네이처 컨텐츠


Siren call p.413

Now that gravitational waves have been discovered, it is time to put them to use.

doi: 10.1038/531413b


Cultural conundrum p.413

The Chinese government’s professed commitment to transparency and responsiveness has had a rocky start. That bodes ill for the desire to attract the best science brains from around the world.

doi: 10.1038/531413a


Power of the pen p.414

Scientists must unite to stop Turkey from removing the right to freedom of expression.

doi: 10.1038/531414a



News Features

The secret lives of jellyfish p.432

Long regarded as minor players in ocean ecology, jellyfish are actually important parts of the marine food web.

Garry Hamilton

doi: 10.1038/531432a


News & Views

Lost memories found p.450

Enhancing synaptic connections between neurons in the brain's hippocampus that are normally activated during memory formation rescues memory deficits in a mouse model of early Alzheimer's disease. See Letter p.508

Prerana Shrestha & Eric Klann

doi: 10.1038/nature17312


Dispersion explains declines p.451

Migratory birds are declining globally. A broad study of European migratory birds finds that species that disperse widely during the non-breeding season are less likely to be in decline than are species with more restricted dispersion.

Richard A. Fuller

doi: 10.1038/531451a


No double bond left behind p.453

Alkenyl halides are some of the most useful building blocks for synthesizing small organic molecules. A catalyst has now allowed their direct preparation from widely available alkenes using the cross-metathesis reaction. See Article p.459

David Sarlah

doi: 10.1038/531453a


Viral strategies at sea p.454

The finding that marine environments with high levels of host microbes have fewer viruses per host than when host abundance is low challenges a theory on the relative roles of lysogenic and lytic viral-survival strategies. See Article p.466

T. Frede Thingstad & Gunnar Bratbak

doi: 10.1038/nature17303


Signs of a wandering Moon p.455

The presence of ice at two positions on opposite sides of the Moon suggests that the satellite's orientation was once shifted away from its present spin axis — a finding that has implications for the Moon's volcanic history. See Letter p.480

Ian Garrick-Bethell

doi: 10.1038/531455a


Corruption corrupts p.456

A cross-cultural experiment involving thousands of people worldwide shows that the prevalence of rule violations in a society, such as tax evasion and fraudulent politics, is detrimental to individuals' intrinsic honesty. See Letter p.496

Shaul Shalvi

doi: 10.1038/nature17307



Direct synthesis of Z-alkenyl halides through catalytic cross-metathesis p.459

One shortcoming of olefin metathesis has been that acyclic alkenyl halides could not be generated efficiently and stereoselectively; but now halo-substituted molybdenum alkylidene species are shown to be able to participate in high-yielding olefin metathesis reactions that afford acyclic 1,2-disubstituted Z-alkenyl halides.

Ming Joo Koh, Thach T. Nguyen, Hanmo Zhang, Richard R. Schrock & Amir H. Hoveyda

doi: 10.1038/nature17396

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Lytic to temperate switching of viral communities p.466

An analysis of 24 coral reef viromes challenges the view that lytic phage are believed to predominate when the density of their hosts increase and shows instead that lysogeny is more important at high host densities; the authors also show that this model is consistent with predator–prey dynamics in a range of other ecosystems, such as animal-associated, sediment and soil systems.

B. Knowles, C. B. Silveira, B. A. Bailey, K. Barott, V. A. Cantu, A. G. Cobián-Güemes, F. H. Coutinho, E. A. Dinsdale, B. Felts, K. A. Furby + et al.

doi: 10.1038/nature17193

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Deletions linked to TP53 loss drive cancer through p53-independent mechanisms p.471

The loss of the TP53 gene is often involved in the development of human cancer; here, the deletion of other genes in the vicinity is shown also to contribute to cancer progression in a mouse model.

Yu Liu, Chong Chen, Zhengmin Xu, Claudio Scuoppo, Cory D. Rillahan, Jianjiong Gao, Barbara Spitzer, Benedikt Bosbach, Edward R. Kastenhuber, Timour Baslan + et al.

doi: 10.1038/nature17157

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Acceleration of petaelectronvolt protons in the Galactic Centre p.476

Deep γ-ray observations of the Galactic Centre with arcminute angular resolution show traces of petaelectronvolt protons within the central ten parsecs of our Galaxy; the accelerator of these particles could have provided a substantial contribution to Galactic cosmic rays in the past.

doi: 10.1038/nature17147

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Lunar true polar wander inferred from polar hydrogen p.480

Polar hydrogen deposits on the Moon provide evidence that its spin axis has shifted; analysis of the locations of these deposits and of the lunar figure suggests that the shift occurred as a result of changes in the Moon’s moments of inertia caused by a low-density thermal anomaly beneath the Procellarum region.

M. A. Siegler, R. S. Miller, J. T. Keane, M. Laneuville, D. A. Paige, I. Matsuyama, D. J. Lawrence, A. Crotts & M. J. Poston

doi: 10.1038/nature17166

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Modes of surface premelting in colloidal crystals composed of attractive particles p.485

Incomplete premelting at the edges of monolayer colloidal crystals is triggered by a bulk solid–solid phase transition and truncated by a mechanical instability that induces homogeneous bulk melting of the crystal; these observations challenge existing theories of two-dimensional melting.

Bo Li, Feng Wang, Di Zhou, Yi Peng, Ran Ni & Yilong Han

doi: 10.1038/nature16987

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On-surface synthesis of graphene nanoribbons with zigzag edge topology p.489

Synthesis of atomically precise zigzag edges in graphene nanoribbons is demonstrated using a bottom-up strategy based on surface-assisted arrangement and reaction of precursor monomers; these nanoribbons have edge-localized states with large energy splittings.

