Encourage whistle-blowing: how universities can help to resolve research’s mental-health crisis p.651

Low pay, job insecurity, bullying and harassment all contribute to academic researchers reporting above-average levels of anxiety and depression. Institutions can improve working environments by looking at best practice elsewhere.

doi: 10.1038/d41586-023-01703-9

Boost African research in exchange for debt relief p.652

Research will satisfy Africa’s demand for energy — but only if the continent is allowed to invest more in its science and innovation.

doi: 10.1038/d41586-023-01704-8

The world’s top chemical-weapons detectives just opened a brand-new lab p.657

The state-of-the-art centre will help to enforce a near-universal ban on certain chemicals and train analysts from around the world.

doi: 10.1038/d41586-023-01622-9

Carbon capture key to Biden’s new power-plant rule: is the tech ready? p.658

Regulation aims to reduce facilities’ emissions of climate-altering gases — a goal that could require carbon burial.

doi: 10.1038/d41586-023-01595-9

How one man’s rare Alzheimer’s mutation delayed the onset of disease p.660

Genetic resilience found in a person predisposed to early-onset dementia could potentially lead to new treatments.

doi: 10.1038/d41586-023-01610-z

Why is COVID life-threatening for some people? Genetics study offers clues p.661

Immune genes could play a part in the risk of needing intensive care when infected with SARS-CoV-2.

doi: 10.1038/d41586-023-01655-0

‘The disease will be neglected’: scientists react to the WHO ending mpox emergency p.662

Researchers worry that certain regions, including Africa, will suffer if global attention moves away from the outbreak.

doi: 10.1038/d41586-023-01581-1

Hammerhead sharks are first fish found to ‘hold their breath’ p.663

It pays to be an warm hunter in the cold ocean depths, so the animals shut down oxygen intake to conserve heat.

doi: 10.1038/d41586-023-01569-x

China’s mysterious spaceplane returns to Earth — what we know p.664

doi: 10.1038/d41586-023-01639-0

A mental-health crisis is gripping science — toxic research culture is to blame p.666

doi: 10.1038/d41586-023-01708-4

Phosphate-storing organelle discovered in fruit flies p.677

Inorganic phosphate is an essential mineral for cellular metabolism and signalling. It emerges that a fruit-fly organelle can store this chemical in the form of phospholipids, releasing it in times of need.

doi: 10.1038/d41586-023-01410-5

Photon lights a path towards a nuclear clock p.678

A long-sought photon that is emitted by the nucleus of a thorium isotope has now been observed. The feat is a key step in efforts to build a nuclear clock, a device that is precise enough to probe the Universe’s best-kept secrets.

doi: 10.1038/d41586-023-01631-8

A clue to the catalytic activation of splicing p.680

The processing of messenger RNA during splicing requires the activity of a complex of RNAs and proteins termed the spliceosome. Structural data shed light on previously mysterious aspects of splicing in humans.

doi: 10.1038/d41586-023-01528-6

Cocktails of tags enhance resolution of microscopy technique p.681

A limit on the resolution of optical-microscopy techniques has been broken by using a mixture of tags to label copies of target molecules in a sample, opening the way to better views of molecular organization in cells.

doi: 10.1038/d41586-023-01632-7

A step closer to making the mother of stem cells p.683

In the earliest stages of mammalian development, individual cells possess the unrestricted potential to form a new organism. Researchers are closing in on the goal of growing these cells in the laboratory.

doi: 10.1038/d41586-022-01932-4

Molecular basis for muscle loss that causes cachexia p.684

Muscle loss during chronic disease is a life-threatening condition for which there is no effective treatment. The identification of an underlying molecular mechanism might offer new therapeutic targets.

doi: 10.1038/d41586-023-01527-7

Lead immobilization for environmentally sustainable perovskite solar cells p.687

doi: 10.1038/s41586-023-05938-4

Atmospheric molecular blobs shape up circumstellar envelopes of AGB stars p.696

doi: 10.1038/s41586-023-05917-9

A temperate Earth-sized planet with tidal heating transiting an M6 star p.701

doi: 10.1038/s41586-023-05934-8

Observation of the radiative decay of the ²²⁹Th nuclear clock isomer p.706

doi: 10.1038/s41586-023-05894-z

Ångström-resolution fluorescence microscopy p.711

doi: 10.1038/s41586-023-05925-9

Flexible solar cells based on foldable silicon wafers with blunted edges p.717

doi: 10.1038/s41586-023-05921-z

Constrained C₂ adsorbate orientation enables CO-to-acetate electroreduction p.724

doi: 10.1038/s41586-023-05918-8

Catalytic disconnection of C–O bonds in epoxy resins and composites p.730

doi: 10.1038/s41586-023-05944-6

Increased heat risk in wet climate induced by urban humid heat p.738

doi: 10.1038/s41586-023-05911-1

The lunar solid inner core and the mantle overturn p.743

doi: 10.1038/s41586-023-05935-7

De novo evolution of macroscopic multicellularity p.747

doi: 10.1038/s41586-023-06052-1

A weakly structured stem for human origins in Africa p.755

doi: 10.1038/s41586-023-06055-y

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19 p.764

doi: 10.1038/s41586-023-06034-3

Cortico-cortical feedback engages active dendrites in visual cortex p.769

doi: 10.1038/s41586-023-06007-6

Multisensory learning binds neurons into a cross-modal memory engram p.777

doi: 10.1038/s41586-023-06013-8

A pan-grass transcriptome reveals patterns of cellular divergence in crops p.785

doi: 10.1038/s41586-023-06053-0

Induction of mouse totipotent stem cells by a defined chemical cocktail p.792

doi: 10.1038/s41586-022-04967-9

A phosphate-sensing organelle regulates phosphate and tissue homeostasis p.798

doi: 10.1038/s41586-023-06039-y

Microbial peptides activate tumour-infiltrating lymphocytes in glioblastoma p.807

doi: 10.1038/s41586-023-06081-w

Lysine catabolism reprograms tumour immunity through histone crotonylation p.818

doi: 10.1038/s41586-023-06061-0

EDA2R–NIK signalling promotes muscle atrophy linked to cancer cachexia p.827

doi: 10.1038/s41586-023-06047-y

RNA conformational propensities determine cellular activity p.835

doi: 10.1038/s41586-023-06080-x

Structural basis of catalytic activation in human splicing p.842

doi: 10.1038/s41586-023-06049-w