Volume 514 Issue 7524


Call to action p.535

Time to ramp up science’s contribution to controlling the Ebola outbreak.

doi: 10.1038/514535b

Pillars of reform p.535

The Chinese government’s planned overhaul of its core research-funding system is vital if the country is to achieve its potential on the global scientific stage.

doi: 10.1038/514535a

Code share p.536

Papers in Nature journals should make computer code accessible where possible.

doi: 10.1038/514536a


News Features

The top 100 papers p.550

Nature explores the most-cited research of all time. Richard Van Noorden, Brendan Maher & Regina Nuzzo

doi: 10.1038/514550a

The Ebola questions p.554

Scientists know a lot about the virus that causes Ebola — but there are many puzzles that they have yet to solve.

doi: 10.1038/514554a

News & Views

Ghost locus appears p.570

The sequences of two sponge genomes provide evidence that the ParaHox developmental genes are older than previously thought. This has implications for animal taxonomy and for developmental and evolutionary biology. See Letter p.620

doi: 10.1038/514570a

Secret ingredient exposed p.571

Astronomers have suspected for some time that magnetic fields are a key ingredient in the accretion of material that surrounds young stars. New observations have just begun to reveal these fields in action. See Letter p.597

doi: 10.1038/nature13932

Enzyme–chromatin complex visualized p.572

The structure of an enzyme that is bound to a nucleosome — a protein complex around which DNA is wrapped — reveals how contacts between the two orient the enzyme so that it can modify a specific amino-acid residue. See Article p.591

doi: 10.1038/514572a

Radicals promote magnetic gel assembly p.574

Engineering complex tissues requires high-throughput, three-dimensional patterning of materials and cells. A method to assemble small gel components using magnetic forces from encapsulated free radicals could be just the ticket.

doi: 10.1038/514574a

Cell plasticity helps hearts to repair p.575

Fibroblast cells are known as key players in the repair of damaged heart structures. New findings show that injury also induces fibroblasts to become endothelial cells, helping to mend damaged blood vessels. See Article p.585

doi: 10.1038/nature13928

Starve a fever, feed the microbiota p.576

A study finds that the cells lining the gut are modified in response to systemic infection, increasing the host's tolerance to infection in a manner that is dependent on the microorganisms that inhabit the gut. See Letter p.638

doi: 10.1038/nature13756


Mesenchymal–endothelial transition contributes to cardiac neovascularization p.585

This study shows that cardiac injury induces cardiac fibroblasts to undergo mesenchymal–endothelial transition and acquire an endothelial-cell like fate, a process mediated, in part, by a p53-dependent mechanism — use of a small molecule activator of p53 increases mesenchymal–endothelial transition, leading to reduced scarring and better preservation of heart function.

doi: 10.1038/nature13839

Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome p.591

The crystal structure of the PRC1 ubiquitylation module bound to its nucleosome core substrate is determined, revealing how a histone-modifying enzyme achieves substrate specificity by recognizing nucleosome surfaces distinct from the site of catalysis, and uncovering a unique role for the ubiquitin E2 enzyme in substrate recognition.

doi: 10.1038/nature13890


Spatially resolved magnetic field structure in the disk of a T Tauri star p.597

Measurements of polarized 1.25-mm continuum emission from the accretion disk of the T Tauri star HL Tau show that the magnetic field inside the disk cannot be dominated by a vertical component, and that a purely toroidal field also does not fit the data; this suggests that the role of the magnetic field in the accretion of a T Tauri star is more complex than the current theoretical understanding.

doi: 10.1038/nature13850

Possible planet formation in the young, low-mass, multiple stellar system GG Tau A p.600

Investigation of the triple stellar system GG Tau A reveals gas fragments within the central cavity between the Keplerian outer ring orbiting the entire system and the stars themselves; gas flow from this outer ring appears capable of sustaining the inner disk surrounding component star GG Tau Aa beyond the accretion lifetime, leaving time for planet formation to occur.

doi: 10.1038/nature13822

Quantum tomography of an electron p.603

Quantum tomography of individual electrons, which in principle yields complete knowledge of their quantum states, is demonstrated by initially preparing them in a well-controlled quantum state called a leviton.

doi: 10.1038/nature13821

Room-temperature magnetic order on zigzag edges of narrow graphene nanoribbons p.608

In graphene nanoribbons of ‘zigzag’ edge orientation, the edges host unpaired electron spins that couple to generate long-range magnetic order (switching from antiferromagnetic to ferromagnetic inter-edge configuration as the ribbon width increases) under ambient conditions, enhancing the prospects for graphene-based spintronic devices.

doi: 10.1038/nature13831

Centennial-scale changes in the global carbon cycle during the last deglaciation p.616

Carbon dioxide and methane records from a West Antarctic ice core show that although gradual variations in the concentration of atmospheric carbon dioxide during the last glacial termination are linked to changes in Antarctic temperature, the concentration underwent three abrupt, centennial-scale changes related to sudden climate changes in the Northern Hemisphere.

doi: 10.1038/nature13799