The HIV epidemic can be stopped p.127

doi: 10.1038/523127a

A numbers game p.127

doi: 10.1038/523127b

Cloud cover p.128

doi: 10.1038/523128a

Night-time storm chasers stalk their prey on US Plains p.135

doi: 10.1038/523135a

European labs set sights on continent-wide computing cloud p.136

doi: 10.1038/523136a

Plant denizens get the big-science treatment p.137

doi: 10.1038/523137a

US vaccine researcher sentenced to prison for fraud p.138

doi: 10.1038/nature.2015.17660

Pluto fly-by: a graphical guide to the historic mission p.140

doi: 10.1038/523140a

The 24/7 search for killer quakes p.142

doi: 10.1038/523142a

How to beat HIV p.146

doi: 10.1038/523146a

Iron's voyage from the abyss p.160

doi: 10.1038/523160a

Diagnosis by extracellular vesicles p.161

doi: 10.1038/nature14626

Hidden impacts of logging p.163

doi: 10.1038/523163a

A twist in the tale of γ-ray bursts p.164

doi: 10.1038/523164b

How to build a microbial eye p.166

doi: 10.1038/nature14630

Another action of a thalidomide derivative p.167

doi: 10.1038/nature14628

Feedback in low-mass galaxies in the early Universe p.169

doi: 10.1038/nature14454

Glypican-1 identifies cancer exosomes and detects early pancreatic cancer p.177

doi: 10.1038/nature14581

Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS p.183

doi: 10.1038/nature14610

A very luminous magnetar-powered supernova associated with an ultra-long γ-ray burst p.189

A new class of ultra-long-duration (more than 10,000 seconds) γ-ray bursts has recently been suggested. They may originate in the explosion of stars with much larger radii than those producing normal long-duration γ-ray bursts or in the tidal disruption of a star. No clear supernova has yet been associated with an ultra-long-duration γ-ray burst. Here we report that a supernova (SN 2011kl) was associated with the ultra-long-duration γ-ray burst GRB 111209A, at a redshift z of 0.677. This supernova is more than three times more luminous than type Ic supernovae associated with long-duration γ-ray bursts, and its spectrum is distinctly different. The slope of the continuum resembles those of super-luminous supernovae, but extends further down into the rest-frame ultraviolet implying a low metal content. The light curve evolves much more rapidly than those of super-luminous supernovae. This combination of high luminosity and low metal-line opacity cannot be reconciled with typical type Ic supernovae, but can be reproduced by a model where extra energy is injected by a strongly magnetized neutron star (a magnetar), which has also been proposed as the explanation for super-luminous supernovae.

doi: 10.1038/nature14579

Global-scale coherence modulation of radiation-belt electron loss from plasmaspheric hiss p.193

doi: 10.1038/nature14515

Long-range energy transport in single supramolecular nanofibres at room temperature p.196

doi: 10.1038/nature14570

Basin-scale transport of hydrothermal dissolved metals across the South Pacific Ocean p.200

doi: 10.1038/nature14577

Eye-like ocelloids are built from different endosymbiotically acquired components p.204

doi: 10.1038/nature14593

Unusual biology across a group comprising more than 15% of domain Bacteria p.208

doi: 10.1038/nature14486

Human body epigenome maps reveal noncanonical DNA methylation variation OPEN p.212

doi: 10.1038/nature14465

Global circulation patterns of seasonal influenza viruses vary with antigenic drift p.217

doi: 10.1038/nature14460

Th17 cells transdifferentiate into regulatory T cells during resolution of inflammation p.221

doi: 10.1038/nature14452

Hypoxia fate mapping identifies cycling cardiomyocytes in the adult heart p.226

doi: 10.1038/nature14582

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity p.231

Melanoma treatment is being revolutionized by the development of effective immunotherapeutic approaches. These strategies include blockade of immune-inhibitory receptors on activated T cells; for example, using monoclonal antibodies against CTLA-4, PD-1, and PD-L1 (refs 3, 4, 5). However, only a subset of patients responds to these treatments, and data suggest that therapeutic benefit is preferentially achieved in patients with a pre-existing T-cell response against their tumour, as evidenced by a baseline CD8+ T-cell infiltration within the tumour microenvironment. Understanding the molecular mechanisms that underlie the presence or absence of a spontaneous anti-tumour T-cell response in subsets of cases, therefore, should enable the development of therapeutic solutions for patients lacking a T-cell infiltrate. Here we identify a melanoma-cell-intrinsic oncogenic pathway that contributes to a lack of T-cell infiltration in melanoma. Molecular analysis of human metastatic melanoma samples revealed a correlation between activation of the WNT/β-catenin signalling pathway and absence of a T-cell gene expression signature. Using autochthonous mouse melanoma models we identified the mechanism by which tumour-intrinsic active β-catenin signalling results in T-cell exclusion and resistance to anti-PD-L1/anti-CTLA-4 monoclonal antibody therapy. Specific oncogenic signals, therefore, can mediate cancer immune evasion and resistance to immunotherapies, pointing to new candidate targets for immune potentiation.

doi: 10.1038/nature14404

Cyclic di-GMP acts as a cell cycle oscillator to drive chromosome replication p.236

doi: 10.1038/nature14473

Condensin-driven remodelling of X chromosome topology during dosage compensation p.240

doi: 10.1038/nature14450