Volume 521 Number 7550

Editorials

Splice of life p.5

Researchers, bioethicists and regulators must contribute to transparent disscussions on the risks and ethics of editing human embryos.

doi: 10.1038/521005a

Dirty money p.6

The fossil-fuel divestment campaign raises important questions but offers few solutions.

doi: 10.1038/521006a

Greek cash grab p.6

Government’s decision to plunder university funds shows lack of respect for science.

doi: 10.1038/521006b

News

News Features

News & Views

Beauty varies with the light p.34

Experimental work on guppies suggests that variation in light between microhabitats is what makes females prefer different male signal combinations, thus explaining the evolution and persistence of colour variation in males.

doi: 10.1038/521034a

Antibodies regulate antitumour immunity p.35

Boosting the T cells that mediate anticancer immune responses is a therapeutic goal. But T cells do not work alone — B cells and the antibodies they produce can both trigger and suppress the response. See Letters p.94 & p.99

doi: 10.1038/nature14388

Nanoscale connections for brain-like circuits p.37

Tiny circuit elements called memristors have been used as connections in an artificial neural network – enabling the system to learn to recognize letters of the alphabet from imperfect images. See Letter p.61

doi: 10.1038/521037a

Tasteless pesticides affect bees in the field p.38

Two studies provide evidence that bees cannot taste or avoid neonicotinoid pesticides, and that exposure to treated crops affects reproduction in solitary bees as well as bumblebee colony growth and reproduction. See Letters p.74 & p.77

doi: 10.1038/nature14391

Dinosaur up in the air p.40

A new feathered dinosaur from China, belonging to an obscure and strange carnivorous group, bears a seemingly bony wrist structure that may have had a role in flight. See Letter p.70

doi: 10.1038/nature14392

Organic polymers form fuel from water p.41

Porous polymers have joined the ranks of light-activated catalysts that split water into hydrogen, a carbon-free alternative to fossil fuels. Their properties are easily tuned — a big plus for the development of practically useful catalysts.

doi: 10.1038/521041a

Articles

Sequential cancer mutations in cultured human intestinal stem cells p.43

Using the CRISPR/Cas9 system, up to four frequently occurring colorectal cancer mutations were introduced alone or in combination into stem cell organoids derived from human small intestinal or colon tissue, allowing an in-depth investigation of the contribution of these mutations to cancer progression.

doi: 10.1038/nature14415

Letters

Curtain eruptions from Enceladus’ south-polar terrain p.57

Observations of the south pole of the Saturnian moon Enceladus revealed large rifts in the terrain that were found to be the sources of the observed jets of water vapour; now it is shown that much of the eruptive activity can be explained by broad, curtain-like eruptions, many of which were probably misinterpreted previously as discrete jets.

doi: 10.1038/nature14368

The formation and fate of internal waves in the South China Sea p.65

Internal oceanic waves are subsurface gravity waves that can be enormous and travel thousands of kilometres before breaking but they are difficult to study; here observations of such waves in the South China Sea reveal their formation mechanism, extreme turbulence, relationship to the Kuroshio Current and energy budget.

doi: 10.1038/nature14399

Bees prefer foods containing neonicotinoid pesticides p.74

It has been suggested that the negative effects on bees of neonicotinoid pesticides could be averted in field conditions if they chose not to forage on treated nectar; here field-level neonicotinoid doses are used in laboratory experiments to show that honeybees and bumblebees do not avoid neonicotinoid-treated food and instead actually prefer it.

doi: 10.1038/nature14414

Immunosuppressive plasma cells impede T-cell-dependent immunogenic chemotherapy p.94

IgA plasmocytes are shown to promote resistance to the immunogenic chemotherapeutic oxaliplatin in prostate cancer mouse models by inhibiting activation of cytotoxic T cells; immunosuppressive plasma cells, which are also found in human-therapy-resistant prostate cancer, are generated in response to TGFβ, and their functionality depends on PD-L1 expression and IL-10 secretion.

doi: 10.1038/nature14395

Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity p.99

Naturally occurring tumour-binding IgG antibodies are shown to initiate the rejection of allogeneic tumours, whereby Fc-receptor-mediated uptake of tumour immune complexes into dendritic cells activates tumour-reactive T cells, and intra-tumoral injection of allogeneic IgG together with dendritic cell adjuvants induces systemic T-cell-mediated antitumour responses.

doi: 10.1038/nature14424