Volume 579 Number 7800

Editorials

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A safe fix for alcohol-derived DNA damage p.499

A by-product of alcohol metabolism can damage the genome by crosslinking opposing DNA strands. The discovery of a safe mechanism that reverses such damage might open up avenues of research for drug discovery.

doi: 10.1038/d41586-020-00462-1

Chromatin modified in a molecular reaction chamber p.503

Chromatin, the complex of DNA and protein in cell nuclei, can be modified by ubiquitin molecules. It emerges that this modification occurs in a molecular reaction chamber formed from an enzyme and a scaffold protein.

doi: 10.1038/d41586-020-00638-9

Forty years of ice-core records of CO2 p.505

In 1980, a method was found to determine the amount of carbon dioxide in ancient air trapped in polar ice — providing direct evidence that CO2 is coupled to climate, and affects global temperatures in the past, present and future.

doi: 10.1038/d41586-020-00809-8

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