네이처 컨텐츠

Editorials

Fishy business p.507

Delays in approving genetically engineered salmon may be a taste of worse to come.

doi: 10.1038/511507b

전문

Safety doesn’t happen by accident p.507

To create a strong biosafety culture, information on mishaps involving deadly pathogens must be reported and shared fully and transparently.

doi: 10.1038/511507a

전문

News

Biosafety controls come under fire p.515

Experts call for a stronger safety culture at secure sites after incidents involving anthrax and flu in a US laboratory.

Declan Butler

doi: 10.1038/511515a

전문

Contamination hits cell work p.518

Mycoplasma infestations are widespread and costing laboratories millions of dollars in lost research.

Ewen Callaway

doi: 10.1038/511518a

전문

News Features

Rivers on the run p.521

As the United States destroys its old dams, species are streaming back into the unfettered rivers.

Richard A. Lovett

doi: 10.1038/511521a

전문

Written in blood p.524

DNA circulating in the bloodstream could guide cancer treatment — if researchers can work out how best to use it.

Ed Yong

doi: 10.1038/511524a

전문

News & Views

Causes and effects of Antarctic ice p.536

Some 34 million years ago, there was a rapid growth of ice on Antarctica. A modelling study indicates that the ultimate cause of this glaciation was a decrease in the concentration of atmospheric carbon dioxide. See Letter p.574

Dan Lunt

doi: 10.1038/511536a

전문

The mixed blessing of interferon p.537

A study in monkeys finds that treatment with the protein interferon protects against simian immunodeficiency virus, but that prolonged interferon administration exacerbates the chronic stage of the infection. See Letter p.601

Amalio Telenti

doi: 10.1038/nature13517

전문

The path most travelled p.538

Continuous tracking of the random trajectories of a superconducting quantum system as it evolves between two selected initial and final states has allowed researchers to determine the most probable path of the system. See Letter p.570

Adrian Lupascu

doi: 10.1038/511538a

전문

Cellular memory erased in human embryos p.540

Two analyses of human eggs, sperm and early-stage embryos reveal a pronounced loss of DNA methylation — a molecular modification that affects gene transcription — after fertilization. See Letters p.606 & p.611

Wolf Reik & Gavin Kelsey

doi: 10.1038/nature13648

전문

Protein-export pathway illuminated p.541

Two studies provide evidence that the protein complex PTEX is needed for export of malaria-parasite proteins into the cytoplasm of infected cells, and that such export is essential for parasite survival. See Letters p.587 & p.592

Sanjay A. Desai & Louis H. Miller

doi: 10.1038/nature13646

전문

Articles

Comprehensive molecular profiling of lung adenocarcinoma OPEN p.543

An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

doi: 10.1038/nature13385

전문 |PDF

Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain p.557

An X-ray structure is presented for metabotropic glutamate receptor 5, a class C G-protein-coupled glutamate receptor linked to fragile X syndrome and neurological disorders; this study provides insights into the protein’s mechanism of action.

Andrew S. Doré, Krzysztof Okrasa, Jayesh C. Patel, Maria Serrano-Vega, Kirstie Bennett, Robert M. Cooke, James C. Errey, Ali Jazayeri, Samir Khan, Ben Tehan + et al.

doi: 10.1038/nature13396

전문 |PDF

Letters

Velocity anti-correlation of diametrically opposed galaxy satellites in the low-redshift Universe p.563

Measurements of the velocities of pairs of diametrically opposed satellite galaxies of host galaxies in the local Universe show that satellite pairs out to a distance of 150 kiloparsecs from their hosts are anti-correlated in their velocities and that galaxies in the larger-scale environment are strongly clumped along the axis joining the inner satellite pair.

doi: 10.1038/nature13481

전문 |PDF

Misaligned protoplanetary disks in a young binary star system p.567

Observations show that one or both of the protoplanetary disks in the young binary system HK Tauri are significantly inclined to the binary orbital plane, demonstrating that the necessary conditions exist for the misalignment-driven mechanisms thought to produce the unusual orbits of some extrasolar planets.

Eric L. N. Jensen & Rachel Akeson

doi: 10.1038/nature13521

전문 |PDF

Mapping the optimal route between two quantum states p.570

Reconstruction of the quantum trajectories of a superconducting circuit that evolves under the competing influences of continuous weak measurement and Rabi drive makes it possible to deduce the most probable path through quantum state space.

S. J. Weber, A. Chantasri, J. Dressel, A. N. Jordan, K. W. Murch & I. Siddiqi

doi: 10.1038/nature13559

전문 |PDF

Widespread mixing and burial of Earth’s Hadean crust by asteroid impacts p.578

A new bombardment model of the early Earth, calibrated with existing lunar and terrestrial data, shows that the Earth’s surface would have been widely reprocessed by impacts through mixing and burial by impact-generated melt; the model may also explain the age distribution of ancient zircons and the absence of early terrestrial rocks.

doi: 10.1038/nature13539

전문 |PDF

PTEX is an essential nexus for protein export in malaria parasites p.587

This paper demonstrates that a protein complex known as PTEX translocates all malaria parasite proteins destined for export into the cytosol of their host red blood cell.

Brendan Elsworth, Kathryn Matthews, Catherine Q. Nie, Ming Kalanon, Sarah C. Charnaud, Paul R. Sanders, Scott A. Chisholm, Natalie A. Counihan, Philip J. Shaw, Paco Pino + et al.

doi: 10.1038/nature13555

전문 |PDF

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes p.592

Plasmodium parasites, the causative agent of malaria, infect and remodel red blood cells by exporting hundreds of proteins into the red blood cell cytosol, a topological conundrum given that the parasite resides in a compartment known as the parasitophorous vacuole; here a dihydrofolate-reductase-based destabilization domain approach is used to inactivate HSP101, part of the Plasmodium translocon of exported proteins, and to demonstrate that it is required for the secretion of all classes of exported Plasmodium proteins.

Josh R. Beck, Vasant Muralidharan, Anna Oksman & Daniel E. Goldberg

doi: 10.1038/nature13574

전문 |PDF

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression p.601

The timing of type I interferon signalling determines the disease course of SIV infection.

Netanya G. Sandler, Steven E. Bosinger, Jacob D. Estes, Richard T. R. Zhu, Gregory K. Tharp, Eli Boritz, Doron Levin, Sathi Wijeyesinghe, Krystelle Nganou Makamdop, Gregory Q. del Prete + et al.

doi: 10.1038/nature13554

전문 |PDF

The DNA methylation landscape of human early embryos p.606

Base-resolution maps of DNA methylation in human gametes and early embryos offer novel insights into human methylation dynamics and the functional relationship between DNA methylation and gene expression.

Hongshan Guo, Ping Zhu, Liying Yan, Rong Li, Boqiang Hu, Ying Lian, Jie Yan, Xiulian Ren, Shengli Lin, Junsheng Li + et al.

doi: 10.1038/nature13544

전문 |PDF

DNA methylation dynamics of the human preimplantation embryo p.611

Genome-scale DNA methylation maps over early human embryogenesis and embryonic stem cell derivation provide insights into shared and unique modes of regulation when compared to the mouse model, including relationships to gene expression, transposable element activity, and maternal-specific methylation.

Zachary D. Smith, Michelle M. Chan, Kathryn C. Humm, Rahul Karnik, Shila Mekhoubad, Aviv Regev, Kevin Eggan & Alexander Meissner

doi: 10.1038/nature13581

전문 |PDF