네이처 컨텐츠

Editorials

Call to action p.535

Time to ramp up science’s contribution to controlling the Ebola outbreak.

doi: 10.1038/514535b

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Pillars of reform p.535

The Chinese government’s planned overhaul of its core research-funding system is vital if the country is to achieve its potential on the global scientific stage.

doi: 10.1038/514535a

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Code share p.536

Papers in Nature journals should make computer code accessible where possible.

doi: 10.1038/514536a

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News

News Features

The top 100 papers p.550

Nature explores the most-cited research of all time. Richard Van Noorden, Brendan Maher & Regina Nuzzo

Richard Van Noorden, Brendan Maher & Regina Nuzzo

doi: 10.1038/514550a

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The Ebola questions p.554

Scientists know a lot about the virus that causes Ebola — but there are many puzzles that they have yet to solve.

Erika Check Hayden

doi: 10.1038/514554a

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News & Views

Ghost locus appears p.570

The sequences of two sponge genomes provide evidence that the ParaHox developmental genes are older than previously thought. This has implications for animal taxonomy and for developmental and evolutionary biology. See Letter p.620

James O. McInerney & Mary J. O'Connell

doi: 10.1038/514570a

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Secret ingredient exposed p.571

Astronomers have suspected for some time that magnetic fields are a key ingredient in the accretion of material that surrounds young stars. New observations have just begun to reveal these fields in action. See Letter p.597

Christopher M. Johns-Krull

doi: 10.1038/nature13932

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Enzyme–chromatin complex visualized p.572

The structure of an enzyme that is bound to a nucleosome — a protein complex around which DNA is wrapped — reveals how contacts between the two orient the enzyme so that it can modify a specific amino-acid residue. See Article p.591

Jürg Müller & Christoph W. Müller

doi: 10.1038/514572a

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Radicals promote magnetic gel assembly p.574

Engineering complex tissues requires high-throughput, three-dimensional patterning of materials and cells. A method to assemble small gel components using magnetic forces from encapsulated free radicals could be just the ticket.

Christopher B. Rodell & Jason A. Burdick

doi: 10.1038/514574a

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Cell plasticity helps hearts to repair p.575

Fibroblast cells are known as key players in the repair of damaged heart structures. New findings show that injury also induces fibroblasts to become endothelial cells, helping to mend damaged blood vessels. See Article p.585

Toru Miyake & Raghu Kalluri

doi: 10.1038/nature13928

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Starve a fever, feed the microbiota p.576

A study finds that the cells lining the gut are modified in response to systemic infection, increasing the host's tolerance to infection in a manner that is dependent on the microorganisms that inhabit the gut. See Letter p.638

Seth Rakoff-Nahoum & Laurie E. Comstock

doi: 10.1038/nature13756

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Articles

Three new Jurassic euharamiyidan species reinforce early divergence of mammals p.579

Three new euharamiyidan species from the Jurassic period of China are described, cementing the alliance with multituberculates and showing that the initial divergence between groups of extant mammals—monotremes on the one side, marsupials and placentals on the other—goes back to the Triassic period.

Shundong Bi, Yuanqing Wang, Jian Guan, Xia Sheng & Jin Meng

doi: 10.1038/nature13718

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Mesenchymal–endothelial transition contributes to cardiac neovascularization p.585

This study shows that cardiac injury induces cardiac fibroblasts to undergo mesenchymal–endothelial transition and acquire an endothelial-cell like fate, a process mediated, in part, by a p53-dependent mechanism — use of a small molecule activator of p53 increases mesenchymal–endothelial transition, leading to reduced scarring and better preservation of heart function.

Eric Ubil, Jinzhu Duan, Indulekha C. L. Pillai, Manuel Rosa-Garrido, Yong Wu, Francesca Bargiacchi, Yan Lu, Seta Stanbouly, Jie Huang, Mauricio Rojas + et al.

doi: 10.1038/nature13839

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Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome p.591

The crystal structure of the PRC1 ubiquitylation module bound to its nucleosome core substrate is determined, revealing how a histone-modifying enzyme achieves substrate specificity by recognizing nucleosome surfaces distinct from the site of catalysis, and uncovering a unique role for the ubiquitin E2 enzyme in substrate recognition.

Robert K. McGinty, Ryan C. Henrici & Song Tan

doi: 10.1038/nature13890

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Letters

Spatially resolved magnetic field structure in the disk of a T Tauri star p.597

Measurements of polarized 1.25-mm continuum emission from the accretion disk of the T Tauri star HL Tau show that the magnetic field inside the disk cannot be dominated by a vertical component, and that a purely toroidal field also does not fit the data; this suggests that the role of the magnetic field in the accretion of a T Tauri star is more complex than the current theoretical understanding.

Ian W. Stephens, Leslie W. Looney, Woojin Kwon, Manuel Fernández-López, A. Meredith Hughes, Lee G. Mundy, Richard M. Crutcher, Zhi-Yun Li & Ramprasad Rao

doi: 10.1038/nature13850

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Possible planet formation in the young, low-mass, multiple stellar system GG Tau A p.600

Investigation of the triple stellar system GG Tau A reveals gas fragments within the central cavity between the Keplerian outer ring orbiting the entire system and the stars themselves; gas flow from this outer ring appears capable of sustaining the inner disk surrounding component star GG Tau Aa beyond the accretion lifetime, leaving time for planet formation to occur.

Anne Dutrey, Emmanuel Di Folco, Stéphane Guilloteau, Yann Boehler, Jeff Bary, Tracy Beck, Hervé Beust, Edwige Chapillon, Fredéric Gueth, Jean-Marc Huré + et al.

doi: 10.1038/nature13822

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Quantum tomography of an electron p.603

Quantum tomography of individual electrons, which in principle yields complete knowledge of their quantum states, is demonstrated by initially preparing them in a well-controlled quantum state called a leviton.

