Coming between a virus and its host
Nature Chemical Biology
2010년5월17일
Newly designed small molecules can inhibit HIV replication by blocking a viral-host interaction, reports a study published online this week in Nature Chemical Biology.
Interaction between the HIV-1 enzyme, integrase, and the cellular cofactor LEDGF/p75 plays a crucial role in viral integration. Zeger Debyser and colleagues design small molecules which block this interaction and inhibit HIV replication, even with HIV strains that are resistant to clinically used integrase inhibitors.
This work demonstrates a novel mechanism for inhibiting HIV integrase, and also illustrates the feasibility for the design of small molecules that inhibit protein-protein interaction between a viral protein and a cellular host factor.
doi: 10.1038/nchembio.370
리서치 하이라이트
-
2월18일
Nature Energy Focus issue: How extreme weather events disrupt energy systemsNature Energy
-
1월28일
Materials science: Increased nuclear waste storage corrosion at material interfacesNature Materials
-
1월9일
Ecology: Reassessing impacts of ocean acidification on fish behaviourNature
-
12월20일
Marine biology: Acidified oceans may corrode shark scalesScientific Reports
-
12월19일
Anthropology: The final stand of Homo erectusNature
-
12월17일
Energy: Health and financial impacts of time-of-use energy rates raise equity concernsNature Energy
