Volume 521 Number 7552

Editorials

Publish or perish p.259

Universities should release reports to show what they are doing to tackle misconduct — and funders should help them to do so effectively.

doi: 10.1038/521259a

A patent problem p.259

Making lawsuits more risky for patent trolls is just one way to stop abuse of the system.

doi: 10.1038/521259b

The kill switch p.260

Brain researchers and social scientists are well placed to find out what makes humans murder.

doi: 10.1038/521260a

News

News Features

Blame it on the antibodies p.274

Antibodies are the workhorses of biological experiments, but they are littering the field with false findings. A few evangelists are pushing for change.

doi: 10.1038/521274a

News & Views

Tools go back in time p.294

The finding of 3.3-million-year-old stone flints, cores, hammers and anvils in Kenya suggests that the first stone tools were made by human ancestors that pre-dated the earliest known members of the genus Homo. See Article p.310

doi: 10.1038/521294a

Squeezed ions in two places at once p.295

Experiments on a trapped calcium ion have again exposed the strange nature of quantum phenomena, and could pave the way for sensitive techniques to explore the boundary between the quantum and classical worlds. See Letter p.336

doi: 10.1038/521295a

Asymmetric rejuvenation p.296

Organelles called mitochondria are asymmetrically apportioned to the daughters of dividing stem cells according to mitochondrial age. This finding sheds light on the mechanisms underlying asymmetric stem-cell division.

doi: 10.1038/521296a

Magnetic alloys break the rules p.298

A family of alloys has been discovered that undergoes unexpected changes of shape when magnetized. This strange behaviour might help in unravelling the mystery of a phenomenon called magnetic hysteresis. See Letter p.340

doi: 10.1038/521298a

Equilibrium established p.299

Pluripotent cells can produce all cell types in the body. It emerges that this state of potential is endowed by cues, including inhibition of Wnt signalling, that maintain a balance between diverse cellular outcomes. See Article p.316

doi: 10.1038/521299a

Splicing does the two-step p.300

An intricate recursive RNA splicing mechanism that removes especially long introns (non-coding sequences) from genes has been found to be evolutionarily conserved and more prevalent than previously thought. See Letters p.371 & p.376

doi: 10.1038/nature14524

Review

The crystallography of correlated disorder p.303

Although classical crystallography is insufficient to determine disordered structure in crystals, correlated disorder does nevertheless contain clear crystallographic signatures that map to the type of disorder, which we are learning to decipher.

doi: 10.1038/nature14453

Articles

Neurotransmitter and psychostimulant recognition by the dopamine transporter p.322

Here the X-ray crystal structures of the Drosophila dopamine transporter bound to dopamine, D-amphetamine, methamphetamine and cocaine are solved; these structures show how a neurotransmitter, small molecule stimulants and cocaine bind to a biogenic amine transporter, and are examples of how the ligand binding site of a neurotransmitter transporter can remodel itself to accommodate structurally unrelated small molecules that are different in shape, size and polarity or charge.

doi: 10.1038/nature14431

Letters

A strong ultraviolet pulse from a newborn type Ia supernova p.328

Observations of declining ultraviolet emission from a type Ia supernova within four days of the explosion are as expected if material ejected by the supernova collided with a companion star, supporting the single degenerate channel model of supernova progenitors.

doi: 10.1038/nature14440

No signature of ejecta interaction with a stellar companion in three type Ia supernovae p.332

The explosion of a type Ia supernova could be triggered either by accretion from a companion—which should be indicated by brightening caused by interaction of supernova ejecta with the companion—or by a merger with a white dwarf or other small star; here observations by the Kepler mission of three type Ia supernovae reveal no such brightening, leading to the conclusion that they were triggered by a merger.

doi: 10.1038/nature14455

Non-Joulian magnetostriction p.340

Typical ferromagnets elongate and contract anisotropically when placed in a magnetic field but conserve the overall volume, an effect known as Joule magnetostriction; here, a new effect is observed in Fe–Ga alloys—large non-volume-conserving or non-Joulian magnetostriction—which has not previously been observed in any magnet.

doi: 10.1038/nature14459

Lipid nanoparticle siRNA treatment of Ebola-virus-Makona-infected nonhuman primates p.362

Ebola-virus-targeting short interfering RNAs (siRNAs) encapsulated in lipid nanoparticles are adapted to the current outbreak strain of the virus, and the siRNA cocktail is shown to protect nonhuman primates fully when administered 3 days after challenge with the current West African Ebola virus isolate; upon viral sequence data availability, the drug can be adapted to the new virus and produced in as little as 8 weeks.

doi: 10.1038/nature14442

Recursive splicing in long vertebrate genes p.371

Highly conserved recursive splice sites are identified in vertebrates, particularly within long genes encoding proteins that are involved in neuronal development; analysis of the splicing mechanism reveals that such recursive splicing sites can be used to dictate different mRNA isoforms.

doi: 10.1038/nature14466