Volume 514 Number 7520

Editorials

Warming up p.5

Prospects for international agreement on combating climate change look brighter.

doi: 10.1038/514005b

BRAIN gain p.6

A mixture of focus and innovation is the way forward for big neuroscience.

doi: 10.1038/514006a

News

News Features

To catch a cosmic ray p.20

The Pierre Auger Observatory in Argentina has spent almost ten years looking for the source of ultra-high-energy cosmic rays — but to no avail. Now the observatory faces an uncertain future.

doi: 10.1038/514020a

Extreme living p.24

After humans arrived in South America, they quickly spread into some of its most remote corners.

doi: 10.1038/514024a

News & Views

The plumbing of Greenland's ice p.38

Observations of the water pressure in drilled boreholes and natural moulins on the Greenland Ice Sheet show how its underlying plumbing system controls ice motion during the course of the summer melt season. See Letter p.80

doi: 10.1038/514038a

Making the cut p.39

Analysis of the first step in repairing double-stranded-DNA breaks reveals that the Mre11 enzyme makes a DNA nick at a point separate from the break ends, creating an entry site for further processing by exonuclease enzymes. See Letter p.122

doi: 10.1038/nature13751

Not just a storm in a teacup p.40

The cloud that emerged above the south pole of Saturn's moon Titan in 2012 has been found to consist of hydrogen cyanide particles. This unexpected result prompts fresh thinking about the atmosphere of this satellite. See Letter p.65

doi: 10.1038/514040a

Ebola therapy protects severely ill monkeys p.41

A blend of three monoclonal antibodies has completely protected monkeys against a lethal dose of Ebola virus. Unlike other post-infection therapies, the treatment works even at advanced stages of the disease. See Article p.47

doi: 10.1038/nature13746

The age of the quasars p.43

An infrared census of accreting supermassive black holes across a wide range of cosmic times indicates that the canonical understanding of how these luminous objects form and evolve may need to be adjusted.

doi: 10.1038/514043a

An integrated view of the skin microbiome p.44

An analysis of the combined genomes of microorganisms inhabiting human skin demonstrates how these communities vary between individuals and across body sites, and paves the way to understanding their functions. See Article p.59

doi: 10.1038/514044a

Articles

Reversion of advanced Ebola virus disease in nonhuman primates with ZMapp p.47

A new treatment, containing an optimized cocktail of three monoclonal antibodies against Ebola virus, provided full protection and disease reversal in rhesus monkeys when given under conditions in which controls succumbed by day 8; this new therapy may be a good candidate for treating Ebola virus infection in human patients.

doi: 10.1038/nature13777

Biogeography and individuality shape function in the human skin metagenome p.59

Previous work has shown that human skin is home to a rich and varied microbiota; here a metagenomic approach for samples from physiologically diverse body sites illuminates that the skin microbiota, including bacterial, fungal and viral members, is shaped by the local biogeography and yet marked by strong individuality.

doi: 10.1038/nature13786

Letters

HCN ice in Titan’s high-altitude southern polar cloud p.65

The cloud that appeared above the south pole of Saturn’s satellite Titan in early 2012 is found to be composed of micrometre-sized particles of frozen hydrogen cyanide, indicating a dramatic cooling of Titan’s atmosphere to temperatures about 100 degrees less than predicted by atmospheric circulation models.

doi: 10.1038/nature13789

Sae2 promotes dsDNA endonuclease activity within Mre11–Rad50–Xrs2 to resect DNA breaks p.122

The MRX complex, required for double-strand break (DSB) repair by homologous recombination, has 3′ to 5′ exonuclease activity, but homologous recombination at a DSB uses a 3′-tailed molecule, which requires resection of the 5′ strand; here it is shown that in yeast, Sae2 nuclease promotes MRX to make an initial endonucleolytic cut on the 5′ strand that may allow MRX to digest the 5′ strand back to the end in a 3′ to 5′ fashion.

doi: 10.1038/nature13771