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Liver cancer genetics

Nature Genetics

2011년4월18일

The genome of a chronic hepatitis C (CHC) tumor that tested positive for hepatitis C virus (HCV), as well as a genetic risk locus for HCV-induced HCC, are reported in two independent studies in this week’s Nature Genetics.

More than 170 million people in the world are infected with hepatitis C virus. HCV infection leads to chronic hepatitis C, and consequently liver cirrhosis and hepatocellular carcinoma (HCC).

Tatsuhiro Shibata and colleagues sequenced a primary HCV-positive HCC tumor and matched normal cells from a Japanese male. They identified thousands of tumor-specific mutations. Koichi Matsuda and colleagues performed a genome-wide analysis of 1394 individuals of Japanese ancestry with HCV-induced HCC. The authors identified a locus on chromosome 6p21 that is strongly associated with HCV-induced HCC.

doi: 10.1038/ng.804

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