Biotechnology: Moulding tissues
Nature Communications
2013년5월15일
A simple technique for the arrangement of multiple types of cells into three-dimensional (3D), tissue-like structures is reported in Nature Communications this week. The method, which employs hydrogel moulds, does not require sophisticated laboratory equipment and works even with ‘fragile’ cells, such as stem cells.
Artificially engineered tissues may be useful for regenerative therapies but their 3D architecture is difficult to control, yet crucial for maintaining tissue function. Sangeeta Bhatia and her team grow cells on a patterned surface, which they overlay with a hydrogel. The gel is then removed, exposing a relief that precisely mimics the structural features of the first cell population. A second cell layer, grown on the relief, can then be combined with the first one, yielding a 3D hydrogel that contains multiple micropatterned cellular compartments. The team use this technique, termed “Intaglio-Void/Embed-Relief Topographic (InVERT) molding”, to investigate how the function of stem-cell-derived liver cells is affected by the proximity of surrounding cells. They further show that these tissues can be transplanted and maintain basic functions in mice for several weeks.
doi: 10.1038/ncomms2853
리서치 하이라이트
-
6월30일
Microbiology: Transmission of gastrointestinal viruses in salivaNature
-
6월29일
COVID-19: Assessing instances of long COVID in UK health dataNature Communications
-
6월24일
Sport science: New wearable sensor to measure neck strain may detect potential concussionScientific Reports
-
6월23일
Scientific community: Women credited less than men in scientific paper authorshipNature
-
6월17일
Health technology: New cost-effective smartphone test for middle ear functionCommunications Medicine
-
6월16일
Cancer: Signatures of structural genomic variation in cancerNature