네이처 컨텐츠

Editorials

Drugs on demand p.410

Controversy in Brazil over access to a purported cancer cure could set a harmful precedent.

doi: 10.1038/527410b

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Built on trust p.410

Written agreements between parties in research collaborations are not a sign of a lack of faith.

doi: 10.1038/527410a

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News

News Features

All together now p.425

After 25 years of negotiations, all countries are finally set to take steps to limit global warming. A special issue examines the path to the Paris climate summit, and the road beyond.

doi: 10.1038/527425a

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The fragile framework p.427

A Nature comic examines the 25-year quest for a climate treaty. Can nations unite to save Earth’s climate?

Richard Monastersky & Nick Sousanis

doi: 10.1038/527427a

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Is the 2 °C world a fantasy? p.436

Countries have pledged to limit global warming to 2 °C, and climate models say that is still possible. But only with heroic — and unlikely — efforts.

Jeff Tollefson

doi: 10.1038/527436a

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News & Views

Acorn worms in a nutshell p.448

The genome sequences of two members of the hemichordate group of marine invertebrates bring the evolution of their relatives, including vertebrates, into sharper focus. See Article p.459

Casey W. Dunn

doi: 10.1038/nature16315

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A receptor for subtle temperature changes p.449

The protein IR25a is best known for its role as an odour receptor in flies, but an analysis reveals that it also acts to synchronize the circadian clock by sensing small temperature fluctuations. See Letter p.516

François Rouyer & Abhishek Chatterjee

doi: 10.1038/nature16316

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Super-resolution ultrasound p.451

By infusing blood vessels with gas-filled microbubbles and using rapid ultrasound imaging to detect the bubbles, super-resolution imaging of an entire vessel system has been achieved in a rat brain. See Letter p.499

Ben Cox & Paul Beard

doi: 10.1038/527451a

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Transition loses its invasive edge p.452

Two studies provide evidence that epithelial tumour cells do not need to transition to a mesenchymal-cell state to form metastases, but that this process does contribute to drug resistance. See Article p.472 & Letter p.525

Shyamala Maheswaran & Daniel A. Haber

doi: 10.1038/nature16313

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Hidden reservoirs p.453

West Africa's Ebola epidemic continues to reveal surprises. Although the animal species that originally passed the virus to people remains a mystery, a virus reservoir and persistent disease have been identified in some human survivors.

Jonathan L. Heeney

doi: 10.1038/527453a

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The Moon's tilt for gold p.455

The Moon's current orbit is at odds with theories predicting that its early orbit was in Earth's equatorial plane. Simulations now suggest that its orbit was tilted by gravitational interactions with a few large bodies. See Letter p.492

Robin Canup

doi: 10.1038/527455a

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Assassins of eyesight p.456

A molecular cascade involving the transcription factor SIX6 and its target gene p16INK4a causes the death of neurons that link the eye to the brain. This discovery deepens our understanding of a common form of blindness, glaucoma.

Andrew D. Huberman & Rana N. El-Danaf

doi: 10.1038/527456a

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Articles

Hemichordate genomes and deuterostome origins OPEN p.459

Sequencing the genomes of two enteropneusts reveals complex genomic organization and developmental innovation in the ancestor of deuterostomes, a group of animals including echinoderms (starfish and their relatives) and chordates (which includes humans).

Oleg Simakov, Takeshi Kawashima, Ferdinand Marlétaz, Jerry Jenkins, Ryo Koyanagi, Therese Mitros, Kanako Hisata, Jessen Bredeson, Eiichi Shoguchi, Fuki Gyoja + et al.

doi: 10.1038/nature16150

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A perisinusoidal niche for extramedullary haematopoiesis in the spleen p.466

Haematopoietic stem cells normally reside in a bone marrow niche but they are recruited to the spleen after physiological stresses; here, endothelial cells and stromal cells around sinusoidal blood vessels of the spleen are shown to secrete key niche factors to support this process.

Christopher N. Inra, Bo O. Zhou, Melih Acar, Malea M. Murphy, James Richardson, Zhiyu Zhao & Sean J. Morrison

doi: 10.1038/nature15530

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Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance p.472

An epithelial-to-mesenchymal transition (EMT) lineage-tracing system in a mouse model of breast-to-lung metastasis reveals that although some cells undergo EMT in a primary epithelial tumour, the lung metastases mainly arise from cells that have not undergone EMT; in addition, cells that have undergone EMT appear more resistant to chemotherapy.