T. Jullien, P. Roulleau, B. Roche, A. Cavanna, Y. Jin & D. C. Glattli

doi: 10.1038/nature13821

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Room-temperature magnetic order on zigzag edges of narrow graphene nanoribbons p.608

In graphene nanoribbons of ‘zigzag’ edge orientation, the edges host unpaired electron spins that couple to generate long-range magnetic order (switching from antiferromagnetic to ferromagnetic inter-edge configuration as the ribbon width increases) under ambient conditions, enhancing the prospects for graphene-based spintronic devices.

Gábor Zsolt Magda, Xiaozhan Jin, Imre Hagymási, Péter Vancsó, Zoltán Osváth, Péter Nemes-Incze, Chanyong Hwang, László P. Biró & Levente Tapasztó

doi: 10.1038/nature13831

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Stochastic transport through carbon nanotubes in lipid bilayers and live cell membranes p.612

Short carbon nanotubes spontaneously insert into lipid bilayers and live cell membranes to form channels with useful and tunable transport properties that make them a promising biomimetic nanopore platform for developing cell interfaces, studying nanofluidic transport in biological channels, and creating stochastic sensors.

Jia Geng, Kyunghoon Kim, Jianfei Zhang, Artur Escalada, Ramya Tunuguntla, Luis R. Comolli, Frances I. Allen, Anna V. Shnyrova, Kang Rae Cho, Dayannara Munoz + et al.

doi: 10.1038/nature13817

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Centennial-scale changes in the global carbon cycle during the last deglaciation p.616

Carbon dioxide and methane records from a West Antarctic ice core show that although gradual variations in the concentration of atmospheric carbon dioxide during the last glacial termination are linked to changes in Antarctic temperature, the concentration underwent three abrupt, centennial-scale changes related to sudden climate changes in the Northern Hemisphere.

Shaun A. Marcott, Thomas K. Bauska, Christo Buizert, Eric J. Steig, Julia L. Rosen, Kurt M. Cuffey, T. J. Fudge, Jeffery P. Severinghaus, Jinho Ahn, Michael L. Kalk + et al.

doi: 10.1038/nature13799

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Calcisponges have a ParaHox gene and dynamic expression of dispersed NK homeobox genes p.620

A study of the genomes of calcisponges shows that they contain at least one ParaHox gene, adding weight to the ‘ghost locus’ hypothesis that Hox and ParaHox genes were present in the earliest animal ancestor, but subsequently lost in some sponge lineages.

Sofia A. V. Fortunato, Marcin Adamski, Olivia Mendivil Ramos, Sven Leininger, Jing Liu, David E. K. Ferrier & Maja Adamska

doi: 10.1038/nature13881

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Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function p.628

KRAS mutations are a driver event of pancreatic ductal adenocarcinoma; here, a subpopulation of dormant tumour cells, relying on oxidative phosphorylation for survival, is shown to be responsible for tumour relapse after treatment targeting the KRAS pathway.

Andrea Viale, Piergiorgio Pettazzoni, Costas A. Lyssiotis, Haoqiang Ying, Nora Sánchez, Matteo Marchesini, Alessandro Carugo, Tessa Green, Sahil Seth, Virginia Giuliani + et al.

doi: 10.1038/nature13611

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Rapid fucosylation of intestinal epithelium sustains host–commensal symbiosis in sickness p.638

Systemic exposure to Toll-like receptor (TLR) ligands during sickness is shown to induce fucosylation of the small intestine in mice; some of the fucose is shed into the intestinal lumen, where it provides nourishment for the microbiota.

Joseph M. Pickard, Corinne F. Maurice, Melissa A. Kinnebrew, Michael C. Abt, Dominik Schenten, Tatyana V. Golovkina, Said R. Bogatyrev, Rustem F. Ismagilov, Eric G. Pamer, Peter J. Turnbaugh + et al.

doi: 10.1038/nature13823

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Enhanced neonatal Fc receptor function improves protection against primate SHIV infection p.642

A mutation in VRC01, a broadly neutralizing, HIV-1-specific antibody, confers enhanced binding to the neonatal Fc receptor, increasing the antibody half-life in the serum and localization in mucosal tissues, where it provides superior protection against rectal simian HIV-1 infection in macaques.

Sung-Youl Ko, Amarendra Pegu, Rebecca S. Rudicell, Zhi-yong Yang, M. Gordon Joyce, Xuejun Chen, Keyun Wang, Saran Bao, Thomas D. Kraemer, Timo Rath + et al.

doi: 10.1038/nature13612

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Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C p.646

Simultaneous disruption of two different protein–protein interactions within the (APC/C–Cdc20)–substrate complex can synergistically inhibit APC/C-dependent proteolysis and mitotic exit.

Katharine L. Sackton, Nevena Dimova, Xing Zeng, Wei Tian, Mengmeng Zhang, Timothy B. Sackton, Johnathan Meaders, Kathleen L. Pfaff, Frederic Sigoillot, Hongtao Yu + et al.

doi: 10.1038/nature13660

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Transcriptional interference by antisense RNA is required for circadian clock function p.650

The transcriptions of frq sense and antisense RNAs are mutually inhibitory and form a double negative feedback loop required for robust and sustained circadian rhythmicity: antisense transcription inhibits sense expression by causing chromatin modifications and premature transcription termination.

Zhihong Xue, Qiaohong Ye, Simon R. Anson, Jichen Yang, Guanghua Xiao, David Kowbel, N. Louise Glass, Susan K. Crosthwaite & Yi Liu

doi: 10.1038/nature13671

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