네이처 컨텐츠

Editorials

High ambition p.163

The European Space Agency can be proud of its comet mission— whatever happens.

doi: 10.1038/515163b

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News

Scientists cleared of quake deaths p.171

Appeals court says six scientists did not cause deaths in 2009 L'Aquila earthquake and cuts sentence of a government official.

Alison Abbott & Nicola Nosengo

doi: 10.1038/515171a

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Landing on a comet p.172

A graphical guide identifies the dangers ahead for the Philae probe.

Elizabeth Gibney

doi: 10.1038/515172a

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Edits to ethics code rankle p.174

Clinical-trial obligations introduced into the Helsinki declaration called too onerous by some.

Heidi Ledford

doi: 10.1038/515174a

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News Features

The great depression p.179

Depression causes more disability than any other disorder. A special issue explores how science can help.

doi: 10.1038/515179a

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If depression were cancer p.182

Research into depression has struggled, while studies of cancer have thrived — but the balance could be shifting.

Heidi Ledford

doi: 10.1038/515182a

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A change of mind p.185

Cognitive behavioural therapy is the best-studied form of psychotherapy. But researchers are still struggling to understand why it works.

Emily Anthes

doi: 10.1038/515185a

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News & Views

The best way forward p.200

Conventional behavioural mouse models of depression are often used to study the disorder, but cannot capture the full picture of the human disease. Here, scientists present two views about the best research strategies to adopt if treatments are to be improved.

Lisa M. Monteggia, Robert C. Malenka & Karl Deisseroth

doi: 10.1038/515200a

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Magnetic fields without magnetic fields p.202

Exquisite control of quantum systems has allowed researchers to connect reality to ideas of how an exotic form of particle transport known as the quantum Hall effect can occur in the absence of a magnetic field. See Letters p.237 & p.241

Jonathan Simon

doi: 10.1038/515202a

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Mystery of the horrible hands solved p.203

A pair of newly discovered 70-million-year-old fossils from Mongolia — including material previously lost to poaching — reveals the true nature of one of the most enigmatic dinosaur species, Deinocheirus mirificus. See Letter p.257

Thomas R. Holtz

doi: 10.1038/nature13930

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Electron mirages in an iron salt p.205

The detection of unusual 'mirage' energy bands in photoemission spectra of single-atom layers of iron selenide reveals the probable cause of high-temperature superconductivity in these artificial structures. See Letter p.245

Jan Zaanen

doi: 10.1038/515205a

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Building a bigger brain p.206

An innovative approach to analysing the functions and gene-expression profiles of neural stem cells in developing human and mouse brains sheds light on the differences — and similarities — between the two species. See Letter p.264

Forrest O. Gulden & Nenad Šestan

doi: 10.1038/515206a

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Towards unified vesicle endocytosis p.207

An ultrafast, temperature-dependent mode of endocytosis, a process that is required for neurons to repeatedly fire, challenges current thinking and brings an old model back into the spotlight. See Article p.228

Vladan Lučić

doi: 10.1038/nature13925

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Articles

Synaptic, transcriptional and chromatin genes disrupted in autism p.209

Whole-exome sequencing in a large autism study identifies over 100 autosomal genes that are likely to affect risk for the disorder; these genes, which show unusual evolutionary constraint against mutations, carry de novo loss-of-function mutations in over 5% of autistic subjects and many function in synaptic, transcriptional and chromatin-remodelling pathways.

Silvia De Rubeis, Xin He, Arthur P. Goldberg, Christopher S. Poultney, Kaitlin Samocha, A. Ercument Cicek, Yan Kou, Li Liu, Menachem Fromer, Susan Walker + et al.

doi: 10.1038/nature13772

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The contribution of de novo coding mutations to autism spectrum disorder p.216

Family-based exome sequencing in a large autism study has identified 27 high-confidence gene targets and accurately estimates the contribution of both de novo gene-disrupting and missense mutations to the incidence of simplex autism, with target genes in affected females overlapping those in males of lower but not higher IQ; targets also overlap known targets for intellectual disability and schizophrenia, and are enriched for chromatin modifiers, FMRP-associated genes and embryonically expressed genes.

Ivan Iossifov, Brian J. O’Roak, Stephan J. Sanders, Michael Ronemus, Niklas Krumm, Dan Levy, Holly A. Stessman, Kali T. Witherspoon, Laura Vives, Karynne E. Patterson + et al.

doi: 10.1038/nature13908

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Evolution of mosquito preference for humans linked to an odorant receptor p.222

The mosquito Aedes aegypti includes two subspecies, one of which shows a preference for biting humans, whereas the other prefers to bite non-human animals; genetic analysis reveals that changes in the mosquito odorant receptor Or4 contribute to the behavioural difference—in human-preferring mosquitoes, Or4 is more highly expressed and more sensitive to sulcatone, a compound present at high levels in human odour.

