네이처 컨텐츠

Editorials

Preventive therapy p.147

Stem-cell trials must be made easier, so that treatments can be based on real data.

doi: 10.1038/494147b

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A deal on the horizon p.147

Leaders have finally thrashed out the European Union budget for the next seven years. But how much money will go to research is yet to be confirmed.

doi: 10.1038/494147a

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Damage control p.148

Planning for extreme events must incorporate not just infrastructure but societal preparedness.

doi: 10.1038/494148a

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News

News Features

Stem cells in Texas: Cowboy culture p.166

By offering unproven therapies, a Texas biotechnology firm has sparked a bitter debate about how stem cells should be regulated.

David Cyranoski

doi: 10.1038/494166a

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News & Views

Neuroscience: To go or not to go p.178

A study shows that, rather than sequentially starting and stopping a movement, two parallel pathways involving neurons in the brain's basal ganglia seem to work in tandem to accomplish the complex task of motion. See Letter p.238

D. James Surmeier

doi: 10.1038/nature11856

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Asymmetric synthesis: Relay catalysis at a boron centre p.179

A boron complex catalyses the addition of allyl groups — hydrocarbon motifs — to 'activated imines' in a relay-like process, generating synthetically useful compounds as single mirror-image isomers. See Letter p.216

Valer Jeso & Glenn C. Micalizio

doi: 10.1038/494179a

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Cell biology: Beneficial lessons from viruses p.181

To thwart the antimicrobial responses of their hosts, pathogens have evolved diverse mechanisms, including autophagy. Knowledge of such mechanisms has now led to a pro-autophagy peptide that may be of therapeutic value. See Article p.201

Adolfo García-Sastre

doi: 10.1038/nature11947

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Earth science: All rise for the case of the missing magma p.182

A detailed geological analysis of a ridge in the Indian Ocean suggests that compositional variations in Earth's mantle have a surprisingly crucial role in the uplift of a bathymetric bulge along the ridge. See Article p.195

John Maclennan

doi: 10.1038/nature11950

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Review

Molecular signatures of G-protein-coupled receptors p.185

A systematic investigation of high-resolution G-protein-coupled receptor (GPCR) structures uncovers a conserved inter-helical network of non-covalent contacts that defines the GPCR fold, and provides insights into the molecular determinants of different GPCR conformations.

A. J. Venkatakrishnan, Xavier Deupi, Guillaume Lebon, Christopher G. Tate, Gebhard F. Schertler & M. Madan Babu

doi: 10.1038/nature11896

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Articles

Thin crust as evidence for depleted mantle supporting the Marion Rise p.195

The global ridge system is dominated by oceanic rises reflecting large variations in axial depth associated with mantle hotspots. The little-studied Marion Rise is as large as the Icelandic Rise, considering both length and depth, but has an axial rift (rather than a high) nearly its entire length. Uniquely along the Southwest Indian Ridge systematic sampling allows direct examination of crustal architecture over its full length. Here we show that, unlike the Icelandic Rise, peridotites are extensively exposed high on the rise, revealing that the crust is generally thin, and often missing, over a rifted rise. Therefore the Marion Rise must be largely an isostatic response to ancient melting events that created low-density depleted mantle beneath the Southwest Indian Ridge rather than thickened crust or a large thermal anomaly. The origin of this depleted mantle is probably the mantle emplaced into the African asthenosphere during the Karoo and Madagascar flood basalt events.

Huaiyang Zhou & Henry J. B. Dick

doi: 10.1038/nature11842

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Identification of a candidate therapeutic autophagy-inducing peptide p.201

The lysosomal degradation pathway of autophagy has a crucial role in defence against infection, neurodegenerative disorders, cancer and ageing. Accordingly, agents that induce autophagy may have broad therapeutic applications. One approach to developing such agents is to exploit autophagy manipulation strategies used by microbial virulence factors. Here we show that a peptide, Tat–beclin 1—derived from a region of the autophagy protein, beclin 1, which binds human immunodeficiency virus (HIV)-1 Nef—is a potent inducer of autophagy, and interacts with a newly identified negative regulator of autophagy, GAPR-1 (also called GLIPR2). Tat–beclin 1 decreases the accumulation of polyglutamine expansion protein aggregates and the replication of several pathogens (including HIV-1) in vitro, and reduces mortality in mice infected with chikungunya or West Nile virus. Thus, through the characterization of a domain of beclin 1 that interacts with HIV-1 Nef, we have developed an autophagy-inducing peptide that has potential efficacy in the treatment of human diseases.

Sanae Shoji-Kawata, Rhea Sumpter, Matthew Leveno, Grant R. Campbell, Zhongju Zou, Lisa Kinch, Angela D. Wilkins, Qihua Sun, Kathrin Pallauf, Donna MacDuff + et al.

doi: 10.1038/nature11866

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Letters

The structure of the asteroid 4 Vesta as revealed by models of planet-scale collisions p.207

Three-dimensional simulations of the global evolution of asteroid 4 Vesta under two overlapping planet-scale collisions closely reproduce its observed shape; but expected large areas of olivine-rich rocks and pure diogenites are not observed on the surface, possibly implying that the outer ~100 km is composed mainly of a basaltic crust (eucrites) with ultramafic intrusions (diogenites).

M. Jutzi, E. Asphaug, P. Gillet, J.-A. Barrat & W. Benz

doi: 10.1038/nature11892

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Hybrid circuit cavity quantum electrodynamics with a micromechanical resonator p.211

The properties of a quantum bit coupled to both a microwave cavity and a phonon mode in a micromechanical resonator suggest that such systems may allow for storage of quantum information in long-lived phonon states and read-out via microwave photons, with applications in quantum information control.