Kari R. Fischer, Anna Durrans, Sharrell Lee, Jianting Sheng, Fuhai Li, Stephen T. C. Wong, Hyejin Choi, Tina El Rayes, Seongho Ryu, Juliane Troeger + et al.

doi: 10.1038/nature15748

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Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65 p.477

Yeast-based screening identifies the benzodiazepine drug lorazepam as a non-selective positive allosteric modulator of the G-protein-coupled receptor (GPCR) GPR68; homology modelling and molecular docking of 3.1 million molecules found a new compound, ‘ogerin’, as a potent GPR68 modulator, which suppressed recall in fear conditioning in wild-type mice, and the general method of combining physical and structure-based screening may lead to the discovery of selective ligands for other GPCRs.

Xi-Ping Huang, Joel Karpiak, Wesley K. Kroeze, Hu Zhu, Xin Chen, Sheryl S. Moy, Kara A. Saddoris, Viktoriya D. Nikolova, Martilias S. Farrell, Sheng Wang + et al.

doi: 10.1038/nature15699

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Letters

Extremely metal-poor stars from the cosmic dawn in the bulge of the Milky Way p.484

The first stars and their immediate successors should be found today in the central regions (bulges) of galaxies; old, metal-poor stars have now been found in the Milky Way bulge, including one star with an iron abundance about 10,000 times lower than that of the Sun without noticeable carbon enhancement, making it possibly the oldest known star in the Galaxy.

L. M. Howes, A. R. Casey, M. Asplund, S. C. Keller, D. Yong, D. M. Nataf, R. Poleski, K. Lind, C. Kobayashi, C. I. Owen + et al.

doi: 10.1038/nature15747

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Ubiquitous time variability of integrated stellar populations p.488

The number of long-period variable stars in a stellar population is directly related to their lifetime, which is difficult to predict from first principles; here a time-dependent stellar population model is constructed that includes the effects of long-period variable stars, and is applied to the galaxy M87.

Charlie Conroy, Pieter G. van Dokkum & Jieun Choi

doi: 10.1038/nature15731

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Type-II Weyl semimetals p.495

A new type of topological semimetal is described, which contains so-called type-II Weyl fermions and has very different properties to standard Weyl semimetals, owing to the existence of an open Fermi surface rather than a point-like one in the vicinity of Weyl points; WTe2 is predicted to be one such semimetal.

Alexey A. Soluyanov, Dominik Gresch, Zhijun Wang, QuanSheng Wu, Matthias Troyer, Xi Dai & B. Andrei Bernevig

doi: 10.1038/nature15768

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Ultrafast ultrasound localization microscopy for deep super-resolution vascular imaging p.499

Conventional clinical ultrasound imaging has, at best, sub-millimetre-scale resolution, but now a new ultrasound technique is demonstrated that is based on fast tracking of transient signals from a sub-wavelength contrast agent and has sufficiently high resolution to map the microvasculature deep into organs.

Claudia Errico, Juliette Pierre, Sophie Pezet, Yann Desailly, Zsolt Lenkei, Olivier Couture & Mickael Tanter

doi: 10.1038/nature16066

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Extra adsorption and adsorbate superlattice formation in metal-organic frameworks p.503

Metal-organic frameworks (MOFs) have a high internal surface area and widely tunable composition, which make them useful for applications involving adsorption, such as hydrogen, methane or carbon dioxide storage. The selectivity and uptake capacity of the adsorption process are determined by interactions involving the adsorbates and their porous host materials. But, although the interactions of adsorbate molecules with the internal MOF surface and also amongst themselves within individual pores have been extensively studied, adsorbate–adsorbate interactions across pore walls have not been explored. Here we show that local strain in the MOF, induced by pore filling, can give rise to collective and long-range adsorbate–adsorbate interactions and the formation of adsorbate superlattices that extend beyond an original MOF unit cell. Specifically, we use in situ small-angle X-ray scattering to track and map the distribution and ordering of adsorbate molecules in five members of the mesoporous MOF-74 series along entire adsorption–desorption isotherms. We find in all cases that the capillary condensation that fills the pores gives rise to the formation of ‘extra adsorption domains’—that is, domains spanning several neighbouring pores, which have a higher adsorbate density than non-domain pores. In the case of one MOF, IRMOF-74-V-hex, these domains form a superlattice structure that is difficult to reconcile with the prevailing view of pore-filling as a stochastic process. The visualization of the adsorption process provided by our data, with clear evidence for initial adsorbate aggregation in distinct domains and ordering before an even distribution is finally reached, should help to improve our understanding of this process and may thereby improve our ability to exploit it practically.

Hae Sung Cho, Hexiang Deng, Keiichi Miyasaka, Zhiyue Dong, Minhyung Cho, Alexander V. Neimark, Jeung Ku Kang, Omar M. Yaghi & Osamu Terasaki

doi: 10.1038/nature15734

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Single-molecule sequencing of the desiccation-tolerant grass Oropetium thomaeum OPEN p.508

Oropetium thomaeum is a resurrection plant that can survive extreme water stress through desiccation to complete dryness, providing a model for drought tolerance; here, whole-genome sequencing and assembly of the Oropetium genome using single-molecule real-time sequencing is reported.

