Success against cancer need not deliver the Moon.
Environmental agencies must go much further in regulating aircraft emissions if they want to make a real difference.
Scientists should pay more heed to the varying effects of diet and environment on animal work.
Historic discovery of ripples in space-time meant ruling out the possibility of a fake signal.
Detection of ripples in space-time kicks off new era in physics.
Environmental factors lie behind many irreproducible rodent experiments.
ASAPbio meeting discusses the ins and outs of posting work online before peer review.
Scramble by researchers to monitor driving restrictions in Indian capital pays off.
Plan aims to decrease carbon dioxide produced by new aeroplanes.
An evolutionary burst 540 million years ago filled the seas with an astonishing diversity of animals. The trigger behind that revolution is finally coming into focus.
Astronomers are beginning to glimpse what exoplanets orbiting distant suns are actually like.
News & Views
The force exerted by light on an object has been used to pair photons with quantum units of mechanical vibration. This paves the way for mechanical oscillators to act as interfaces between photons and other quantum systems. See Letter p.313
Cross-cultural experiments find that belief in moralistic, knowledgeable and punishing gods promotes cooperation with strangers, supporting a role for religion in the expansion of human societies. See Letter p.327
It emerges that ice discharge from a major ice sheet did not increase rapidly at the end of the most recent ice age. The finding points to steady, not catastrophic, ice-sheet loss and sea-level rise on millennial timescales. See Letter p.322
The fission of organelles called mitochondria has now been linked to the stress-sensor protein AMPK. When activated by stress, this protein phosphorylates the mitochondrial receptor protein MFF, which recruits the fission machinery.
The discovery of sex-biased proliferation in the intestinal stem cells of fruit-fly midguts reveals that the organ's size is determined by a previously undefined, sex-specific molecular pathway. See Letter p.344
The genome sequence of the marine flowering plant eelgrass (Zostera marina) sheds light on how marine algae evolved into land plants before moving back to the sea. See Letter p.331
The peptidergic neuronal circuit controlling sigh generation has been identified as ~200 Nmb- or Grp-expressing neurons in the RTN/pFRG breathing control centre of the medulla that project to ~200 receptor-expressing neurons in the respiratory rhythm generator, the preBötzinger Complex.
A 3.7 Å resolution structure for the yeast U4/U6.U5 tri-snRNP, a complex involved in splicing, allows a better appreciation of the architecture of the tri-snRNP, and offers new functional insights into the activation of the spliceosome and the assembly of the catalytic core.
By comparing asteroid detections and a near-Earth-object model the deficit of objects near the Sun is shown to arise from the breakup of most asteroids, especially low-albedo ones, at distances of a few tens of solar radii from the Sun.
An analytical framework is proposed for a complex network to accurately predict its dynamic resilience and unveil the network characteristics that can enhance or diminish resilience.
Non-classically correlated pairs of single photons and phonons are generated and read out from a nanomechanical resonator, demonstrating that such resonators could be used for light–matter quantum interfaces.
Homogenous electrocatalytic water reduction with formation of dihydrogen is demonstrated with a trisaryloxide U(iii) complex, for which the catalytic cycle was elucidated and found to involve rare terminal U(iv)–OH and U(v)=O complexes.
Reconstruction of the activity of ice streams operating during the retreat of the Laurentide Ice Sheet reveals that the number of ice streams and their total discharge decreased as the total volume of the ice sheet decreased, suggesting that ice stream activity did not accelerate the collapse of the ice sheet.
Using economic games, the authors examine the role of religion in the persistence of human cooperation; individuals who claim that their gods are moralizing, punitive and knowledgeable about human affairs are more likely to play fairly towards geographically distant co-religionists.
Whole-genome sequencing of the seagrass Zostera, representing the first marine angiosperm genome to be fully sequenced, provides insight into the evolutionary changes associated with a transition to a marine environment in this angiosperm lineage.
An evolutionary trade-off of unprecedented genetic complexity in the glucose/galactose utilization regulatory pathway across several long-diverged species of Saccharomyces.
Generation of an epitope-tagged, functional Wnt3 knock-in allele, the signal produced by Paneth cells to regulate intestinal stem cells.
Reversible, cell-intrinsic mechanisms that depend on a new sex differentiation pathway act in adult somatic cells of the Drosophila intestine to govern sex-specific differences in organ size, plasticity during reproduction, and response to tumorigenic insults.
By investigating trafficking of autoreactive T cells into the CSF during experimental autoimmune encephalitis, the authors find that T cells enter the CSF from the leptomeninges, and that commuting between the leptomeninges and the CSF is regulated by integrin adhesive forces triggered by T-cell activation and/or chemokines.
NEK7, a member of the NIMA-related kinase family, is identified as a regulator of NLRP3 inflammasome oligomerization and activation; NEK7 functions downstream of potassium efflux in a manner that is independent of its kinase activity.
An unexpected octameric integrase architecture for the betaretrovirus mouse mammary tumour virus intasome.
A crystal structure of the octameric integrase from Rous sarcoma virus in complex with viral and target DNAs.