False positives p.7
A correlation between error rate and success undermines promise of stem-cell trials.doi: 10.1038/509007b
Volume 509 Issue 7498
리서치 하이라이트
표지 기사： 부드러운 사지 움직임을 위해 필요한 척추 감각 피드백에 대한 시냅스 전 억제
매우 높은 단백질 합성 조절 비율이 요구되는 조혈모 세포
V1V2 부위에 대한 HIV 중화 항체 개발
매우 빠른 속도로 자전하고 있는 것으로 밝혀진 태양계 외부 행성 픽토리스 b
식도암 세포에서 특이적으로 발현되는 돌연변이 유전자 확인
헌팅턴 무도병에서 신경 퇴행에 직접 관여하는 시스타티오닌 분해 효소
간기에 있는2세포 생쥐 배아의 세포질에 의한 핵 재프로그램화
정량적 프로테오믹스를 통해서 새롭게 밝혀진 페리틴의 오토파고좀 전달을 매개하는 카고 수용체 NCOA4
RIG-I에 의한 유비퀴틴 유도 항 바이러스 신호 전달 활성화의 구조적 기반 분석
항 혈전 약물 타깃이 되는 P2Y12 수용체 구조 분석
컨텐츠
Editorials
No magic fix for carbon p.7
Carbon capture and storage projects promise to make a dent in global emissions — but only as part of a broader programme of technology deployment and economic incentives.doi: 10.1038/509007a
Agency for change p.8
Japan’s proposed reforms to science monitoring are welcome but long overdue.doi: 10.1038/509008a
News
Doubts over heart stem-cell therapy p.15
Study queries early-phase trials of heart-disease treatment.doi: 10.1038/509015a
US biodefence facilities ramp up p.16
Government effort to produce vaccines on demand raises questions about cost and strategy.doi: 10.1038/509016a
Basic science finds corporate refuge p.18
As many older companies move away from fundamental research, young technology firms are picking up the slack.doi: 10.1038/509018a
Two plants to put ‘clean coal’ to test p.20
Large-scale carbon-capture projects set to go live this year.doi: 10.1038/509020a
News Features
Smallpox watch p.22
Frozen mummies and envelopes of scabs could contain remnants of one of history's most prolific killers.doi: 10.1038/509022a
News & Views
Drought in the Congo Basin p.36
A remote-sensing analysis of tropical forests in the Congo Basin that are experiencing chronic drought reveals consistent patterns of reduced vegetation greenness, increased temperatures and decreased water storage. See Letter p.86doi: 10.1038/nature13330
Bright electron twisters p.37
A new holographic method has been used to convert ordinary electron beams into helical beams. These beams show promise in applications such as the spectroscopic analysis of materials with intrinsic handedness and nanoparticle manipulation.doi: 10.1038/509037a
Feedback throttled down for smooth moves p.38
A group of regulatory neurons in the spinal cord has been found to reduce sensory feedback to muscles in mice. Removal of these neurons leads to repetitive limb oscillations during reaching. See Article p.43doi: 10.1038/509038a
Making the Earth move p.40
Controversy exists over the roles of water and melt in the ductile layer of the mantle beneath Earth's surface plates. New data support models in which small amounts of melting occur in the uppermost part of this region. See Letter p.81doi: 10.1038/509040a
A new spin on exoplanets p.41
Spectroscopic observations of a young exoplanet have allowed its spin velocity to be directly measured. Its fast spin is in accord with the extrapolation of the known trend in spin velocity as a function of planet mass. See Letter p.63doi: 10.1038/509041a
Articles
Presynaptic inhibition of spinal sensory feedback ensures smooth movement p.43
A population of spinal interneurons that form axo–axonic connections with the terminals of proprioceptive afferents are shown to mediate presynaptic inhibition; their ablation elicits harmonic oscillations during goal-directed forelimb movements, which can be modelled as the consequence of an increase in sensory feedback gain.doi: 10.1038/nature13276
Haematopoietic stem cells require a highly regulated protein synthesis rate p.49
Haematopoietic stem cells (HSCs) have a lower rate of protein synthesis in vivo than most other haematopoietic cells, and both increases and decreases in the rate of protein synthesis impair HSC function, demonstrating that HSC maintenance—and hence, cellular homeostasis—requires the rate of protein synthesis to be highly regulated.doi: 10.1038/nature13035
Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies p.55
A longitudinal study of an individual patient developing neutralizing antibodies against HIV-1 (targeting the V1V2 region of gp120) reveals how such neutralizing antibodies develop and evolve over time, providing important insights relevant to vaccine development.doi: 10.1038/nature13036
Letters
Fast spin of the young extrasolar planet β Pictoris b p.63
