네이처 컨텐츠

Editorials

Undue burdens p.127

Proposed controls on foreign operations in China are a threat to scientific collaboration.

doi: 10.1038/522127b

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Sex and the law p.127

A report from South Africa on the science of human sexuality and its implications for policy-making brings African countries a step closer to confronting laws that criminalize homosexuality.

doi: 10.1038/522127a

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Tough targets p.128

Concrete goals set out by the G7 nations lay the groundwork for a climate accord.

doi: 10.1038/522128a

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News

News Features

News & Views

A master lock for deadly parasites p.158

An RNA-interference screen has identified the protein CD55, expressed on the surface of red blood cells, as an essential receptor for infection of the cells by the malaria parasite Plasmodium falciparum.

Wai-Hong Tham & Alexander T. Kennedy

doi: 10.1038/522158a

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Nuclear dilemma resolved p.159

After cell division, membranes become fused around the nucleus to encapsulate the cell's chromosomes. It emerges that this process is regulated by the ESCRT-III protein complex. See Letters p.231 & p.236

Brian Burke

doi: 10.1038/nature14527

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Bright future for hyperbolic chips p.160

The unusual properties of hyperbolic metamaterials, such as their ability to propagate light on the nanoscale without diffraction, have been realized in two-dimensional devices, heralding improved photonic circuits. See Letter p.192

Guy Bartal

doi: 10.1038/522160a

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The micronucleus gets its big break p.162

Extensive chromosomal rearrangement – chromothripsis – is seen in several cancers. Imaging and sequencing of single cells shows that this phenomenon can occur inside cellular anomalies known as micronuclei. See Article p.179

Kristin A. Knouse & Angelika Amon

doi: 10.1038/nature14528

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Timing is everything during deglaciations p.163

Links between various climate records for the North Atlantic Ocean and the Mediterranean Sea have helped to identify a potential mechanism that enhanced sea-level rise during the last interglacial time interval. See Letter p.197

Katharina Billups

doi: 10.1038/522163a

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Ancient DNA steps into the language debate p.164

Two studies of ancient human DNA reveal expansions of Bronze Age populations that shed light on the long-running debate about the origins and spread of Indo-European languages. See Article p.167 & Letter p.207

John Novembre

doi: 10.1038/522164a

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Articles

Population genomics of Bronze Age Eurasia p.167

An analysis of 101 ancient human genomes from the Bronze Age (3000–1000 ʙᴄ) reveals large-scale population migrations in Eurasia consistent with the spread of Indo-European languages; individuals frequently had light skin pigmentation but were not lactose tolerant.

Morten E. Allentoft, Martin Sikora, Karl-Göran Sjögren, Simon Rasmussen, Morten Rasmussen, Jesper Stenderup, Peter B. Damgaard, Hannes Schroeder, Torbjörn Ahlström, Lasse Vinner + et al.

doi: 10.1038/nature14507

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Cloning and variation of ground state intestinal stem cells p.173

Novel technology to rapidly clone patient-specific, ‘ground state’ stem cells of columnar epithelia reveals their proliferative potential, remarkably precise and origin-dependent lineage commitment as well as genomic stability, despite extensive culturing, thereby skirting limitations associated with pluripotent stem cells.

Xia Wang, Yusuke Yamamoto, Lane H. Wilson, Ting Zhang, Brooke E. Howitt, Melissa A. Farrow, Florian Kern, Gang Ning, Yue Hong, Chiea Chuen Khor + et al.

doi: 10.1038/nature14484

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Chromothripsis from DNA damage in micronuclei p.179

The mechanism for chromothripsis, “shattered” chromosomes that can be observed in cancer cells, is unknown; here, using live-cell imaging and single-cell sequencing, chromothripsis is shown to occur after a chromosome is isolated into a micronucleus, an abnormal nuclear structure.

Cheng-Zhong Zhang, Alexander Spektor, Hauke Cornils, Joshua M. Francis, Emily K. Jackson, Shiwei Liu, Matthew Meyerson & David Pellman

doi: 10.1038/nature14493

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Letters

Small particles dominate Saturn’s Phoebe ring to surprisingly large distances p.185

Infrared imaging reveals all of Saturn’s faint, outermost ring, showing that it is composed principally of small dust particles and suggesting that particle temperatures are increased because of the radiative inefficiency of the smallest grains.