Carolyn S. McBride, Felix Baier, Aman B. Omondi, Sarabeth A. Spitzer, Joel Lutomiah, Rosemary Sang, Rickard Ignell & Leslie B. Vosshall

doi: 10.1038/nature13964

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Clathrin regenerates synaptic vesicles from endosomes p.228

Ultrastructural analysis of synaptic vesicle recycling reveals that clathrin is not required for the initial rapid step of vesicle recycling by ultrafast endocytosis at the plasma membrane and instead clathrin acts later at an endosome to regenerate synaptic vesicles; however, when ultrafast endocytosis does not occur (for example, in experiments at room temperature rather than physiological temperature), clathrin-mediated endocytosis does happen at the plasma membrane.

Shigeki Watanabe, Thorsten Trimbuch, Marcial Camacho-Pérez, Benjamin R. Rost, Bettina Brokowski, Berit Söhl-Kielczynski, Annegret Felies, M. Wayne Davis, Christian Rosenmund & Erik M. Jorgensen

doi: 10.1038/nature13846

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Letters

The expanding fireball of Nova Delphini 2013 p.234

High spatial resolution is needed to study the early development of a nova; here measurements of the angular size and radial velocity of Nova Delphini 2013 reveal early structures in the ejected material and a geometric distance to the nova of about 4.5 kiloparsecs from the Sun.

G. H. Schaefer, T. ten Brummelaar, D. R. Gies, C. D. Farrington, B. Kloppenborg, O. Chesneau, J. D. Monnier, S. T. Ridgway, N. Scott, I. Tallon-Bosc + et al.

doi: 10.1038/nature13834

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Observation of topological transitions in interacting quantum circuits p.241

Superconducting quantum circuits are used to directly observe and characterize topological phase transitions; this approach promises to be a powerful and general platform for characterizing topological phenomena in quantum systems.

P. Roushan, C. Neill, Yu Chen, M. Kolodrubetz, C. Quintana, N. Leung, M. Fang, R. Barends, B. Campbell, Z. Chen + et al.

doi: 10.1038/nature13891

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Interfacial mode coupling as the origin of the enhancement of Tc in FeSe films on SrTiO3 p.245

Films of iron selenide (FeSe) one unit cell thick grown on strontium titanate (SrTiO3 or STO) substrates have recently shown superconducting energy gaps opening at temperatures close to the boiling point of liquid nitrogen (77 kelvin), which is a record for the iron-based superconductors. The gap opening temperature usually sets the superconducting transition temperature Tc, as the gap signals the formation of Cooper pairs, the bound electron states responsible for superconductivity. To understand why Cooper pairs form at such high temperatures, we examine the role of the SrTiO3 substrate. Here we report high-resolution angle-resolved photoemission spectroscopy results that reveal an unexpected characteristic of the single-unit-cell FeSe/SrTiO3 system: shake-off bands suggesting the presence of bosonic modes, most probably oxygen optical phonons in SrTiO3 (refs 5, 6, 7), which couple to the FeSe electrons with only a small momentum transfer. Such interfacial coupling assists superconductivity in most channels, including those mediated by spin fluctuations. Our calculations suggest that this coupling is responsible for raising the superconducting gap opening temperature in single-unit-cell FeSe/SrTiO3.

J. J. Lee, F. T. Schmitt, R. G. Moore, S. Johnston, Y.-T. Cui, W. Li, M. Yi, Z. K. Liu, M. Hashimoto, Y. Zhang + et al.

doi: 10.1038/nature13894

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Subduction-driven recycling of continental margin lithosphere p.253

Seismic images of the subducted Atlantic slab under northeastern South America and the Alboran slab beneath the Gibraltar arc region show that subducting oceanic plates viscously entrain and remove the bottom of the continental thermal boundary layer from adjacent continental margins, driving surface tectonics and pre-conditioning the margins for further deformation.

A. Levander, M. J. Bezada, F. Niu, E. D. Humphreys, I. Palomeras, S. M. Thurner, J. Masy, M. Schmitz, J. Gallart, R. Carbonell + et al.

doi: 10.1038/nature13878

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Comparative population genomics in animals uncovers the determinants of genetic diversity p.261

Genome-wide DNA polymorphism analysis across 76 animal species reveals a strong effect of ecological strategies, and particularly parental investment, on species levels of genetic diversity.