J.-M. Pirkkalainen, S. U. Cho, Jian Li, G. S. Paraoanu, P. J. Hakonen & M. A. Sillanpää

doi: 10.1038/nature11821

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Simple organic molecules as catalysts for enantioselective synthesis of amines and alcohols p.216

A set of small organic molecules catalyse reactions of unsaturated organoboron reagents with imines and carbonyls to produce amines and alcohols in high enantiomeric purity efficiently, speedily and at low cost through sustainable protocols.

Daniel L. Silverio, Sebastian Torker, Tatiana Pilyugina, Erika M. Vieira, Marc L. Snapper, Fredrik Haeffner & Amir H. Hoveyda

doi: 10.1038/nature11844

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Insolation-induced mid-Brunhes transition in Southern Ocean ventilation and deep-ocean temperature p.222

Model simulations show that in response to insolation changes only, southern westerlies and feedbacks between sea ice, temperature, evaporation and salinity caused vigorous Southern Ocean ventilation and cooler deep ocean during the interglacials before the mid-Brunhes transition, suggesting that this transition may in fact have resulted from a series of individual interglacial responses to various combinations of insolation conditions.

Qiuzhen Yin

doi: 10.1038/nature11790

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Vertebral architecture in the earliest stem tetrapods p.226

X-ray synchrotron microtomography has revealed the three-dimensional vertebral architecture of Ichthyostega, and other crucial and celebrated early tetrapods; a surprising feature is the relationship between the vertebral elements, with the pleurocentra unexpectedly attached to the succeeding intercentrum, suggesting a ‘reverse’ rhachitomous design.

Stephanie E. Pierce, Per E. Ahlberg, John R. Hutchinson, Julia L. Molnar, Sophie Sanchez, Paul Tafforeau & Jennifer A. Clack

doi: 10.1038/nature11825

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Finding the sources of missing heritability in a yeast cross p.234

In a cross between two yeast strains, detected loci are found to explain nearly the entire additive contribution to heritable variation for a number of quantitative traits.

Joshua S. Bloom, Ian M. Ehrenreich, Wesley T. Loo, Thúy-Lan Võ Lite & Leonid Kruglyak

doi: 10.1038/nature11867

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Concurrent activation of striatal direct and indirect pathways during action initiation p.238

In mice performing an operant task, increases in neural activity in direct- and indirect-pathway spiny projection neurons (SPNs) are associated with action initiation but not with inactivity, and concurrent activation of SPNs from both pathways in one hemisphere precedes the initiation of contraversive movements.

Guohong Cui, Sang Beom Jun, Xin Jin, Michael D. Pham, Steven S. Vogel, David M. Lovinger & Rui M. Costa

doi: 10.1038/nature11846

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A direct and melanopsin-dependent fetal light response regulates mouse eye development p.243

During retinal vascular development there is simultaneous regression of the hyaloid vasculature and formation of the retinal vasculature; here it is demonstrated that regression of developing vasculature is light dependent and acts via the photoreceptor melanopsin.

Sujata Rao, Christina Chun, Jieqing Fan, J. Matthew Kofron, Michael B. Yang, Rashmi S. Hegde, Napoleone Ferrara, David R. Copenhagen & Richard A. Lang

doi: 10.1038/nature11823

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In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration p.247

A mouse model of liver damage has identified a population of Lrg5+ liver stem cells that can generate hepatoctyes and bile ducts in vivo.

Meritxell Huch, Craig Dorrell, Sylvia F. Boj, Johan H. van Es, Vivian S. W. Li, Marc van de Wetering, Toshiro Sato, Karien Hamer, Nobuo Sasaki, Milton J. Finegold + et al.

doi: 10.1038/nature11826

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Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance p.251

BRAF inhibitors such as vemurafenib have shown promising effects in patients with BRAF-mutant melanomas, but the tumours generally develop resistance; vemurafenib-resistant melanomas are now shown to be drug dependent, and an intermittent dosing schedule can help prevent drug resistance.

Meghna Das Thakur, Fernando Salangsang, Allison S. Landman, William R. Sellers, Nancy K. Pryer, Mitchell P. Levesque, Reinhard Dummer, Martin McMahon & Darrin D. Stuart

doi: 10.1038/nature11814

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A T-bet gradient controls the fate and function of CCR6RORγt+ innate lymphoid cells p.261

The graded expression of the transcription factor T-bet in CCR6−RORγt+ innate lymphoid cells is found to be involved in the control of interferon-γ expression, a cytokine that is required to protect the epithelial barrier against Salmonella infections.

Christoph S. N. Klose, Elina A. Kiss, Vera Schwierzeck, Karolina Ebert, Thomas Hoyler, Yannick d’Hargues, Nathalie Göppert, Andrew L. Croxford, Ari Waisman, Yakup Tanriver + et al.

doi: 10.1038/nature11813

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A complete mass-spectrometric map of the yeast proteome applied to quantitative trait analysis p.266

High-throughput peptide synthesis and mass spectrometry are used to generate a near-complete reference map of the Saccharomyces cerevisiae proteome; two versions of the map (supporting discovery- and hypothesis-driven proteomics) are then applied to a protein-based quantitative trait locus analysis.

Paola Picotti, Mathieu Clément-Ziza, Henry Lam, David S. Campbell, Alexander Schmidt, Eric W. Deutsch, Hannes Röst, Zhi Sun, Oliver Rinner, Lukas Reiter + et al.

doi: 10.1038/nature11835

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