteins separately and in complex provides insight into the recognition process and the subsequent sperm–egg fusion. See Letters p.562 & p.566

doi: 10.1038/nature18448

Review

Articles

Defining the consequences of genetic variation on a proteome-wide scale p.500

The effect of natural genetic diversity on the proteome is characterized using an outbred mouse model with extensive variation; both transcripts and proteins from mouse livers are quantified to identify a large set of protein quantitative trait loci (pQTL), and mediation analysis identifies causal protein intermediates of distant pQTL.

doi: 10.1038/nature18270

Letters

The first gravitational-wave source from the isolated evolution of two stars in the 40–100 solar mass range p.512

Numerical simulations of the formation of binary black holes provide a framework within which to interpret the recent detection of the first gravitational-wave source and to predict the properties of subsequent binary-black-hole gravitational-wave events; the calculations predict detections of about 1,000 black-hole mergers per year once gravitational-wave observatories reach full sensitivity.

doi: 10.1038/nature18322

Solid-state harmonics beyond the atomic limit p.520

A direct comparison of high harmonic generation in the solid and gas phases of Ar and Kr reveals higher harmonics in these rare-gas solids caused by strong interband couplings; evidence of recollisions implies that gas-phase techniques for attosecond pulse generation and orbital tomography could be adapted for solids.

doi: 10.1038/nature17660

Proteome-wide covalent ligand discovery in native biological systems p.570

Small molecules are powerful tools for investigating protein function, and can serve as leads for new therapeutics, but most human proteins lack known small-molecule ligands; here, a quantitative analysis of cysteine-reactive small-molecule fragments screened against thousands of proteins is reported.

doi: 10.1038/nature18002