Host control of HIV infection
Nature Communications
2012년3월7일
Host factors seem to play a role in controlling the level of HIV-1 infection in some patients, according to research published in Nature Communications this week. The work describes that two patients, one with very low and another with undetectable levels of the virus, do not have defects in its replication. The researchers suggest this is not because of defects in the virus but factors in the patients themselves that control the circulating amounts of HIV-1. HIV-1 patients that maintain very low levels of virus are known as viremic controllers, other infected patients in whom the virus is undetectable are referred to as elite suppressors. How these two sets of patients maintain low levels of virus is unknown but has been suggested to occur due to a defective virus. Joel Blankson and colleagues studied an elite suppressor patient and a viremic controller patient and demonstrated that the virus found in these patients can multiply in cells in culture, discounting the theory that in these patients the virus was defective in replication. The two patients did not carry genetic variation in the CCR5 gene that is known to slow the progression of HIV disease. These findings suggest that unknown factors in the patients control the levels of virus.
doi: 10.1038/ncomms1697
리서치 하이라이트
-
6월24일
Sport science: New wearable sensor to measure neck strain may detect potential concussionScientific Reports
-
6월23일
Scientific community: Women credited less than men in scientific paper authorshipNature
-
6월17일
Health technology: New cost-effective smartphone test for middle ear functionCommunications Medicine
-
6월16일
An exercise-inducible molecule that suppresses appetiteNature
-
6월16일
Cancer: Signatures of structural genomic variation in cancerNature
-
6월10일
Animals: Genetic clues to how dogs became man’s best friendsScientific Reports