J. Romiguier, P. Gayral, M. Ballenghien, A. Bernard, V. Cahais, A. Chenuil, Y. Chiari, R. Dernat, L. Duret, N. Faivre + et al.

doi: 10.1038/nature13685

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Radial glia require PDGFD–PDGFRβ signalling in human but not mouse neocortex p.264

Evolutionary expansion of the human neocortex underlies many of our unique mental abilities. This expansion has been attributed to the increased proliferative potential of radial glia (RG; neural stem cells) and their subventricular dispersion from the periventricular niche during neocortical development. Such adaptations may have evolved through gene expression changes in RG. However, whether or how RG gene expression varies between humans and other species is unknown. Here we show that the transcriptional profiles of human and mouse neocortical RG are broadly conserved during neurogenesis, yet diverge for specific signalling pathways. By analysing differential gene co-expression relationships between the species, we demonstrate that the growth factor PDGFD is specifically expressed by RG in human, but not mouse, corticogenesis. We also show that the expression domain of PDGFRβ, the cognate receptor for PDGFD, is evolutionarily divergent, with high expression in the germinal region of dorsal human neocortex but not in the mouse. Pharmacological inhibition of PDGFD–PDGFRβ signalling in slice culture prevents normal cell cycle progression of neocortical RG in human, but not mouse. Conversely, injection of recombinant PDGFD or ectopic expression of constitutively active PDGFRβ in developing mouse neocortex increases the proportion of RG and their subventricular dispersion. These findings highlight the requirement of PDGFD–PDGFRβ signalling for human neocortical development and suggest that local production of growth factors by RG supports the expanded germinal region and progenitor heterogeneity of species with large brains.

Jan H. Lui, Tomasz J. Nowakowski, Alex A. Pollen, Ashkan Javaherian, Arnold R. Kriegstein & Michael C. Oldham

doi: 10.1038/nature13973

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The participation of cortical amygdala in innate, odour-driven behaviour p.269

Innate behaviours are observed in naive animals without prior learning or experience, suggesting that the neural circuits that mediate these behaviours are genetically determined and stereotyped. The neural circuits that convey olfactory information from the sense organ to the cortical and subcortical olfactory centres have been anatomically defined, but the specific pathways responsible for innate responses to volatile odours have not been identified. Here we devise genetic strategies that demonstrate that a stereotyped neural circuit that transmits information from the olfactory bulb to cortical amygdala is necessary for innate aversive and appetitive behaviours. Moreover, we use the promoter of the activity-dependent gene arc to express the photosensitive ion channel, channelrhodopsin, in neurons of the cortical amygdala activated by odours that elicit innate behaviours. Optical activation of these neurons leads to appropriate behaviours that recapitulate the responses to innate odours. These data indicate that the cortical amygdala plays a critical role in generating innate odour-driven behaviours but do not preclude its participation in learned olfactory behaviours.

Cory M. Root, Christine A. Denny, René Hen & Richard Axel

doi: 10.1038/nature13897

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A three-dimensional human neural cell culture model of Alzheimer’s disease p.274

Early-onset familial Alzheimer’s disease mutations induce both amyloid-β and tau pathologies in differentiated human neural stem cells in 3D cultures.

Se Hoon Choi, Young Hye Kim, Matthias Hebisch, Christopher Sliwinski, Seungkyu Lee, Carla D’Avanzo, Hechao Chen, Basavaraj Hooli, Caroline Asselin, Julien Muffat + et al.

doi: 10.1038/nature13800

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Piezo1 integration of vascular architecture with physiological force p.279

The Piezo1 calcium-permeable channel is revealed to have a role in the vascular cellular response to shear stress; a mouse knockout reveals that this channel is also important for normal vascular development.

Jing Li, Bing Hou, Sarka Tumova, Katsuhiko Muraki, Alexander Bruns, Melanie J. Ludlow, Alicia Sedo, Adam J. Hyman, Lynn McKeown, Richard S. Young + et al.

doi: 10.1038/nature13701

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The complete structure of the large subunit of the mammalian mitochondrial ribosome p.283

The structure of the 39S large mitoribosome subunit is solved by cryo-electron microscopy at an impressive 3.4 Å resolution, revealing the location of 50 ribosomal proteins, the peptidyl transferase centre, the tRNAs within this active site, and the nascent peptide chain within the exit tunnel.

Basil J. Greber, Daniel Boehringer, Marc Leibundgut, Philipp Bieri, Alexander Leitner, Nikolaus Schmitz, Ruedi Aebersold & Nenad Ban

doi: 10.1038/nature13895

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Structural basis for the assembly of the Sxl–Unr translation regulatory complex p.287

The crystal structure of the RNA binding domains of Sxl and Unr with msl2 RNA shows that interwoven interactions establish cooperative assembly of the ternary complex, highlighting how binding of relatively general RNA binding domains to RNA can result in a unique and specific protein–RNA architecture.

Janosch Hennig, Cristina Militti, Grzegorz M. Popowicz, Iren Wang, Miriam Sonntag, Arie Geerlof, Frank Gabel, Fátima Gebauer & Michael Sattler

doi: 10.1038/nature13693

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