Robert VanBuren, Doug Bryant, Patrick P. Edger, Haibao Tang, Diane Burgess, Dinakar Challabathula, Kristi Spittle, Richard Hall, Jenny Gu, Eric Lyons + et al.

doi: 10.1038/nature15714

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Sweet and bitter taste in the brain of awake behaving animals p.512

Activation of the sweet and bitter cortical fields in awake mice evokes predetermined behavioural programs, independent of learning and experience, illustrating the hardwired and innate nature of the sense of taste.

Yueqing Peng, Sarah Gillis-Smith, Hao Jin, Dimitri Tränkner, Nicholas J. P. Ryba & Charles S. Zuker

doi: 10.1038/nature15763

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Drosophila Ionotropic Receptor 25a mediates circadian clock resetting by temperature p.516

A Drosophila chemosensory receptor, expressed in leg sensory neurons, is necessary for behavioural and molecular synchronization of the fly’s circadian clock to low-amplitude temperature cycles; this temperature-sensing pathway functions independently from the known temperature sensors of the fly’s antennae.

Chenghao Chen, Edgar Buhl, Min Xu, Vincent Croset, Johanna S. Rees, Kathryn S. Lilley, Richard Benton, James J. L. Hodge & Ralf Stanewsky

doi: 10.1038/nature16148

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Fungal pathogen uses sex pheromone receptor for chemotropic sensing of host plant signals p.521

Fungal pathogens reorient hyphal growth towards their plant hosts in response to chemical signals; here, directed growth of the plant pathogen Fusarium oxysporum towards the roots of the tomato plant is shown to be triggered by class III peroxidases secreted by the tomato plant, with the fungal response requiring a sex pheromone receptor.

David Turrà, Mennat El Ghalid, Federico Rossi & Antonio Di Pietro

doi: 10.1038/nature15516

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Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer p.525

Deletion of Twist or Snail, two key transcription factors that induce epithelial-to-mesenchymal transition in a mouse model of pancreatic ductal adenocarcinoma leads to an increase in cell proliferation, and a greater sensitivity to the chemotherapeutic agent gemcitabine, with no effect on invasion or metastasis.

Xiaofeng Zheng, Julienne L. Carstens, Jiha Kim, Matthew Scheible, Judith Kaye, Hikaru Sugimoto, Chia-Chin Wu, Valerie S. LeBleu & Raghu Kalluri

doi: 10.1038/nature16064

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Foreign DNA capture during CRISPR–Cas adaptive immunity p.535

The structure of the Cas1–Cas2 complex bound to a protospacer sequence illustrates how foreign DNA is captured and measured by bacterial proteins in preparation for integration into CRISPR loci.

James K. Nuñez, Lucas B. Harrington, Philip J. Kranzusch, Alan N. Engelman & Jennifer A. Doudna

doi: 10.1038/nature15760

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Endoperoxide formation by an α-ketoglutarate-dependent mononuclear non-haem iron enzyme p.539

Many peroxy-containing secondary metabolites have been isolated and shown to provide beneficial effects to human health. Yet, the mechanisms of most endoperoxide biosyntheses are not well understood. Although endoperoxides have been suggested as key reaction intermediates in several cases, the only well-characterized endoperoxide biosynthetic enzyme is prostaglandin H synthase, a haem-containing enzyme. Fumitremorgin B endoperoxidase (FtmOx1) from Aspergillus fumigatus is the first reported α-ketoglutarate-dependent mononuclear non-haem iron enzyme that can catalyse an endoperoxide formation reaction. To elucidate the mechanistic details for this unique chemical transformation, we report the X-ray crystal structures of FtmOx1 and the binary complexes it forms with either the co-substrate (α-ketoglutarate) or the substrate (fumitremorgin B). Uniquely, after α-ketoglutarate has bound to the mononuclear iron centre in a bidentate fashion, the remaining open site for oxygen binding and activation is shielded from the substrate or the solvent by a tyrosine residue (Y224). Upon replacing Y224 with alanine or phenylalanine, the FtmOx1 catalysis diverts from endoperoxide formation to the more commonly observed hydroxylation. Subsequent characterizations by a combination of stopped-flow optical absorption spectroscopy and freeze-quench electron paramagnetic resonance spectroscopy support the presence of transient radical species in FtmOx1 catalysis. Our results help to unravel the novel mechanism for this endoperoxide formation reaction.

Wupeng Yan, Heng Song, Fuhang Song, Yisong Guo, Cheng-Hsuan Wu, Ampon Sae Her, Yi Pu, Shu Wang, Nathchar Naowarojna, Andrew Weitz + et al.

doi: 10.1038/nature15519

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