The spin of a planet arises from the accretion of angular momentum during its formation
doi: 10.1038/nature13253
Molecular photons interfaced with alkali atoms p.66
Single organic dye molecules have high-flux, narrow-bandwidth single-photon emission and can be spectrally matched to the transitions of atoms acting as a quantum memory, making them promising for use in quantum information and communication schemes.doi: 10.1038/nature13191
Spontaneous transfer of chirality in an atropisomerically enriched two-axis system p.71
An enantioselective reaction involving a molecule with two axes of stereochemical consequence produces four stereoisomers, and rather than racemizing as the system approaches equilibrium, one of the diastereomeric pairs drifts spontaneously to a higher enantiomeric ratio.doi: 10.1038/nature13189
North Atlantic forcing of tropical Indian Ocean climate p.76
New sea surface temperature and oxygen isotope records, combined with climate modelling experiments, show that slowdowns of the Atlantic meridional overturning circulation during Heinrich stadials and the Younger Dryas stadial affected the tropical Indian Ocean hydroclimate through changes to the Hadley circulation.doi: 10.1038/nature13196
Electrical conductivity during incipient melting in the oceanic low-velocity zone p.81
Determination of the electrical conductivity of carbon-dioxide- and water-rich melts, which are typically produced at the onset of mantle melting, shows that incipient melts can trigger the high electrical conductivities found in oceanic regions of the asthenosphere.doi: 10.1038/nature13245
Widespread decline of Congo rainforest greenness in the past decade p.86
The long-term drying trend in central African rainforests might help to explain satellite-detected large-scale vegetation browning in the Congolese forests.doi: 10.1038/nature13265
Identification of genomic alterations in oesophageal squamous cell cancer p.91
Using whole-genome and whole-exome sequencing, this study identifies eight significantly mutated genes in oesophageal squamous cell cancer, including two genes, ADAM29 and FAM135B, not previously associated with this cancer type.doi: 10.1038/nature13176
Cystathionine γ-lyase deficiency mediates neurodegeneration in Huntington's disease p.96
Huntington’s disease is an autosomal dominant disease associated with a mutation in the gene encoding huntingtin (Htt) leading to expanded polyglutamine repeats of mutant Htt (mHtt) that elicit oxidative stress, neurotoxicity, and motor and behavioural changes
doi: 10.1038/nature13136
Nuclear reprogramming by interphase cytoplasm of two-cell mouse embryos p.101
Reprogramming after somatic cell nuclear transfer had been thought to be dependent on the recipient cytoplasm being arrested at the metaphase stage, but here interphase two-cell mouse embryos are shown to support successful reprogramming and generation of embryonic stem cells or cloned mice.doi: 10.1038/nature13134
Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy p.105
Through a quantitative proteomics analysis, a cohort of proteins is identified that associate with autophagosomes, among them a new cargo receptor called NCOA4 that, in response to iron deprivation, targets ferritin to autophagosomes and thereby releases iron.doi: 10.1038/nature13148
Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I p.110
RIG-I protein recognizes viral duplex RNA with a 5′-triphosphate group, activating innate immune responses; a crystal structure of its tetrameric CARD signalling domain reveals that non-covalently linked ubiquitin chains stabilize the tetramer in a ‘lock-washer’ structure that serves as a signalling platform for the recruitment and activation of MAVS.doi: 10.1038/nature13140
Structure of the human P2Y12 receptor in complex with an antithrombotic drug p.115
The X-ray crystal structure of the human P2Y12 receptor, which regulates platelet activation and thrombus formation, is solved in complex with an antithrombotic drug, providing insights for the development of new drugs.doi: 10.1038/nature13083
Agonist-bound structure of the human P2Y12 receptor p.119
An X-ray structure of human P2Y12 receptor, a clinical drug target for platelet aggregation inhibitors, is presented in complex with an agonist, providing insight into the δ-group of class A G-protein-coupled receptors.doi: 10.1038/nature13288
