Volume 530 Number 7588

Editorials

The next steps on Zika p.5

With birth defects blamed on the virus now deemed a matter of international concern, researchers must work fast to assess the extent of the threat.

doi: 10.1038/530005a

Green growth p.6

US policymakers must set aside their divisions and give climate research a much-needed boost.

doi: 10.1038/530006a

Better together p.6

The European Union has its issues, but a Brexit could spell problems for science.

doi: 10.1038/530006b

News

News Features

News & Views

Photocatalysts in close-up p.36

The water-splitting reaction is a promising route to renewable energy. Catalytic hotspots, and the best sites for co-catalyst placement, have now been pinpointed in a water-splitting catalyst, guiding future catalyst design. See Letter p.77

doi: 10.1038/530036a

A stretch in time p.37

Plots of survival against time for nematode worms in different conditions can be superimposed by rescaling the time axis. This observation has far-reaching implications for our understanding of the nature of ageing. See Letter p.103

doi: 10.1038/nature16873

Disorder in the court p.38

The native structure of the protein α-synuclein, which is implicated in Parkinson's disease, is controversial. In-cell nuclear magnetic resonance now shows that it remains disordered when loaded into living cells. See Article p.45

doi: 10.1038/nature16871

Ultrashort light pulses shake atoms p.41

The response of electrons in atoms to ultrashort optical light pulses has been probed by measuring the ultraviolet light emitted by the atoms. This reveals that a finite time delay occurs before the response. See Letter p.66

doi: 10.1038/530041a

Fibroblasts for all seasons p.42

Connective-tissue cells known as fibroblasts display an increasing spectrum of functions. Different fibroblast subtypes are now shown to either promote or suppress inflammation-associated intestinal cancers.

doi: 10.1038/530042a

Articles

Structural disorder of monomeric α-synuclein persists in mammalian cells p.45

Atomic resolution in-cell NMR and EPR spectroscopy show that the human amyloid protein α-synuclein remains disordered within all mammalian cells tested, including neurons, and identifies which parts of the protein dynamically interact or remain shielded from the cytoplasm, thus counteracting aggregation under physiological cell conditions.

doi: 10.1038/nature16531

Persistent HIV-1 replication maintains the tissue reservoir during therapy p.51

By examining viral sequences in lymphoid tissue from three HIV-1-infected individuals receiving drug therapy, the authors find phylogenetic evidence for ongoing virus replication, suggesting that the antiretroviral drug concentration in the lymphoid tissue is insufficient to fully suppress the virus; using a mathematical model, they further explain why drug resistance does not necessarily arise as a result.

doi: 10.1038/nature16933

Active medulloblastoma enhancers reveal subgroup-specific cellular origins p.57

Genomic studies of the paediatric brain tumour medulloblastoma have revealed four clinically distinct molecular subgroups; here active gene regulatory elements in 28 primary medulloblastoma tissues are mapped to reveal differentially regulated enhancers across the different subgroups, allowing insights into the transcription factors that characterize subgroup divergence and the cellular origin of the poorly characterized Group 3 and 4 subgroups.

doi: 10.1038/nature16546

Letters

Bioresorbable silicon electronic sensors for the brain p.71

Electronic implants are often used in diagnosing and treating human illness, but permanent implants come with problems; here, devices are described that can sense temperature, pressure, pH or thermal characteristics, and—crucially—are fully resorbable by the body.

doi: 10.1038/nature16492

An essential receptor for adeno-associated virus infection p.108

An adeno-associated virus (AAV) receptor protein essential for AAV2 entry into cells is identified; AAV receptor binds directly to the virus, and its ablation renders a diverse range of mammalian cell types and mice resistant to infection by AAV of multiple serotypes.

doi: 10.1038/nature16465

Genome-wide nucleosome specificity and function of chromatin remodellers in ES cells p.113

Genome-wide binding profiles for eight different chromatin remodellers in mouse embryonic stem (ES) cells are determined at single nucleosome resolution; each remodeller binds at specific nucleosome positions relative to the start of genes, and the same remodeller acts as a positive or negative regulator of transcription depending on the promoter chromatin organization and epigenetic marking of the gene it binds.

doi: 10.1038/nature16505