Volume 511 Issue 7511


Safety doesn’t happen by accident p.507

To create a strong biosafety culture, information on mishaps involving deadly pathogens must be reported and shared fully and transparently.

doi: 10.1038/511507a

Fishy business p.507

Delays in approving genetically engineered salmon may be a taste of worse to come.

doi: 10.1038/511507b


News Features

Rivers on the run p.521

As the United States destroys its old dams, species are streaming back into the unfettered rivers.

doi: 10.1038/511521a

Written in blood p.524

DNA circulating in the bloodstream could guide cancer treatment — if researchers can work out how best to use it.

doi: 10.1038/511524a

News & Views

Causes and effects of Antarctic ice p.536

Some 34 million years ago, there was a rapid growth of ice on Antarctica. A modelling study indicates that the ultimate cause of this glaciation was a decrease in the concentration of atmospheric carbon dioxide. See Letter p.574

doi: 10.1038/511536a

The mixed blessing of interferon p.537

A study in monkeys finds that treatment with the protein interferon protects against simian immunodeficiency virus, but that prolonged interferon administration exacerbates the chronic stage of the infection. See Letter p.601

doi: 10.1038/nature13517

The path most travelled p.538

Continuous tracking of the random trajectories of a superconducting quantum system as it evolves between two selected initial and final states has allowed researchers to determine the most probable path of the system. See Letter p.570

doi: 10.1038/511538a

Cellular memory erased in human embryos p.540

Two analyses of human eggs, sperm and early-stage embryos reveal a pronounced loss of DNA methylation — a molecular modification that affects gene transcription — after fertilization. See Letters p.606 & p.611

doi: 10.1038/nature13648

Protein-export pathway illuminated p.541

Two studies provide evidence that the protein complex PTEX is needed for export of malaria-parasite proteins into the cytoplasm of infected cells, and that such export is essential for parasite survival. See Letters p.587 & p.592

doi: 10.1038/nature13646


Comprehensive molecular profiling of lung adenocarcinoma OPEN p.543

An integrated transcriptome, genome, methylome and proteome analysis of over 200 lung adenocarcinomas reveals high rates of somatic mutations, 18 statistically significantly mutated genes including RIT1 and MGA, splicing changes, and alterations in MAPK and PI(3)K pathway activity.

doi: 10.1038/nature13385


Velocity anti-correlation of diametrically opposed galaxy satellites in the low-redshift Universe p.563

Measurements of the velocities of pairs of diametrically opposed satellite galaxies of host galaxies in the local Universe show that satellite pairs out to a distance of 150 kiloparsecs from their hosts are anti-correlated in their velocities and that galaxies in the larger-scale environment are strongly clumped along the axis joining the inner satellite pair.

doi: 10.1038/nature13481

Misaligned protoplanetary disks in a young binary star system p.567

Observations show that one or both of the protoplanetary disks in the young binary system HK Tauri are significantly inclined to the binary orbital plane, demonstrating that the necessary conditions exist for the misalignment-driven mechanisms thought to produce the unusual orbits of some extrasolar planets.

doi: 10.1038/nature13521

Mapping the optimal route between two quantum states p.570

Reconstruction of the quantum trajectories of a superconducting circuit that evolves under the competing influences of continuous weak measurement and Rabi drive makes it possible to deduce the most probable path through quantum state space.

doi: 10.1038/nature13559

Widespread mixing and burial of Earth’s Hadean crust by asteroid impacts p.578

A new bombardment model of the early Earth, calibrated with existing lunar and terrestrial data, shows that the Earth’s surface would have been widely reprocessed by impacts through mixing and burial by impact-generated melt; the model may also explain the age distribution of ancient zircons and the absence of early terrestrial rocks.

doi: 10.1038/nature13539

PTEX component HSP101 mediates export of diverse malaria effectors into host erythrocytes p.592

Plasmodium parasites, the causative agent of malaria, infect and remodel red blood cells by exporting hundreds of proteins into the red blood cell cytosol, a topological conundrum given that the parasite resides in a compartment known as the parasitophorous vacuole; here a dihydrofolate-reductase-based destabilization domain approach is used to inactivate HSP101, part of the Plasmodium translocon of exported proteins, and to demonstrate that it is required for the secretion of all classes of exported Plasmodium proteins.

doi: 10.1038/nature13574

DNA methylation dynamics of the human preimplantation embryo p.611

Genome-scale DNA methylation maps over early human embryogenesis and embryonic stem cell derivation provide insights into shared and unique modes of regulation when compared to the mouse model, including relationships to gene expression, transposable element activity, and maternal-specific methylation.

doi: 10.1038/nature13581