Douglas P. Hamilton, Michael F. Skrutskie, Anne J. Verbiscer & Frank J. Masci

doi: 10.1038/nature14476

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Small-scale dynamo magnetism as the driver for heating the solar atmosphere p.188

A model of the heating of the quiet Sun, in which magnetic fields are generated by a subphotospheric fluid dynamo intrinsically connected to granulation, shows fields expanding into the chromosphere, where plasma is heated at the rate required to match observations by small-scale eruptions that release magnetic energy and drive sonic motions, while the corona is heated by the dissipation of Alfvén waves.

Tahar Amari, Jean-François Luciani & Jean-Jacques Aly

doi: 10.1038/nature14478

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Visible-frequency hyperbolic metasurface p.192

Visible-frequency hyperbolic metasurfaces defined on single-crystal silver exhibit negative refraction and diffraction-free propagation, as well as strong, dispersion-dependent spin–orbit coupling for propagating surface plasmon polaritons, with device performance greatly exceeding those of previous bulk metamaterial demonstrations.

Alexander A. High, Robert C. Devlin, Alan Dibos, Mark Polking, Dominik S. Wild, Janos Perczel, Nathalie P. de Leon, Mikhail D. Lukin & Hongkun Park

doi: 10.1038/nature14477

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Bipolar seesaw control on last interglacial sea level p.197

A synthesis of new and existing data allows Heinrich Stadial 11 (HS11), a prominent Northern Hemisphere cold event, to be linked to the timing of peak sea-level rise during glacial termination T-II, whereas rapid sea-level rise in T-I is shown to clearly post-date Heinrich Stadial 1, so fundamentally different mechanisms seem to be at work during glacial terminations.

G. Marino, E. J. Rohling, L. Rodríguez-Sanz, K. M. Grant, D. Heslop, A. P. Roberts, J. D. Stanford & J. Yu

doi: 10.1038/nature14499

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Experimental constraints on the electrical anisotropy of the lithosphere–asthenosphere system p.202

Electrical anisotropy measurements at high temperatures and quasi-hydrostatic pressures on previously deformed olivine plus melt samples show that electrical conductivity is much higher in the direction of deformation; this is confirmed with a layered electrical model of the asthenosphere and lithosphere that reproduces existing field data.

Anne Pommier, Kurt Leinenweber, David L. Kohlstedt, Chao Qi, Edward J. Garnero, Stephen J. Mackwell & James A. Tyburczy

doi: 10.1038/nature14502

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Massive migration from the steppe was a source for Indo-European languages in Europe p.207

A genome-wide analysis of 69 ancient Europeans reveals the history of population migrations around the time that Indo-European languages arose in Europe, when there was a large migration into Europe from the Eurasian steppe in the east (providing a genetic ancestry still present in Europeans today); these findings support a ‘steppe origin’ hypothesis for how some Indo-European languages arose.

Wolfgang Haak, Iosif Lazaridis, Nick Patterson, Nadin Rohland, Swapan Mallick, Bastien Llamas, Guido Brandt, Susanne Nordenfelt, Eadaoin Harney, Kristin Stewardson + et al.

doi: 10.1038/nature14317

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Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo p.216

Two drugs, miconazole and clobetasol, have functions that modulate differentiation of oligodendrocyte progenitor cells directly, enhance remyelination, and significantly reduce disease severity in mouse models of multiple sclerosis.

Fadi J. Najm, Mayur Madhavan, Anita Zaremba, Elizabeth Shick, Robert T. Karl, Daniel C. Factor, Tyler E. Miller, Zachary S. Nevin, Christopher Kantor, Alex Sargent + et al.

doi: 10.1038/nature14335

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Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells p.221

The human endogenous retrovirus HERVK is normally silenced, but here the surprising discovery is made that in early human embryo development it is expressed, producing retroviral-like particles.

Edward J. Grow, Ryan A. Flynn, Shawn L. Chavez, Nicholas L. Bayless, Mark Wossidlo, Daniel J. Wesche, Lance Martin, Carol B. Ware, Catherine A. Blish, Howard Y. Chang + et al.

doi: 10.1038/nature14308

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ESCRT-III controls nuclear envelope reformation p.236

The ESCRT-III complex is implicated in the reformation of the nuclear envelope; the CHMP2A component of ESCRT-III is directed to the forming nuclear envelope through classical ESCRT-assembly mechanisms, with the help of the p97 complex component UFD1, and provides an activity essential for nuclear envelope reformation.

Yolanda Olmos, Lorna Hodgson, Judith Mantell, Paul Verkade & Jeremy G. Carlton

doi: 10.1038/nature14503

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