Pascal Ruffieux, Shiyong Wang, Bo Yang, Carlos Sánchez-Sánchez, Jia Liu, Thomas Dienel, Leopold Talirz, Prashant Shinde, Carlo A. Pignedoli, Daniele Passerone + et al.

doi: 10.1038/nature17151

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The past, present and future of African dust p.493

Variability in North African dust dispersal, which affects air quality and the amount of radiation reaching the ground, is captured by the wind patterns over the Sahara; climate models suggest a downward trend in dust concentration with increasing greenhouse gas emissions.

Amato T. Evan, Cyrille Flamant, Marco Gaetani & Françoise Guichard

doi: 10.1038/nature17149

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Intrinsic honesty and the prevalence of rule violations across societies p.496

To test whether there is a relationship between the level of national corruption and the intrinsic honesty of individuals, a behavioural test of the honesty of people from 23 countries was conducted; the authors found that high national scores on an index of rule-breaking are linked with reduced personal honesty.

Simon Gächter & Jonathan F. Schulz

doi: 10.1038/nature17160

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Nuclear DNA sequences from the Middle Pleistocene Sima de los Huesos hominins p.504

Nuclear DNA sequences from Middle Pleistocene Sima de los Huesos hominins show they were more closely related to Neanderthals than to Denisovans, and indicate a population divergence between Neanderthals and Denisovans that predates 430,000 years ago.

Matthias Meyer, Juan-Luis Arsuaga, Cesare de Filippo, Sarah Nagel, Ayinuer Aximu-Petri, Birgit Nickel, Ignacio Martínez, Ana Gracia, José María Bermúdez de Castro, Eudald Carbonell + et al.

doi: 10.1038/nature17405

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Visualization of immediate immune responses to pioneer metastatic cells in the lung p.513

Tracing the fate of circulating tumour cells by intravital two-photon lung imaging shows that tumours produce microparticles as they arrive and these migrate along the lung vasculature and are mostly taken up by interstitial myeloid cells, in a process that contributes to metastatic seeding; a minor subset of microparticles is engulfed by conventional dendritic cells, which are thought to contribute to the initiation of an anti-tumour immune response in lung-draining lymph nodes.

Mark B. Headley, Adriaan Bins, Alyssa Nip, Edward W. Roberts, Mark R. Looney, Audrey Gerard & Matthew F. Krummel

doi: 10.1038/nature16985

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Melanoma addiction to the long non-coding RNA SAMMSON p.518

A known oncogene, MITF, resides in a region of chromosome 3 that is amplified in melanomas and associated with poor prognosis; now, a long non-coding RNA gene, SAMMSON, is shown to also lie in this region, to also act as a melanoma-specific survival oncogene, and to be a promising therapeutic target for anti-melanoma therapy.

Eleonora Leucci, Roberto Vendramin, Marco Spinazzi, Patrick Laurette, Mark Fiers, Jasper Wouters, Enrico Radaelli, Sven Eyckerman, Carina Leonelli, Katrien Vanderheyden + et al.

doi: 10.1038/nature17161

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The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation p.523

The GCN2 kinase is shown to have a protective role in the regulation of intestinal inflammation during amino acid starvation in a mouse model of colitis.

Rajesh Ravindran, Jens Loebbermann, Helder I. Nakaya, Nooruddin Khan, Hualing Ma, Leonardo Gama, Deepa K. Machiah, Benton Lawson, Paul Hakimpour, Yi-chong Wang + et al.

doi: 10.1038/nature17186

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PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection p.528

The energetic burden of continuously concentrating solutes against gradients along the tubule may render the kidney especially vulnerable to ischaemia. Acute kidney injury (AKI) affects 3% of all hospitalized patients. Here we show that the mitochondrial biogenesis regulator, PGC1α, is a pivotal determinant of renal recovery from injury by regulating nicotinamide adenine dinucleotide (NAD) biosynthesis. Following renal ischaemia, Pgc1α−/− (also known as Ppargc1a−/−) mice develop local deficiency of the NAD precursor niacinamide (NAM, also known as nicotinamide), marked fat accumulation, and failure to re-establish normal function. Notably, exogenous NAM improves local NAD levels, fat accumulation, and renal function in post-ischaemic Pgc1α−/− mice. Inducible tubular transgenic mice (iNephPGC1α) recapitulate the effects of NAM supplementation, including more local NAD and less fat accumulation with better renal function after ischaemia. PGC1α coordinately upregulates the enzymes that synthesize NAD de novo from amino acids whereas PGC1α deficiency or AKI attenuates the de novo pathway. NAM enhances NAD via the enzyme NAMPT and augments production of the fat breakdown product β-hydroxybutyrate, leading to increased production of prostaglandin PGE2 (ref. 5), a secreted autacoid that maintains renal function. NAM treatment reverses established ischaemic AKI and also prevented AKI in an unrelated toxic model. Inhibition of β-hydroxybutyrate signalling or prostaglandin production similarly abolishes PGC1α-dependent renoprotection. Given the importance of mitochondrial health in ageing and the function of metabolically active organs, the results implicate NAM and NAD as key effectors for achieving PGC1α-dependent stress resistance.

Mei T. Tran, Zsuzsanna K. Zsengeller, Anders H. Berg, Eliyahu V. Khankin, Manoj K. Bhasin, Wondong Kim, Clary B. Clish, Isaac E. Stillman, S. Ananth Karumanchi, Eugene P. Rhee + et al.

doi: 10.1038/nature17184

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